2023
DOI: 10.3390/gels9070523
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Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Abstract: Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts of water and biological fluids and control drug release based on their unique physicochemical properties and biocompatibility. Current trends in the development of hydrogel drug delivery systems involve the release of drugs in response to specific triggers such as pH, temperature, or enzymes for targeted drug delivery and to reduce the potential f… Show more

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Cited by 77 publications
(46 citation statements)
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“…Moreover, some hydrogels contain both cationic and anionic polymers in their structure and can demonstrate both acidic and basic properties, called ampholytic or zwitterionic hydrogels. 26,27 Hydrogels have gained interest in several applications, including drug delivery, tissue engineering, and surface coating, as shown in Table 1. Due to several kinds of hydrogels, they have unique properties, such as porosity, 28,29 swollen, 30 mechanical strength (e.g., stiffness, viscoelasticity, and permeability), 31 biocompatibility, biodegradability, and microorganisms sensing, which provide an advantage for versatile applications.…”
Section: Classification and Application Of Hydrogelsmentioning
confidence: 99%
“…Moreover, some hydrogels contain both cationic and anionic polymers in their structure and can demonstrate both acidic and basic properties, called ampholytic or zwitterionic hydrogels. 26,27 Hydrogels have gained interest in several applications, including drug delivery, tissue engineering, and surface coating, as shown in Table 1. Due to several kinds of hydrogels, they have unique properties, such as porosity, 28,29 swollen, 30 mechanical strength (e.g., stiffness, viscoelasticity, and permeability), 31 biocompatibility, biodegradability, and microorganisms sensing, which provide an advantage for versatile applications.…”
Section: Classification and Application Of Hydrogelsmentioning
confidence: 99%
“…Hydrogels are particularly helpful as wound care dressings since they create and maintain a moist environment regardless of external conditions. 53 By promoting cell proliferation, vascularization, and host integration, they offer an environment that is advantageous for wound healing. In addition, hydrogels offer beneficial properties such as effective oxygen transport, biocompatibility, biodegradability, high swelling capacity for absorbing wound exudate, antibacterial activities, and nontoxicity.…”
Section: Wound Healing Dressingsmentioning
confidence: 99%
“…Natural hydrogels are fabricated from macromolecules and polymers of natural origin, such as collagen, alginate, fibrin, chitosan, hyaluronic acid, and gelatin, which are biocompatible and biodegradable and often exhibit inherent bioactivity. 127,128 Chen et al developed an in situ sprayable hydrogel containing fibrin and anti-CD47 antibody (aCD47)-loaded CaCO 3 nanoparticles that can release CaCO 3 nanoparticles in a sustained manner. 129 Similarly, macroporous alginate hydrogel scaffolds were used for the treatment of poorly immunogenic breast cancers and melanoma together with GM-CSF, CpG ODN, and anti-PD-1 antibody.…”
Section: Biomaterial-based Sustained-release Platforms Developed For ...mentioning
confidence: 99%
“…Hydrogels can be broadly classified into natural or synthetic hydrogels based on the source of polymers. Natural hydrogels are fabricated from macromolecules and polymers of natural origin, such as collagen, alginate, fibrin, chitosan, hyaluronic acid, and gelatin, which are biocompatible and biodegradable and often exhibit inherent bioactivity. , Chen et al developed an in situ sprayable hydrogel containing fibrin and anti-CD47 antibody (aCD47)-loaded CaCO 3 nanoparticles that can release CaCO 3 nanoparticles in a sustained manner . CaCO 3 nanoparticles scavenge H + in the acidic TME and consequently are dissolved and release aCD47, which together promote M1 polarization of macrophages and their phagocytosis of cancer cells.…”
Section: Biomaterial-based Sustained-release Platforms Developed For ...mentioning
confidence: 99%
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