The physiopathologic role of oxidative stress in skeletal muscle

Scicchitano, Bianca Maria; Pelosi, Laura; Sica, Gigliola; Musarò, Antonio

doi:10.1016/j.mad.2017.08.009

Cited by 94 publications

(69 citation statements)

References 121 publications

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“…The high metabolic rate observed in IGF‐1Ea muscle was correlated with high ROS production. These mice, however, were able to minimize oxidative damage in senescent muscle up‐regulating, through PGC1‐α activation, NRF‐2 protein, the master regulator of antioxidant defense (Scicchitano, Pelosi, Sica, & Musarò, ) and Sirt‐1, a factor involved in growth regulation, stress response, endocrine signaling, and extended lifespan. In aged IGF1‐Ea mice, the increased levels of markers involved in the fusion and fission of mitochondria could further contribute to the control of mitochondrial quality and functionality.…”

Section: Discussionmentioning

confidence: 99%

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

et al. 2019

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The decline in skeletal muscle mass and strength occurring in aging, referred as sarcopenia, is the result of many factors including an imbalance between protein synthesis and degradation, changes in metabolic/hormonal status, and in circulating levels of inflammatory mediators. Thus, factors that increase muscle mass and promote anabolic pathways might be of therapeutic benefit to counteract sarcopenia. Among these, the insulin‐like growth factor‐1 (IGF‐1) has been implicated in many anabolic pathways in skeletal muscle. IGF‐1 exists in different isoforms that might exert different role in skeletal muscle. Here we study the effects of two full propeptides IGF‐1Ea and IGF‐1Eb in skeletal muscle, with the aim to define whether and through which mechanisms their overexpression impacts muscle aging. We report that only IGF‐1Ea expression promotes a pronounced hypertrophic phenotype in young mice, which is maintained in aged mice. Nevertheless, examination of aged transgenic mice revealed that the local expression of either IGF‐1Ea or IGF‐1Eb transgenes was protective against age‐related loss of muscle mass and force. At molecular level, both isoforms activate the autophagy/lysosome system, normally altered during aging, and increase PGC1‐α expression, modulating mitochondrial function, ROS detoxification, and the basal inflammatory state occurring at old age. Moreover, morphological integrity of neuromuscular junctions was maintained and preserved in both MLC/IGF‐1Ea and MLC/IGF‐1Eb mice during aging. These data suggest that IGF‐1 is a promising therapeutic agent in staving off advancing muscle weakness.

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Section: Discussionmentioning

confidence: 99%

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

et al. 2019

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“…Therefore, we can suggest that lean body mass could be implicated in infertility since it plays an important role in the control of systemic energy metabolism and insulin sensitivity [66]—both of which interfere with fertility [67]. Moreover, low muscle mass can be associated with oxidative stress [68]. Bone mineral content has also been associated with decreased sex hormone levels [69].…”

Section: Discussionmentioning

confidence: 99%

Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women

Foucaut

Faure

Julia

et al. 2019

Preprint

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23 24 ^A lifert Collaborative Group: Isabelle Aknin: Unité fonctionnelle de biologie de la reproduction, histologie -25 embryologie -cytogénétique, hôpital Nord, Saint-Étienne, France ; Isabelle Cedrin-Durnerin: Service de 26 Médecine de la Reproduction, Hôpital Jean Verdier, APHP, 37 38 Preferred citation: Foucaut A-M, Faure C, Julia C, Czernichow S, Levy R, Dupont C, and the ALIFERT 39 collaborative group. Sedentary behavior, physical inactivity and body composition in relation to idiopathic 40 infertility among men and women.Abstract 42 Background: Physical activity and sedentary behavior has inconsistent effects on fertility. High 43 body mass index is associated with infertility but to our knowledge, very few studies have 44 explored body composition in association to fertility. 45 Objective: To assess the association between physical inactivity, sedentary behavior, body 46 composition and idiopathic infertility in French men and women. 47 Design: We conducted a case-control multicentric observational study. 159 infertile (79 men and 80 48 women) and 143 fertile (72 men and 71 women) were recorded in four fertility centers. 49 Main Outcome Measures: Participants completed self-administered questionnaires on 50 sociodemographic and lifestyle characteristics, dietary intake, physical activity and sedentary 51 behavior. Anthropometrics were measured, and bioelectrical impedance analysis was used to 52 estimate body composition. Multivariable logistic regression was used to analyze the association of 53 fertility with PA level and sedentary behavior. 54 Results: In men, being physically inactive (Odd ratio [OR] 2.20; 95% confidence interval [CI], 1.06, 55 4.58) and having fat mass greater than the reference values for their age (OR 2.83; 95%CI, 1.31, 6.10) 56 were positively associated with infertility. Sedentary behavior and fat-free mass were not related to 57 infertility in men. In women, sedentary behavior (OR 3.61; 95%CI, 1.58, 8.24), high body fat (OR 3.16; 58 95%CI, 1.36, 7.37) and low fat-free mass (OR 2.65; 95%CI, 1.10, 6.37) were associated with infertility. 59 PA level was not associated with fertility in women. 60 Conclusions: This study suggests that sedentary behavior and physical inactivity would represent two 61 independent risk factors associated with fertility. The various elements that make up physical activity 62 (frequency, intensity, time, and type of exercise) and the interrupting time spent sitting should be 63 considered. Body composition variation should be explored further in relation to the biological 64 pathways involved in idiopathic infertility. Moreover, the improvement of lifestyle factors should be 65 considered in infertility treatment. 66 Key words: infertility, physical activity, sedentary behavior, lifestyle, body composition. 80 relationship between PA and semen quality [11,12]. In women, moderate PA increased fecundity 81 parameters and live birth rates, regardless of body mass index (BMI) [13,14]-even during assisted 82 reproductive treatment [15-17]. However, vigorous ac...

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“…The gradual decreases in mass, muscle strength and joint flexibility associated with ageing interfere with the physical and functional capacity of the organism. 36 Individuals with Parkinson's disease have functional abnormalities that compromise skeletal striated musculature. 37 Common clinical signs related to ageing include sarcopenia, which is characterised by a loss of muscle mass and, in Parkinson's disease, muscle atrophy associated with stiffness.…”

Section: The Increase In Muscle Activity During Maximal Protrusion Inmentioning

confidence: 99%

Effects of Parkinson's disease on molar bite force, electromyographic activity and muscle thickness of the masseter, temporal and sternocleidomastoid muscles: A case‐control study

Verri

Silva

Fioco

et al. 2019

J of Oral Rehabilitation

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Background Parkinson's disease is a neurological disorder that promotes motor changes in the body. Objective The aim of this study was to investigate the impairment of the stomatognathic function regarding molar bite force, electromyographic activity and thickness of the craniocervical muscles in patients with Parkinson's disease in comparison with those in asymptomatic controls. Methods Twenty‐four subjects were divided into two groups, a Parkinson's disease group (n = 12) and a control group (n = 12). The subjects were evaluated on the basis of molar bite force, electromyographic activity (rest, right and left laterality, protrusion, maximum voluntary contraction) and thickness (rest and maximum voluntary contraction) of the right and left temporal (anterior portion), masseter and sternocleidomastoid muscles. The results were submitted to a multivariate analysis of variance (MANOVA) to compare the means of the two independent groups, considering diagnosis of Parkinson's disease and craniocervical muscles as independent variables. For the post hoc comparisons, Bonferroni correction was used (P < 0.05). Results Parkinson's disease group presented lower mean values both sides for maximal molar bite force, significant increases in the electromyographic activities during mandibular tasks, lower mean thickness values of the masseter and sternocleidomastoid muscles, and higher mean thickness values of the temporalis muscles (anterior portion). Conclusion The results suggest that patients with Parkinson's disease may present functional changes of the stomatognathic system, related to bite force, electromyographic activity and thickness of the craniocervical muscles. The greater temporal muscle thickness in Parkinson's disease patients may compromise their daily life activities, especially with respect to chewing and nutrition.

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The physiopathologic role of oxidative stress in skeletal muscle

Cited by 94 publications

References 121 publications

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

Sedentary behavior, physical inactivity and body composition in relation to idiopathic infertility among men and women

Effects of Parkinson's disease on molar bite force, electromyographic activity and muscle thickness of the masseter, temporal and sternocleidomastoid muscles: A case‐control study

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