2005
DOI: 10.1016/j.ygeno.2005.08.004
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The phylogenetic analysis of tetraspanins projects the evolution of cell–cell interactions from unicellular to multicellular organisms

Abstract: In animals, the tetraspanins are a large superfamily of membrane proteins that play important roles in organizing various cell-cell and matrix-cell interactions and signal pathways based on such interactions. However, their origin and evolution largely remain elusive and most of the family's members are functionally unknown or less known due to difficulties of study, such as functional redundancy. In this study, we rebuilt the family's phylogeny with sequences retrieved from online databases and our cDNA libra… Show more

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Cited by 144 publications
(164 citation statements)
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References 43 publications
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“…Caenorhabditis elegans and at least 25 in the parasite Schistosoma [29]. Although some tetraspanins have been demonstrated to be potential vaccine candidates against different stages of schistosome infection [19][20][21][22], nothing is known about them in another important platyhelminth E. multilocularis.…”
Section: Discussionmentioning
confidence: 99%
“…Caenorhabditis elegans and at least 25 in the parasite Schistosoma [29]. Although some tetraspanins have been demonstrated to be potential vaccine candidates against different stages of schistosome infection [19][20][21][22], nothing is known about them in another important platyhelminth E. multilocularis.…”
Section: Discussionmentioning
confidence: 99%
“…A propidium iodide (PI) and Annexin V-FITC flow cytometry assay (BD Pharmingen) was used to detect the apoptosis rate in the cells after Tspan1 transfection. Briefly, 1x10 6 cells/well were cultured in 6-well plates in the absence of 10% FBS for 48 h. Adherent cells were detached with 0.25% trypsin without EDTA in 1X PBS. Cells were harvested in complete RPMI-1640 medium and centrifuged at 1,000 rpm for 5 min.…”
Section: Ihc Stainingmentioning
confidence: 99%
“…Tetraspanins interact with various transmembrane proteins, establishing a network of large multimolecular complexes that allows specific lateral secondary interactions (5). In animals, the tetraspanins are a large superfamily of membrane proteins that play important roles in organizing various cell-cell and matrix-cell interactions and signal pathways based on such interactions (6,7).…”
Section: Introductionmentioning
confidence: 99%
“…They are highly conserved and can be found in species as disparate as fungi and mammals (39). In humans, CD82 is expressed in many cell types, including lymphocytes (40), granulocytes (41), epithelial cells (42), platelets (43), endothelial cells (44), and fibroblasts (45).…”
Section: Discussionmentioning
confidence: 99%