The Physiology of Insulin Release

Lacy, Paul E.

doi:10.1007/978-1-4684-2325-9_8

Cited by 8 publications

(2 citation statements)

References 70 publications

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“…There is general agreement that glucose has a direct effect on the B cell [13] either through being metabolised and forming specific metabolites or co-factors which initiate insulin release [14] or by activating glucoreceptors in the B-cell membrane [15]. Glucagon antiserum would not be expected to have any effect on such a direct B-cell action.…”

Section: Discussionmentioning

confidence: 99%

Divergent effect of glucagon antibodies on arginine and glucose-stimulated insulin secretion in the rat

Tan

Atabani

1985

Diabetologia

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The effects of glucose and arginine on insulin secretion in the presence of glucagon antibodies were investigated in rats in vivo. In contrast to controls, animals given glucagon antibodies showed an inhibition of arginine-stimulated (p less than 0.001), but not glucose-stimulated, insulin secretion. That these effects were not due to incomplete neutralisation of endogenous glucagon is evidenced by the presence of large antibody excess throughout the duration of the experiments. Both the glucagonotropic effect of arginine (319 +/- 60 ng/l, p less than 0.01) and the insulinotropic effect of exogenous glucagon (8.3 +/- 0.8 microgram/l, p less than 0.001) were demonstrable under our experimental conditions in the absence of exogenous glucagon antibodies. These observations suggest that different mechanisms are involved in the stimulation of insulin release by arginine and by glucose, and that glucagon may play an important physiological role in the mediation and regulation of insulin secretion by secretogogues, such as arginine.

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Section: Discussionmentioning

confidence: 99%

Divergent effect of glucagon antibodies on arginine and glucose-stimulated insulin secretion in the rat

Tan

Atabani

1985

Diabetologia

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“…These symptoms can be experimentally induced by alloxan or streptozotocin and can be prevented with injections of exogenous insulin. Insulin is released from the pancreas in response to glucose, free fatty acids, and some amino acids such as leucine (Lacy, 1977).…”

Section: Pancreatectomy In Alligator Mississippiensis (Classmentioning

confidence: 99%

A novel insulin from the bullfrog: its structure and function in protein secretion by hepatocytes

Hulsebus

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The influence of pancreatic hormones and diabetogenic procedures on erythropoietin production

Naughton

Liu

et al. 1982

Journal of Surgical Oncology

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The influence of the pancreas on renal and extrarenal erythropoietin (Ep) production and on the elaboration of the hepatic erythropoietic factor (HEF) was studied in these experiments. Insulin was found to elevate Ep levels in the anephric hypoxic rat when compared to controls, whereas glucagon treatment augmented the hepatic Ep response to hypoxia in the subtotally hepatectomized (hepx) animal while lowering it in the renal intact rat. Production of experimental diabetes either through chemical induction by alloxan or following pancreatectomy diminished the Ep response in all groups tested. Treatment with antiglucagon caused an elevation in the Ep response to hypoxia in the intact rat but lowered Ep levels in the hepx animal. In addition, glucagon and a synthetic hepatotrophic agent (L-histidyl L-lysine acetate) stimulated HEF production in the hepx rat, although none of the agents tested were capable of enhancing HEF levels in the intact rat.

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The Physiology of Insulin Release

Cited by 8 publications

References 70 publications

Divergent effect of glucagon antibodies on arginine and glucose-stimulated insulin secretion in the rat

Divergent effect of glucagon antibodies on arginine and glucose-stimulated insulin secretion in the rat

A novel insulin from the bullfrog: its structure and function in protein secretion by hepatocytes

The influence of pancreatic hormones and diabetogenic procedures on erythropoietin production

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