Liver Function as Tested by the Lipemic Curve After Intravenous Fat Administration 1

Nachlas, Arthur; Duff, G. W.; Tidwell, Herbert C.; Holt, L. Emmett

doi:10.1172/jci100753

Cited by 9 publications

(2 citation statements)

References 4 publications

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“…Patients zwith hepatic diseases. The fact has been demonstrated that patients with hepatic cirrhosis no longer can properly metabolize intravenously administered fat (3). However, no data are available to indicate whether or not these patients likewise might suffer from any impaired ability to absorb fat from their gastro-intestinal tracts.…”

Section: Clinical Materialsmentioning

confidence: 99%

Metabolic Studies in Patients With Gastro-Intestinal Cancer. Iv. Fat Metabolism, a Method of Study 1

Rekers¹,

Abels²,

Rhoads³

1943

J. Clin. Invest.

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The results of recent studies have added significantly to the understanding of the intermediary metabolism of fat, particularly as concerns the role of the liver in the utilization of fat by the body. (I to 3). On the other hand, the available information concerning the absorption and digestion of fat in the gastro-intestinal tract leaves much to be desired, primarily because of a lack of satisfactory technical methods.In the course of an investigation of the metabolism of essential dietary factors by patients with gastro-intestinal cancer (4, 5), the ability of these patients to digest and absorb fats was determined. For The patients were allowed a preliminary period of from 3 to 5 days on these diets before any studies were begun, in order that they might become accustomed to the rigid routines employed in their feedings and in the collection of their excreta.When each subject had taken the basal diet satisfactorily for from 6 to 9 days, a supplement of fat was given in order to obtain a measure of the individual's ability to absorb fat, at both a normal and high level of fat ingestion. This supplement consisted of 2 grams of fat per kilogram of body weight (the "fat load"). other time. However, on the day when the fat load was stearin determinations were made on samples administered, the meals were taken at 1 p.m., 4 p.m., and which were removed by a large bore pipette from 7 p.m. different levels of suspension. Differences of from b. Collection of feces. When the subject had taken 1 to 4.5 per cent were found between the stearin the basal diet for from 3 to 5 days, a saline enema of content of the various aliquots (Table I). Thus, 500 ml. was given at 7 a.m. and the returns discarded. From that hour, all stools excreted were collected, for

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Section: Clinical Materialsmentioning

confidence: 99%

Metabolic Studies in Patients With Gastro-Intestinal Cancer. Iv. Fat Metabolism, a Method of Study 1

Rekers¹,

Abels²,

Rhoads³

1943

J. Clin. Invest.

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“…well established fact that the liver is concerned intimately in the intermediary metabolism of lipoids (21) and that in many conditions associated with hepatic damage there occurs a striking accumulation of fat in the liver ceils. An increase in the concentration of neutral fat and a decrease of phospholipids has been found especially in the livers of patients with alcoholic hepatic cirrhosis (22), and in animals given various toxic agents (23).…”

Section: The Hepatic Concentration Of Total Lipid and Phospholipid--mentioning

confidence: 99%

Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Abels

Gorham

Eberlin

et al. 1942

Journal of Experimental Medicine

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1. The decreased concentrations of vitamin A in the livers of rats given dibenzanthracene probably are due to a particular effect of the carcinogen on the ability of the liver to store the vitamin and not to the production of general hepatic dysfunction. 2. The administration of dibenzanthracene to normal rats does not (a) increase significantly their hepatic content of total fat nor decrease that of phospholipid; (b) impair the ability of their livers to fabricate serum albumin; (c) impair the capacity of their livers to esterify cholesterol or phenol; (d) interfere with the hepatic synthesis and conjugation of glucuronic acid; or (e) interfere with the hepatic storage of riboflavin. 3. The simultaneous ingestion of yeast by the dibenzanthracene-treated rats further depletes their hepatic stores of vitamin A. This depletion conceivably is due to the fact that yeast alone also might deplete the liver of its vitamin A and thus a summation of two similar effects is attained. 4. The results suggest a competition between vitamin A and dibenzanthracene for some substance, possibly a protein, to which vitamin A may be bound in the liver.

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Liver and Biliary Tract

Greene¹,

Handelsman²,

Babey³

1937

Arch Intern Med (Chic)

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Liver Function as Tested by the Lipemic Curve After Intravenous Fat Administration 1

Cited by 9 publications

References 4 publications

Metabolic Studies in Patients With Gastro-Intestinal Cancer. Iv. Fat Metabolism, a Method of Study 1

Metabolic Studies in Patients With Gastro-Intestinal Cancer. Iv. Fat Metabolism, a Method of Study 1

Hepatic Vitamin a in the Rat as Affected by the Administration of Dibenzanthracene

Liver and Biliary Tract

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