The pharmacology of ornipressin (POR-8): a local vasoconstrictor used in surgery

Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow

“…Despite decreased regional and microcirculatory blood flow in the kidney, urine output increased. Vasopressin produces vasoconstriction via the V1Rs, whereas osmoregulation, antidiuretic effects, and nitric-oxide-dependent vasodilatation are mediated via the V2 receptors (V2Rs) [ 39 ]. In the present study, we used the vasopressin analogue ornithin-8-vasopressin, which has effects very similar to those of arginine vasopressin but a slightly higher affinity for V1R.…”

Local Anesthesia in Hair Transplantation

“…However, cardiovascular effects have been reported. ST depression was found in a 19‐year‐old who had 0.8 IU of ornipressin injected into peritonsillar tissues 27 . Studies of cardiac effects in guinea pigs found coronary vasoconstriction, leading to decreased coronary blood flow and increased oxygen extraction 28 .…”

“…Studies of cardiac effects in guinea pigs found coronary vasoconstriction, leading to decreased coronary blood flow and increased oxygen extraction 28 . Ornipressin can also cause elevation of blood pressure and affect heart rates 27,29 . Thus ornipressin must be used with caution in patients with hypertension or coronary artery disease.…”