The pharmacokinetics and metabolism of sucralose in the mouse

John, B. A.; Wood, Simon; Hawkins, David R.

doi:10.1016/s0278-6915(00)00032-6

Cited by 55 publications

(28 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case of NAS, one may consider a direct effect, in which bacteria that can metabolize NAS as energy source thrive, while others may experience toxicity. Such a direct effect is indeed plausible in the case of saccharin and sucralose, as both are largely not metabolized by the host's body 35,57 and have been previously demonstrated to affect the growth of certain bacteria. [58][59][60] Our findings suggest such direct effect of saccharin on the microbiome, and functional analysis of the saccharin-associated metagenome indicated that several pathways involved in metabolism of heterocyclic compounds were enriched, suggesting that saccharin exposure may have been associated with expansion of bacteria capable of utilizing it.…”

Section: Challenges: Toward Mechanistic Understanding Of Nas Effectsmentioning

confidence: 92%

“…Most NAS are excreted unchanged from the mammalian body, and therefore considered metabolically 'inert' [33][34][35] with no physiological effect exerted on the mammalian host. While these 2 notions form the foundation for the endorsement of NAS use, lack of NAS metabolism by the host does not rule out the possibility that these compounds may interact with the gut microbiome.…”

Section: Nas and The Microbiomementioning

confidence: 99%

See 1 more Smart Citation

Non-caloric artificial sweeteners and the microbiome: findings and challenges

et al. 2015

View full text Add to dashboard Cite

These authors equally contributed to this work. N on-caloric artificial sweeteners (NAS) are common food supplements consumed by millions worldwide as means of combating weight gain and diabetes, by retaining sweet taste without increasing caloric intake. While they are considered safe, there is increasing controversy regarding their potential ability to promote metabolic derangements in some humans. We recently demonstrated that NAS consumption could induce glucose intolerance in mice and distinct human subsets, by functionally altering the gut microbiome. In this commentary, we discuss these findings in the context of previous and recent works demonstrating the effects of NAS on host health and the microbiome, and the challenges and open questions that need to be addressed in understanding the effects of NAS consumption on human health.

show abstract

Section: Challenges: Toward Mechanistic Understanding Of Nas Effectsmentioning

confidence: 92%

Section: Nas and The Microbiomementioning

confidence: 99%

Non-caloric artificial sweeteners and the microbiome: findings and challenges

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Studies performed on the metabolism of sucralose showed that when administered orally to mice at doses of 1000, 1500 and 3000 mg/kg body weight/day, urinary elimination averaged, respectively 23%, 15% and 16%, indicating that even with augmented administration of sucralose, there is no corresponding rise in absorption [12,13]. Studies indicate the existence of 2 hydrolysis products of sucralose, 4-chloro-4-deoxy-Dgalactose (4-CG) and 1,6-dichloro-1-6-dideoxy-D-fructose (1,6-DCG) that are more rapidly absorbed after oral administration than the original sucralose compound.…”

Section: Introductionmentioning

confidence: 99%

Biological Effect of Sucralose in Diabetic Rats

Saada¹,

Mekky²,

Eldawy³

et al. 2013

FNS

View full text Add to dashboard Cite

Among people that might take a large amount of sucralose, are diabetic people who are attempting to modify their carbohydrate intake. The objective of this study is to evaluate the impact of sucralose; an artificial sweetener derived from sucrose, at a dose approximately twice the ADI on hyperglycemia, hyperlipidemia and oxidative stress in diabetic rats. Diabetes was induced in male albino rats after an intraperitoneal streptozotocin injection (65 mg/kg body weight). Animals with fasting blood glucose levels ≥250 mg/dl were considered diabetics. Sucralose was dissolved in water and administered to rats daily by oral gavages during a period of 6 weeks at a dose of 11 mg/kg body weight. Animals were divided into 4 groups and treated in parallel for 6 weeks. Control: rats received distilled water, Sucralose: rats received sucralose, Diabetic: diabetic rats received distilled water, Diabeticrats + Sucralose: diabetic rats received sucralose. The administration of sucralose to diabetic rats provoked a significant decrease (P < 0.05) of serum glucose and triglyceride levels, a significant increase (P < 0.05) of total cholesterol, low density lipoprotein-cholesterol (LDL-C), and high density lipoprotein-cholesterol (HDL-C), while has no effect (P > 0.05) on insulin, compared to their respective values in diabetic rats receiving distilled water. Biochemical analysis in brain and testis tissues showed that sucralose has no effect (P > 0.05) on superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), and glucose-6-phosphate dehydrogenase (G-6-PDH) activities, and glutathione content (GSH), while reduced thiobarbituric acid reactive substances level (TBARS) (P < 0.05), compared to their respective values in diabetic rats receiving distilled water. It could be concluded that consumption of sucralose didn't induce oxidative stress, has no effect on insulin, reduce glucose absorption and intensify hypercholesterolemia in STZ-induced diabetic rats. Accordingly it is advised that diabetic people consuming high amount of sucralose must check their lipid profile to avoid diabetic complications.

show abstract

“…Students should also take into consideration evidence from the study discussed in Questions 4 and 5 where an average of 92.8% of radioactivity from 14 C-sucralose was recovered within 5 days indicating the only metabolism of sucralose in humans involves glucuronidation [4]. These results have been supported by studies in dogs, mice, and rats [15][16][17]. 7) Sucralose is a halogenated compound.…”

mentioning

confidence: 91%

Is sucralose too good to be true?

Thomas

2011

Biochem Molecular Bio Educ

View full text Add to dashboard Cite

Student interest in artificial sweeteners can enhance the biochemistry classroom learning experience. This in class, guided-inquiry activity focuses on sucralose and fits into a 50-min biochemistry class for undergraduate science majors. Background knowledge of carbohydrate structure, function, and metabolism as well as familiarity with interpretation of primary literature is assumed. This activity uses short answer questions that stimulate small group discussion.

show abstract

The pharmacokinetics and metabolism of sucralose in the mouse

Cited by 55 publications

References 2 publications

Non-caloric artificial sweeteners and the microbiome: findings and challenges

Non-caloric artificial sweeteners and the microbiome: findings and challenges

Biological Effect of Sucralose in Diabetic Rats

Is sucralose too good to be true?

Contact Info

Product

Resources

About