The Photopathology and Nature of the Blue Light and Near-UV Retinal Lesions Produced by Lasers and Other Optical Sources

HamJr., William T.; Mueller, Harold A.

doi:10.1007/978-1-4613-0745-7_5

Cited by 67 publications

(40 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At P10, the rat pup retina is developmentally comparable to a 12-to 14-week-old human fetal retina [24], None of the quadrants from the P10 exposure group showed any statistically significant differences between experimental and control retinas. At this stage of development, the rat pup's closed eyelids prevent up to 90% of the short-wave length light [25], which is especially damaging [3], from reaching the retina.…”

Section: Discussionmentioning

confidence: 99%

“…There fore, pigmentation of choroid, iris, and pigment epithe lium, especially later in gestation, should help protect the fetal human eye against light damage. Second, using pub lished measurements on the fetal human retina [30,31], neonatal rat eyes, and our own measurements of the neo natal rat eye, we calculated the irradiance (from the same source) falling on the neonatal rat retina to be approxi mately two times that falling on the fetal human retina [3,[32][33][34], Third, we have used a continuous exposure of 1 h, maintaining the endoscope within 4-6 mm from the cor nea, while clinical observations usually involve only indi rect, brief, or intermittent exposure of the eye.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Endoscopic White Light on the Developing Rat Retina

et al. 1997

View full text Add to dashboard Cite

Objective: Our goal was to determine the effect of endoscopic white light on the developing mammalian retina by quantitative histological analysis. Study Design: Albino rats at postnatal days 10 (n = 16) and 16 (n = 20) were exposed to endoscopic white light for 1 h, while an equal number of littermate controls were not exposed, but otherwise treated identically. The thickness of the outer nuclear layer (ONL) and the total retinal thickness were measured light microscopically using a computer-assisted morphometry program. Results: We found no statistically significant decrease in the thickness of the ONL or the total retinal thickness, nor were any significant decreases found in the ONL or the total retinal thickness for male or female groups. Conclusion: Endoscopic white light does not cause damage to the developing rodent neural retina detectable at the light microscopic level.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Endoscopic White Light on the Developing Rat Retina

et al. 1997

View full text Add to dashboard Cite

show abstract

“…This is known as the blue light hazard which has its peak efficacy around 440nm for an eye with a natural lens (24). Retinal damage has been attributed to short exposure to high intensity artificial light sources; there is also evidence that long term exposure to solar radiation may cause similar clinical signs as seen in short exposures which mimic the clinical changes seen in age related macular degeneration (AMD) (20). However, large scale population studies of AMD and sunlight exposure are inconclusive (13,36) and there is no available evidence as to the prevalence of AMD in the professional pilot population (6).…”

Section: Introductionmentioning

confidence: 99%