Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Lnu, Pushpalatha; Vasanthalakshmi, Gonnabaktula Naga; Mehta, Priyanka; Devi, Sumangala

doi:10.5005/jp-journals-10006-1185

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…Other malformations, such as tetralogy of Fallot, coarctation of the aorta, and hypoplastic left ventricle, were also described. Furthermore, to a lesser extent, the atrioventricular canal, hypoplastic right ventricle, and double outflow tract of the right ventricle, among others, are consistent with what has been reported in the literature (Araujo Júnior et al, 2015;Chen et al, 2016;Gossett et al, 2002;Vasanthalakshmi et al, 2012).…”

Section: Discussionsupporting

confidence: 90%

“…We found 1384 studies by the search strategy used; after carefully reviewing the full‐text, we finally included 15 studies for analysis (Araujo Júnior et al, 2015; Chen et al, 2014; Chen et al, 2016; DeFigueiredo et al, 2010; Gossett et al, 2002; Gurram et al, 2018; Lee et al, 1998; Miller & Towner, 2019; Prefumo et al, 2010; Sun & Wang, 2018; Tasha et al, 2014; Tonismae et al, 2021; Vasanthalakshmi et al, 2012; Wang et al, 2019; Xin et al, 2014) (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

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Incidence of congenital heart disease in fetuses diagnosed with single isolated umbilical artery. Systematic review and meta‐analysis

Solano M.,

García‐Perdomo

2023

Birth Defects Research

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ObjectiveTo estimate the proportion of heart disease in fetuses with a prenatal diagnosis of a single isolated umbilical artery.MethodsWe performed a search strategy in MEDLINE (OVID), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to the present. We assessed the risk of bias and performed a meta‐analysis. We completed the subgroup analysis according to the region.ResultsWe found 1384 studies by the search strategy. After carefully reviewing the full‐text, 15 studies were included. A total of 2008 fetuses with a single isolated umbilical artery were included, and 177 had cardiac malformations. There was an overall incidence of 9% 95%CI (0.05–0.14) I2 90%. The incidence by country of origin was between 5% and 19%. The most common heart disease reported was a ventricular septal defect. Seven studies were found describing 25 cases. We described other malformations, such as tetralogy of Fallot, coarctation of the aorta, and hypoplastic left ventricle, among others.ConclusionThe incidence of congenital heart disease in fetuses with a single isolated umbilical artery was high. In addition, half of these correspond to significant heart disease. Based on the above, we suggest that fetuses with a single isolated umbilical artery should have a complete anatomic evaluation emphasizing cardiac evaluation.

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Section: Discussionsupporting

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Incidence of congenital heart disease in fetuses diagnosed with single isolated umbilical artery. Systematic review and meta‐analysis

Solano M.,

García‐Perdomo

2023

Birth Defects Research

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Sirenomelia: two cases in Cali, Colombia

2015

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We report two cases of sirenomelia, a rare congenital defect with a prevalence rate of 1:100 000 births; both cases were observed in Cali, Colombia. Both pregnant women were referred from Buenaventura, Colombia. The expecting mothers shared multiple adverse sociodemographic factors. Their homes were located in a city where the entire population is of low socioeconomic status living under conditions of extreme poverty. They were uneducated, with nutritional deficiencies and no access to drinking water most of the time. Both were exposed to water and fish from a nearby river contaminated with leachate from a poorly managed landfill. A similar relation was previously reported in Cali in 2005 between environmental factors and sirenomelia. We suggest that there is a common aetiological factor of environmental origin between these two sirenomelia cases and propose that exposure to derivatives from landfills should be included among the factors for this rare defect of multifactorial aetiological origin.

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A Study of Correlation Between Placental and Umbilical Cord Abnormalities and Foetal Outcome of Patients Delivering at a Tertiary Care Hospital

Nallasivam¹,

Kuruvila²

2016

jebmh

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It has been estimated that 30% of births have some type of umbilical cord abnormalities. Disruption of the umbilical cord supply line is a major source of harm to the developing foetus. It is estimated that every third to fourth delivery has an identifiable umbilical cord abnormality or anomaly. What is unknown is how these findings affect the foetus and to what extent. Hence, the placenta and umbilical cord needs to be evaluated. AIM OF THE STUDY To study the correlation between the foetal outcome and the different types of abnormalities of placenta and umbilical cord. METHODS AND MATERIALS This descriptive study was done during the period October 2010 to December 2011 in a tertiary care centre. All consecutive patients who delivered at the institution during this period were included in the study. Those placentas where the anatomy of the cord could not be clearly identified were excluded from the study. RESULTS 26.6% of the placentas examined showed some abnormality. Abnormalities of the cord was present in 78 cases (7.8%). One cord had five vessels-four arteries and one vein. Foetal abnormalities were more common in those who had a placental or cord anomaly also. CONCLUSIONS No significant correlation between placental abnormalities and foetal anomalies could be obtained. There was a higher incidence of adverse foetal outcome with cord abnormalities. An accurate antenatal evaluation could be of help in anticipating adverse perinatal outcomes in selected cases.

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Single Umbilical Artery and Pregnancy Outcome: Cause for Concern

Cited by 3 publications

References 9 publications

Incidence of congenital heart disease in fetuses diagnosed with single isolated umbilical artery. Systematic review and meta‐analysis

Incidence of congenital heart disease in fetuses diagnosed with single isolated umbilical artery. Systematic review and meta‐analysis

Sirenomelia: two cases in Cali, Colombia

A Study of Correlation Between Placental and Umbilical Cord Abnormalities and Foetal Outcome of Patients Delivering at a Tertiary Care Hospital

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