Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Lin, Chuangxin; Chen, Zhong; Guo, Dong; Zhou, Lei; Lin, Sipeng; Li, Changchuan; Li, Shixun; Wang, Xinjia; Lin, Bendan; Ding, Yongsheng

doi:10.18632/aging.203707

Cited by 15 publications

(11 citation statements)

References 48 publications

(52 reference statements)

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“…Recently, studies also show the expression of OPN is greatly increased in both the superficial zone and deep zone of articular cartilage of OA patients ( 9 , 44 ). Animal experiments show that increased expression of OPN accelerates the turnover and remodeling of OA subchondral bone, promotes vessels formation in subchondral bone, mediates articular cartilage degeneration induced by subchondral bone metabolism, and accelerates the progression of OA ( 45 ). Some contradictory findings show OPN has a therapeutic value and mechanism in OA treatment.…”

Section: The Structure and Function Of Opnmentioning

confidence: 99%

“…OPN also mediates subchondral bone remodeling and cartilage degeneration in OA. Animal study shows that higher level of OPN secreted by pre-osteoblasts and osteoblasts in subchondral bone could promote osteoclastogenesis and blood vessels formation in subchondral bone, accelerate the turnover and remodeling of subchondral bone and mediate articular cartilage degeneration induced by subchondral bone metabolism in anterior cruciate ligament transection and destabilization of the medial meniscus (ACLT + DMM) OA model ( 45 ). Furthermore, OPN is also on behalf of the osteogenic and chondrogenic differentiation progress, abnormal expression of OPN along with Runx2, Sox9, and OCN may induce metabolic disturbance and cartilage damage in OA ( 51 , 73 ).…”

Section: Opn Involves In Cartilage and Bone Metabolism In Oa And Opmentioning

confidence: 99%

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Osteopontin, a bridge links osteoarthritis and osteoporosis

Bai

Li²,

Zhang³

2022

Front. Endocrinol.

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Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases.

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Section: The Structure and Function Of Opnmentioning

confidence: 99%

Section: Opn Involves In Cartilage and Bone Metabolism In Oa And Opmentioning

confidence: 99%

Osteopontin, a bridge links osteoarthritis and osteoporosis

Bai

Li²,

Zhang³

2022

Front. Endocrinol.

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“…A previous study has shown that the expression of osteopontin (OPN) is increased in osteoarthritis, that it accelerates the renewal and remodeling of subchondral bone in osteoarthritis, and that it mediates the degeneration of articular cartilage induced by subchondral bone metabolism ( 68 ). Liu et al ( 69 ) found that circ_0005564 was highly expressed and decreased the mRNA expression of RUNX2 and OPN during the osteogenic differentiation of BMSCs, and that knockdown of circ_0005564 inhibited osteoblast differentiation in BMSCs.…”

Section: Associations Between Circrnas and Bmscsmentioning

confidence: 99%

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)

Wang

Zhang

et al. 2022

Mol Med Rep

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Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are therefore defined as pluripotent cells. BMSCs have become extremely important seed cells in gene therapy, tissue engineering, cell replacement therapy and regenerative medicine due to their potential in multilineage differentiation, self-renewal, immune regulation and other fields. Circular RNAs (circRNAs) are a class of non-coding RNAs that are widely present in eukaryotic cells. Unlike standard linear RNAs, circRNAs form covalently closed continuous loops with no 5′ or 3′ polarity. circRNAs are abundantly expressed in cells and tissues, and are highly conserved and relatively stable during evolution. Numerous studies have shown that circRNAs play an important role in the osteogenic differentiation of BMSCs. Further studies on the role of circRNAs in the osteogenic differentiation of BMSCs can provide a new theoretical and experimental basis for bone tissue engineering and clinical treatment.

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“…On the one hand, the activation of PI3K-AKT pathway can increase the expression of many signaling molecules associated with bone formation including ALP and BMP-2, which in turn promote the proliferation and differentiation of osteoblasts. On the other hand, its downstream signaling molecules such as RANK and c-FMS can take part in the process of osteoclast-mediated bone resorption (44)(45)(46)(47)(48)(49).…”

Section: Discussionmentioning

confidence: 99%

Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation

Zhang

et al. 2022

Front. Endocrinol.

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BackgroundGlucocorticoid-induced osteoporosis (GIOP) is a common form of secondary osteoporosis caused by the protracted or a large dosage of glucocorticoids (GCs). Total flavonoids of Drynariae rhizoma (TFDR) have been widely used in treating postmenopausal osteoporosis (POP). However, their therapeutic effects and potential mechanism against GIOP have not been fully elucidated.MethodsUltra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-ESIQ-TOF-MS) experiments were performed for qualitative analysis. We performed hematoxylin-eosin (HE) staining and microcomputed tomography (micro-CT) analysis to detect the changes in bone microstructure. The changes in biochemical parameters in the serum samples were determined by performing an enzyme-linked immunosorbent assay (ELISA). The prediction results of network pharmacology were verified via quantitative real-time polymerase chain reaction (qRT-PCR) to elucidate the potential mechanism of TFDR against GIOP.ResultsA total of 191 ingredients were identified in vitro and 48 ingredients in vivo. In the in-vivo experiment, the levels of the serum total cholesterol (TC), the serum triglyceride (TG), Leptin (LEP), osteocalcin (OC), osteoprotegerin (OPG), bone morphogenetic protein-2 (BMP-2), propeptide of type I procollagen (PINP), tartrate-resistant acid phosphatase (TRACP) and type-I collagen carboxy-terminal peptide (CTX-1) in the TFDR group significantly changed compared with those in the GIOP group. Moreover, the TFDR group showed an improvement in bone mineral density and bone microstructure. Based on the results of network pharmacology analysis, 67 core targets were selected to construct the network and perform PPI analysis as well as biological enrichment analysis. Five of the targets with high “degree value” had differential gene expression between groups using qRT-PCR.ConclusionTFDR, which may play a crucial role between adipose metabolism and bone metabolism, may be a novel remedy for the prevention and clinical treatment of GIOP.

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Increased expression of osteopontin in subchondral bone promotes bone turnover and remodeling, and accelerates the progression of OA in a mouse model

Cited by 15 publications

References 48 publications

Osteopontin, a bridge links osteoarthritis and osteoporosis

Osteopontin, a bridge links osteoarthritis and osteoporosis

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells (Review)

Total Flavonoids of Drynariae Rhizoma Improve Glucocorticoid-Induced Osteoporosis of Rats: UHPLC-MS-Based Qualitative Analysis, Network Pharmacology Strategy and Pharmacodynamic Validation

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