The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review

Tack, Christopher; Shorthouse, Faye; Kass, Lindsy

doi:10.1123/ijsnem.2017-0267

Cited by 12 publications

(8 citation statements)

References 89 publications

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“…Human muscle, tendinous tissue, and their corresponding collagen‐rich extracellular matrix (ECM) produce and transmit muscular force to the skeleton and are sensitive to environmental factors such as mechanical 1 , 2 and nutritional 3 , 4 stimuli. Consequently, resistance training (RT), or a combination of RT and nutrition, facilitates remodeling these tissues to enhance physical function and resilience, 5 , 6 injury prevention/rehabilitation, 7 , 8 or healthy aging.…”

Section: Introductionmentioning

confidence: 99%

The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training

et al. 2022

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Aim: Bioactive collagen peptides (CP) have been suggested to augment the functional, structural (size and architecture), and contractile adaptations of skeletal muscle to resistance training (RT), but with limited evidence. This study aimed to determine if CP vs. placebo (PLA) supplementation enhanced the functional and underpinning structural, and contractile adaptations after 15 weeks of lower body RT. Methods: Young healthy males were randomized to consume either 15 g of CP (n = 19) or PLA (n = 20) once every day during a standardized program of progressive knee extensor, knee flexor, and hip extensor RT 3 times/wk. Measurements pre-and post-RT included: knee extensor and flexor isometric strength; quadriceps, hamstrings, and gluteus maximus volume with MRI; evoked twitch contractions, 1RM lifting strength, and architecture (with ultrasound) of the quadriceps.Results: Percentage changes in maximum strength (isometric or 1RM) did not differ between-groups (0.684 ≤ p ≤ 0.929). Increases in muscle volume were greater (quadriceps 15.2% vs. 10.3%; vastus medialis (VM) 15.6% vs. 9.7%; total muscle volume 15.7% vs. 11.4%; [all] p ≤ 0.032) or tended to be greater (hamstring 16.5% vs. 12.8%; gluteus maximus 16.6% vs. 12.9%; 0.089 ≤ p ≤ 0.091) for CP vs.PLA. There were also greater increases in twitch peak torque (22.3% vs. 12.3%; p = 0.038) and angle of pennation of the VM (16.8% vs. 5.8%, p = 0.046), but not other muscles, for CP vs. PLA. Conclusions: CP supplementation produced a cluster of consistent effects indicating greater skeletal muscle remodeling with RT compared to PLA. Notably, CP supplementation amplified the quadriceps and total muscle volume increases induced by RT.

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Section: Introductionmentioning

confidence: 99%

The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training

et al. 2022

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“…This study also demonstrated that lactic acid synthesis inhibitors could promote the recovery of biomechanical properties of injured tendons ( 45 ). In 2017, Tack et al demonstrated the role of direct (synthesis rate modification) and indirect (antioxidant) mechanisms in tendon healing in animal models by studying the effects of amino acids and vitamins, effects of amino acids and vitamins ( 46 ).…”

Section: Treatment Of Tendon Injuriesmentioning

confidence: 99%

Basic Research on Tendon Repair: Strategies, Evaluation, and Development

Yang

Zhou

2021

Front. Med.

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Tendon is a fibro-elastic structure that links muscle and bone. Tendon injury can be divided into two types, chronic and acute. Each type of injury or degeneration can cause substantial pain and the loss of tendon function. The natural healing process of tendon injury is complex. According to the anatomical position of tendon tissue, the clinical results are different. The wound healing process includes three overlapping stages: wound healing, proliferation and tissue remodeling. Besides, the healing tendon also faces a high re-tear rate. Faced with the above difficulties, management of tendon injuries remains a clinical problem and needs to be solved urgently. In recent years, there are many new directions and advances in tendon healing. This review introduces tendon injury and sums up the development of tendon healing in recent years, including gene therapy, stem cell therapy, Platelet-rich plasma (PRP) therapy, growth factor and drug therapy and tissue engineering. Although most of these therapies have not yet developed to mature clinical application stage, with the repeated verification by researchers and continuous optimization of curative effect, that day will not be too far away.

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“…Besides, the SSAD-derived hydrogel also has antioxidant and antibacterial properties, which aid in reducing peritendinous adhesion. [36][37][38][39] Moreover, the pore size of the SSAD-derived hydrogel could be controlled easily by rationally choosing the SSAD powder size. We could take advantage of structure of the smaller pores to resist cell invasion as a barrier Small 2022, 18, 2105255 Figure 1.…”

Section: Introductionmentioning

confidence: 99%

A Natural Hydrogel with Prohealing Properties Enhances Tendon Regeneration

Dang

Chen

Sefat

et al. 2022

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Tendon regeneration and reduction of peritendinous adhesion remain major clinical challenges. This study addresses these challenges by adopting a unique hydrogel derived from the skin secretion of Andrias davidianus (SSAD) and taking advantage of its biological effects, adhesiveness, and controllable microstructures. The SSAD‐derived hydrogel contains many cytokines, which could promote tendon healing. In vitro, leach liquid of SSAD powder could promote tendon stem/progenitor cells migration. In vivo, the SSAD‐derived hydrogel featuring double layers possesses strong adhesiveness and could reconnect ruptured Achilles tendons of Sprague‐Dawley rats without suturing. The intimal SSAD‐derived hydrogel, with a pore size of 241.7 ± 21.0 µm, forms the first layer of the hydrogel to promote tendon healing, and the outer layer SSAD‐derived hydrogel, with a pore size of 3.3 ± 1.4 µm, reducing peritendinous adhesion by serving as a dense barrier. Additionally, the SSAD‐derived hydrogel exhibits antioxidant and antibacterial characteristics, which further contribute to the reduction of peritendinous adhesion. In vivo studies suggest that the SSAD‐derived hydrogel reduces peritendinous adhesion, increases collagen fiber deposition, promotes cell proliferation, and improves the biomechanical properties of the regenerated tendons, indicating better functional restoration. The SSAD‐derived bilayer hydrogel may be a feasible biomaterial for tendon repair in the future.

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The Physiological Mechanisms of Effect of Vitamins and Amino Acids on Tendon and Muscle Healing: A Systematic Review

Cited by 12 publications

References 89 publications

The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training

The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training

Basic Research on Tendon Repair: Strategies, Evaluation, and Development

A Natural Hydrogel with Prohealing Properties Enhances Tendon Regeneration

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