The Perinatal Outcomes of Asymptomatic Isolated Single Umbilical Artery in Full-term Neonates

Mu, Shu Chi; Lin, Cheng Hui; Chen, Yi Ling; Sung, Tseng-Chen; Bai, Chyi Huey; Jow, Guey–Mei

doi:10.1016/s1875-9572(09)60016-4

Cited by 37 publications

(36 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The incidence in most studies is 0.2 to 1.6% (euploid) to 9 to 10% (anueploid pregnancies). 8 In our study the incidence was 0.88 per 100 pregnancies. SUA is associated with congenital anomalies.…”

Section: Discussionsupporting

confidence: 46%

Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Lnu¹,

Vasanthalakshmi²,

Mehta³

et al. 2012

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

Objective: To study the pregnancy outcome of antenatal women diagnosed with single umbilical artery (SUA) in singleton pregnancy in tertiary medical center and its association with intrauterine growth restriction (IUGR), renal and cardiac anomalies. Materials and methods:We performed a prospective study of 6,711 singleton pregnancies at Sri Ramachandra Medical College, Chennai, between July 2009 and June 2011 and the pregnancies diagnosed with SUA were followed. The primary outcomes were renal anomalies, cardiac anomalies and IUGR.Results: Of the 6,711 pregnancies there were 59 (0.88%) cases of SUA diagnosed at anatomic survey. Thirty seven pregnancies had isolated SUA (62.7%) and 22 singleton pregnancies had associated malformations (37.2%). Conclusion:Our data suggests that the prevalence of SUA and associated anomalies seems to be similar to that reported in other countries. Evaluating cord vessels is important and fetuses with isolated SUA need more detailed assessment and monitoring 1 including Doppler study in the presence of IUGR. SUA with multiple anomalies need further evalution with fetal echocardiogram and invasive tests like amniocentesis for karyotyping.

show abstract

Section: Discussionsupporting

confidence: 46%

Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Lnu¹,

Vasanthalakshmi²,

Mehta³

et al. 2012

Journal of South Asian Federation of Obstetrics and Gynaecology

View full text Add to dashboard Cite

show abstract

“…Based on these findings, some authors have recommended that fetal growth should be monitored throughout pregnancy after prenatal diagnosis of a single umbilical artery. [7][8][9]11,12 As a matter of fact, throughout the study period, our management protocol for pregnancies diagnosed with ISUA included serial follow up fetal growth scans. And when fetal growth restriction was diagnosed additional fetal well being tests were performed.…”

Section: Discussionmentioning

confidence: 99%

“…Compensatory mechanisms allow increase in blood flow through the single artery in order to meet the demands of fetal growth and development throughout pregnancy. 3 Although several studies have reported diminished fetal growth in these pregnancies, [4][5][6][7][8][9][10][11][12] others have not shown differences. [13][14][15] These contradictory findings may be attributed to diverse methodological differences in the published literature.…”

Section: Introductionmentioning

confidence: 99%

Should fetal growth be a matter of concern in isolated single umbilical artery?

Caldas¹,

Liao²,

Carvalho³

et al. 2014

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

Should fetal growth be a matter of concern in iSolated Single umbilical artery? rev aSSoc med braS 2014; 60(2):125-130 125original articleShould fetal growth be a matter of concern in isolated single umbilical artery? Conflict of interest: noneObjective: To examine birth weight in pregnancies with isolated single umbilical artery (ISUA). Methods: Case control study with retrospective review of 131 singleton pregnancies with isolated single umbilical artery diagnosed before birth. Control group consisted of 730 singleton pregnancies recruited prospectively, that had histological confirmation of a 3 vessels cord. Pregnancies were classified as uncomplicated or high-risk according to the presence of diseases that increase the risk of placental insufficiency during pregnancy. Mean birth weight and frequency of low birth weight (< 2.500 g), very low birth weight (< 1.500 g) and fetal growth restriction below the 5 th and 10 th centiles were compared between groups. Results: Mean birth weight difference between ISUA (n=131, 2840±701g) and control (n=730, 2.983 ± 671g) pregnancies was 143g (95% CI= 17-269; p=0.04) and birth weight below the 5 th centile was significantly more common in ISUA group [28/131 (21.4%) versus 99/730 (13.6%), p=0.02]. When only uncomplicated pregnancies were considered in both groups, no birth weight differences were observed. Amongst high-risk subgroups, birth weight below the 5 th centile remained significantly more common in ISUA compared to control pregnancies [10/35 (28.6%) versus 53/377 (14.1%), p=0.04]. Conclusion: Isolated single umbilical artery does not increase the risk of fetal growth restriction in uncomplicated singleton pregnancies.

show abstract

“…Perinatal outcomes that have been evaluated previously in the literature include birthweight, gestational age at delivery, fetal anomalies, and neonatal intensive care unit admissions. 2,6,7 Although the association between antenatal ultrasound findings and birth outcomes has been evaluated, there have been no data regarding long-term outcomes in affected infants. Our study aims to identify whether there are any long-term implications of SUA on physical and neurologic development.…”

mentioning

confidence: 99%

Long-term physical and neurologic development in newborn infants with isolated single umbilical artery

Chetty-John

Zhang

Chen

et al. 2010

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

OBJECTIVE This study compared birth parameters and the longitudinal course in physical and neurologic development between children with 2 and 3 vessel umbilical cords. STUDY DESIGN Our study of the Collaborative Perinatal Project included singletons of at least 24 weeks’ gestation with single umbilical artery at birth and no identifiable congenital anomalies. Demographics that were collected included maternal age, race, smoking status, and socioeconomic index. Delivery data included gestational age, birth-weight, Apgar scores, placental weight, and umbilical cord insertion and length. Growth and neurodevelopmental parameters were collected at various intervals from birth to 7 years. RESULTS There were 263 infants with isolated single umbilical artery and 41,415 infants with 3 vessel cords. A random effect model that controlled for potential confounders did not show clinically significant differences in the physical and neurodevelopment measures between these groups. CONCLUSION Our study shows no evidence of differential longitudinal physical growth or neurologic outcomes between infants with 2 or 3 vessel cords.

show abstract

The Perinatal Outcomes of Asymptomatic Isolated Single Umbilical Artery in Full-term Neonates

Cited by 37 publications

References 10 publications

Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Should fetal growth be a matter of concern in isolated single umbilical artery?

Long-term physical and neurologic development in newborn infants with isolated single umbilical artery

Contact Info

Product

Resources

About