The pH-induced physical properties of ionic contact lens material

Ahn, Jihye; Choi, Moonsung

doi:10.1016/j.heliyon.2023.e12996

Cited by 2 publications

(7 citation statements)

References 30 publications

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“…These hydrogels can undergo controlled swelling and exhibit tunable mechanical properties, allowing them to mimic the physical and mechanical properties of natural tissues [190,191]. Additionally, hydrogels can be engineered to respond to external stimuli such as changes in temperature [192,193], pH [193,194], or light, making them valuable for applications such as targeted drug delivery or biosensing [13,15,69,103].…”

Section: Polymer-based Hydrogelsmentioning

confidence: 99%

“…They are responsible for imparting an ionic charge to the hydrogel. When the hydrogel is immersed in water or an aqueous environment these charged groups can dissociate, releasing charged ions into the surrounding solution [174,194,217]. The presence of these charged ions enables interactions with oppositely charged species in the environment.…”

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

“…The presence of these charged ions enables interactions with oppositely charged species in the environment. Ionic polymer-based hydrogels can be classified into two main types: cationic polymerbased hydrogels and anionic polymer-based hydrogels, based on the type of charged functional groups they possess [194,216,217]. The cationic polymer-based hydrogels contain positively charged functional groups, typically amine groups.…”

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

“…The pH responsiveness of ampholytic polymer-based hydrogels arises from the ionization of the charged groups in response to changes in pH [218,219]. When the pH of the surrounding medium changes, the charged groups within the hydrogel can either gain or lose protons, leading to alterations in the overall charged density of the polymer-based hydrogel network [191,193,194]. This change in charged density affects the electrostatic interactions within the hydrogel and influences its swelling behavior and mechanical properties.…”

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

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Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

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Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Current trends in the development of hydrogel drug delivery systems involve the release of drugs in response to specific triggers such as pH, temperature, or enzymes for targeted drug delivery and to reduce the potential for systemic toxicity. In addition, developing injectable hydrogel formulations that are easily used and sustain drug release during this extended time is a growing interest. Another emerging trend in hydrogel drug delivery is the synthesis of nano hydrogels and other functional substances for improving targeted drug loading and release efficacy. Following these development trends, advanced hydrogels possessing mechanically improved properties, controlled release rates, and biocompatibility is developing as a focus of the field. More complex drug delivery systems such as multi-drug delivery and combination therapies will be developed based on these advancements. In addition, polymer-based hydrogels are gaining increasing attention in personalized medicine because of their ability to be tailored to a specific patient, for example, drug release rates, drug combinations, target-specific drug delivery, improvement of disease treatment effectiveness, and healthcare cost reduction. Overall, hydrogel application is advancing rapidly, towards more efficient and effective drug delivery systems in the future.

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Section: Polymer-based Hydrogelsmentioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

Section: Classification Of Polymer-based Hydrogels Based On Ionic Chargementioning

confidence: 99%

See 2 more Smart Citations

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Nguyen

Chien

Cường

2023

Gels

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“…Bulk polymerization of polyHEMA hydrogel-based contact lenses frequently results in poor optical transmittance [ 20 , 21 ]. Therefore, incorporating other hydrophilic materials, such as methacrylic acid, N-vinyl-2-pyrrolidone, acrylamide, or sulfobetaine methacrylate, into the polyHEMA network is a common strategy to enhance their performance [ 21 , 22 , 23 ]. Nevertheless, the high water content alters the microstructural environment of the polymer network and diminishes its mechanical properties [ 21 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents

2023

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Poly(2-hydroxyethyl methacrylate) (polyHEMA) hydrogels are commonly used in biomaterials such as contact lenses. However, water evaporation from these hydrogels can cause discomfort to wearers, and the bulk polymerization method used to synthesize them often results in heterogeneous microstructures, reducing their optical properties and elasticity. In this study, we synthesized polyHEMA gels using a deep eutectic solvent (DES) instead of water and compared their properties to traditional hydrogels. Fourier-transform infrared spectroscopy (FTIR) showed that HEMA conversion in DES was faster than in water. DES gels also demonstrated higher transparency, toughness, and conductivity, along with lower dehydration, than hydrogels. The compressive and tensile modulus values of DES gels increased with HEMA concentration. A DES gel with 45% HEMA showed excellent compression–relaxation cycles and had the highest strain at break value in the tensile test. Our findings suggest that DES is a promising alternative to water for synthesizing contact lenses with improved optical and mechanical properties. Furthermore, DES gels’ conduction properties may enable their application in biosensors. This study presents an innovative approach to synthesizing polyHEMA gels and provides insights into their potential applications in the biomaterials field.

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The pH-induced physical properties of ionic contact lens material

Cited by 2 publications

References 30 publications

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents

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