The place of chondroitin sulfate and glucosamine sulfate in osteoarthritis pain therapy: a practical view from evidence-based medicine

Наумов, А. В.; Ховасова, Н. О.; Мороз, В. И.; Ткачева, О. Н.

doi:10.17116/jnevro2019119091112

Cited by 5 publications

(2 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to research reports, by the end of 2020, OA affected 7% of the world’s population, more than half a billion people, with women particularly affected [ 1 ]. At present, the commonly used prevention and treatment methods for OA are mainly the application of non-steroidal anti-inflammatory drugs (NSAIDs), or cartilaginous nutrition and protective drugs, such as glucosamine [ 2 , 3 ]. However, long-term use of NSAIDs causes a variety of side effects affecting the gastrointestinal, renal and cardiovascular systems [ 4 ], and these treatments are limited to symptom control and remission progression, resulting in uncertain treatment outcomes in some patients with OA [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Lin

Chen

Guo

et al. 2022

Aging

View full text Add to dashboard Cite

Osteopontin (OPN) has been proved to be closely related to the pathogenesis of osteoarthritis (OA), but the role of OPN in the pathogenesis of OA has not been fully clarified. Current studies on OPN in OA mostly focus on articular cartilage, synovial membrane and articular fluid, while ignoring its role in OA subchondral bone turnover and remodeling. In this study, we used a destabilization OA mouse model to investigate the role of OPN in OA subchondral bone changes. Our results indicate that increased expression of OPN accelerates the turnover and remodeling of OA subchondral bone, promotes the formation of h-type vessels in subchondral bone, and mediates articular cartilage degeneration induced by subchondral bone metabolism. In addition, our results confirmed that inhibition of PI3K/AKT signaling pathway inhibits OPN-mediated OA subchondral bone remodeling and cartilage degeneration. This study revealed the role and mechanism of OPN in OA subchondral bone, which is of great significance for exploring specific biological indicators for early diagnosis of OA and monitoring disease progression, as well as for developing drugs to regulate the metabolism and turnover of subchondral bone and alleviate the subchondral bone sclerosis of OA.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Lin

Chen

Guo

et al. 2022

Aging

View full text Add to dashboard Cite

show abstract

“…Glucosamine sulfate, prescribed for the treatment of osteoarthritis and IDD, has independent antithrombotic activity, due, in part, to the inactivation of the NF-κB signaling pathways in platelets. Although the antithrombotic effects of glucosamine sulfate are, on average, 1.5-3 times weaker than those of NSAIDs, administration of glucosamine sulfate in combination with NSAIDs may enhance its antithrombotic effect [217].…”

Section: Glucosamine Sulfatementioning

confidence: 98%

Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment

Shnayder

Ashkhotov

Trefilova³

et al. 2023

IJMS

View full text Add to dashboard Cite

Intervertebral disc degeneration (IDD) and associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition. With age, IDD progresses, leading to spondylosis, spondylarthrosis, herniated disc, spinal canal stenosis. One of the leading mechanisms in the development of IDD and chronic back pain is an imbalance between pro-inflammatory and anti-inflammatory cytokines. However, classical therapeutic strategies for correcting cytokine imbalance in IDD do not give the expected response in more than half of the cases. The purpose of this review is to update knowledge about new and promising therapeutic strategies based on the correction of the molecular mechanisms of cytokine imbalance in patients with IDD. This review demonstrates that knowledge of the molecular mechanisms of the imbalance between pro-inflammatory and anti-inflammatory cytokines may be a new key to finding more effective drugs for the treatment of IDD in the setting of acute and chronic inflammation.

show abstract

Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study

Khanna¹,

Das²,

Smina³

et al. 2020

The Journal of Alternative and Complementary Medicine

View full text Add to dashboard Cite

The place of chondroitin sulfate and glucosamine sulfate in osteoarthritis pain therapy: a practical view from evidence-based medicine

Cited by 5 publications

References 31 publications

Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment

Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study

Contact Info

Product

Resources

About