The physiological action of β‐iminazolylethylamine

Dale, H. H.; Laidlaw, P. P.

doi:10.1113/jphysiol.1910.sp001406

Cited by 834 publications

(217 citation statements)

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“…The contractile activity of histamine in the intestinal smooth muscle has long been known (Dale & Laidlaw, 1910) but relatively few studies have been carried out on the effect of histamine on large intestinal smooth muscle (Parsons, 1982). The present results show that histamine produces dose-dependent contractions in guinea-pig isolated longitudinal colon strips.…”

Section: Discussionsupporting

confidence: 58%

Pharmacological investigation into the effects of histamine and histamine analogues on guinea‐pig and rat colon in vitro

Aguilar¹,

Morales‐Olivas²,

Rubio³

1986

British J Pharmacology

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1 The effects ofhistamine and specific histamine agonists has been examined on isolated longitudinal colon strips of guinea-pig and rat. 2 Histamine and 2-pyridyl-ethylamine but not 4 methylhistamine produced a concentration-related contractile response in the guinea-pig colon. 3 The H,-antagonist clemizole antagonized competitively the effect of histamine but the H2-antagonist ranitidine did not modify the dose-response curve to histamine in the guinea-pig colon. 4 Atropine, hexamethonium, prazosin and propranolol failed to modify the contractile response to histamine. 5 Tone induced with KCI in guinea-pig isolated colon was not modified by histamine agonists even in tissues pretreated with clemizole or ranitidine. 6 Histamine and histamine analogues were without effect on the isolated longitudinal strip of the rat colon. 7 It is concluded that histamine produced dose-dependent contractions ofthe guinea-pig colon due to direct activation of H,-histamine receptors. There is no evidence in favour of the existence of H2-histamine receptors in this preparation. The lack ofeffect of histamine agonists in rat colon strip argues against the existence of histamine receptors in this preparation.

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Section: Discussionsupporting

confidence: 58%

Pharmacological investigation into the effects of histamine and histamine analogues on guinea‐pig and rat colon in vitro

Aguilar¹,

Morales‐Olivas²,

Rubio³

1986

British J Pharmacology

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“…Many fundamental processes, mediators and regulators of airways disease pathogenesis were discovered or demonstrated first in guinea pigs, including the Schultz-Dale (immediate type hypersensitivity) reaction, the actions of histamine, the cysteinyl-leukotrienes and their two receptors, beta adrenoceptor subtypes, thromboxane, vascular endothelial growth factor (VEGF), eotaxin, alveolar macrophage derived neutrophil chemotactic factor(s) (leukotriene B 4 and/or IL-8) and the roles of cAMP and inositol triphosphate in signal transduction [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Receptor pharmacology in guinea pigs more closely matches that of human receptor pharmacology than most other commonly used species [1,20,21] (Table 1, Figs.…”

Section: Introductionmentioning

confidence: 99%

Using guinea pigs in studies relevant to asthma and COPD

Canning

Chou

2008

Pulmonary Pharmacology & Therapeutics

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The guinea pig has been the most commonly used small animal species in preclinical studies related to asthma and COPD. The primary advantages of the guinea pig are the similar potencies and efficacies of agonists and antagonists in human and guinea pig airways and the many similarities in physiological processes, especially airway autonomic control and the response to allergen. The primary disadvantages to using guinea pigs are the lack of transgenic methods, limited numbers of guinea pig strains for comparative studies and a prominent axon reflex that is unlikely to be present in human airways. These attributes and various models developed in guinea pigs are discussed.

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“…(2) Histamine causes increased output of adrenaline and the effect is in part a direct one on the adrenals.…”

Section: Discussionmentioning

confidence: 99%

On the concentration of the blood and the effects of histamine in adrenal insufficiency

Kellaway¹,

Cowell²

1922

The Journal of Physiology

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THE experimental production of acute adrenal insufficiency by removal of both glands is attended, as Gradinescu(5) first showed, by a steady rise in the number of red corpuscles per c.mm. of blood. Donath(3) subsequently observed that the weight of the dry residue of the blood increases after bilateral extirpation. Dale(l) also observed this concentration of the blood after removal of both adrenals and found associated with it a greatly increased susceptibility to histamine.Our investigations have been primarily directed to determining the parts played by defect of cortex and medulla respectively in causing this concentration of the blood and increased susceptibility to histamine. In the course of our work we have noted certain other features of adrenal instifficiency, and investigated the concentration of the blood caused by injecting intravenously small doses of histamine. METHODS.The experiments were made on adult cats1. In order to destroy the medulla, radium emanation, in dose generally varying from *26 to 1.5 mg., was embedded in it. The emanation was enclosed in a sealed glass capillary tube 4 to 6 mm. in length, and just under 1 mm. in diameter. The adrenal was exposed through the flank, slung up by a ligature tied to the divided lumbo-adrenal vein, and a small incision made into one pole. The tube containing the emanation was placed in the end of a glass tube bent nearly to a right angle and just large enough to contain it. The containing tube was thrust into the medulla, and the emanation tube was extruded by a piece of flexible piano wire, prevented from going too far by a glass bead. Since the emanation has a rather rapid rate of decay it was left in the gland, except in a few cases in which larger doses (15 to 21 mg.) were implanted, for four or more hours and removed at a subsequent 1 All survival operations were carried out by Kellaway under ether anesthesia with full aseptic precautions.

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The physiological action of β‐iminazolylethylamine

Cited by 834 publications

References 0 publications

Pharmacological investigation into the effects of histamine and histamine analogues on guinea‐pig and rat colon in vitro

Pharmacological investigation into the effects of histamine and histamine analogues on guinea‐pig and rat colon in vitro

Using guinea pigs in studies relevant to asthma and COPD

On the concentration of the blood and the effects of histamine in adrenal insufficiency

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