The Pharmacology and Toxicology of Tetrachlorethylene*

Liver Function as Tested by the Lipemic Curve After Intravenous Fat Administration 1

“…Nevertheless, it seems probable to us that such is the case. Lamson and his coworkers (14) showed that when carbon tetrachloride was introduced as we have introduced it, damage was manifest only in the liver, and we are impressed with the work we have quoted above implicating the liver particularly in the disposal of fat. On the whole, the weight of evidence indicates that we are dealing with a liver function.…”

Snippets from the Past: 70 Years Ago in the Journal

“…The "pharmacology and toxicology of tetrachlorethylene," addressed by Lamson et al (16), was a timely topic in the 1920s, when hookworms and other intestinal worms were still common in much of this country as well as in the less developed parts of the world. The commonly used vermifuges of the day, carbon tetrachloride and oil of chenopodium, were toxic, and safer alternatives were badly needed.…”