The peripheral giant cell reparative granuloma

Bernier, Joseph L.; Cahn, Lester R.

doi:10.14219/jada.archive.1954.0138

Cited by 80 publications

(49 citation statements)

References 5 publications

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“…[5] PGCG is a relatively frequent benign reactive lesion of the oral cavity, originating from the periosteum or periodontal membrane following local irritation or chronic trauma. [3] Ultrastructural and immune studies have shown the giant cells to derive from macrophages and the role of myofibroblasts in PGCG.…”

Section: Discussionmentioning

confidence: 99%

Conservative surgical excision of peripheral giant cell granuloma: A clinico-histopathological study

Mishra¹,

Bisane²

2014

sjod

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Peripheral giant cell granuloma (PGCG) is an infrequent exophytic lesion of the oral cavity, also known as giant cell epulis, giant cell reparative granuloma, or giantcell hyperplasia. Commonly known causes are local irritation due to dental plaque or calculus, periodontal disease, poor dental restorations, ill-fitting appliances or dental extractions. The suggested treatment is conservative excision and the lesion has a 10-15% recurrence rate. The aim in publishing this report is to present the clinical, histopathological features and treatment of a PGCG case, which was seen on gingiva and disturbed chewing functions. The lesion was completely excised to the periosteum level and there is no residual or recurrent, swelling or bony defect apparent in the area after a follow-up period of 1 year.

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Section: Discussionmentioning

confidence: 99%

Conservative surgical excision of peripheral giant cell granuloma: A clinico-histopathological study

Mishra¹,

Bisane²

2014

sjod

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“…[2] Bernier Cahn suggested that these lesions should be called as either a peripheral or central giant cell reparative granuloma. [3] Today the term PGCG is universally accepted. [4] Waldron and Shafer found that the intra-osseous lesions did not contain any reparative characteristics and histologically did not differ from any other benign giant cell tumor of bone.…”

Section: Historical Backgroundmentioning

confidence: 99%

“…[11] In 1962, Gottsegen [12] proposed that PGCG arose postperiodontal surgery while others claimed that they developed in response to local irritating factors. [2][3][4] One of the predisposing factors causing PGCG is poor oral hygiene, and it is most commonly found in people belonging to the lower socioeconomic strata. [13] PGCG occurs exclusively on the gingiva or edentulous alveolar ridge.…”

Section: Historical Backgroundmentioning

confidence: 99%

Peripheral giant cell granuloma: A comprehensive review of an ambiguous lesion

Patil

Kalele²,

Kanakdande

2014

J Int Clin Dent Res Organ

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Peripheral giant cell granuloma (PGCG) is a non-neoplastic, tumor-like reactive lesion occurring exclusively on gingiva/alveolar crest. It is thought to arise from the periodontal ligament or the periosteum. Clinically, it bears resemblance to pyogenic granuloma, peripheral ossifying fibroma and many other peripheral lesions seen in the oral cavity, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, but still carries a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells and its treatment. The entity further holds significance because of its notorious behavior and its high tendency to recur. The present paper describes recurrent PGCG with a comprehensive insight of the literature on its etiology, clinical, radiological, histological, ultrastructural and molecular aspects. Special attention is given on the histogenesis of cells and their types as also on the differential diagnosis and treatment of this lesion.

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“…PGCG is thought to originate from the interdental tissue (periosteum or periodontal ligament) following local irritation. Periodontal disease with varying amount of subgingival plaque and calculus too act as an important local irritant factor 2,3,4 . Rapidly Progressing Periodontitis (RPP) is usually seen in young adults with a female predilection.It is a multifactorial disease and mixed factors as oral flora, immunological response of patient and environment decide the severity, course and onset of the disease 5,6,7 .…”

Section: Introductionmentioning

confidence: 99%