The Penetration of Aureomycin, Terramycin and Chloramphenicol in the Ocular Tissues

Ocular Pharmacokinetics

“…Systemic antibiotics are usually either undetectable or recoverable only in trace amounts from the lens after systemic administration (Table 7). More lipid-soluble drugs, such as chloramphenicol (BLEEKER and MAAS 1955), benzylpenicillin (SALMINEN et al 1969), and tetracycline (SALMINEN 1977 a), seem to soak into the lens more rapidly. The systemic injection of rhodamine B, a lipidsoluble dye, quickly stains the cortex of the lens, which then shows in the slit lamp as the most fluorescent structure in the eye.…”

Ocular antimicrobial therapy in small animal practice

“…When injected subconjunctivally the type of preparation influenced ocular penetration. The sodium succinate salt and aqueous solutions penetrated poorly, but a preparation in propylene glycol resulted in high intraocular levels (Bleeker and Mass 1955, McPherson and others 1968).…”

Distribution of Tritiated Tetracycline in the Rabbit Eye

“…Parenteral injection of 20 to 30 mg/kg of tetracycline resulted in measurable concentrations in the rabbit aqueous, but not in the vitreous body (Furgiuele 1964); chlortetracycline could not be found even in the aqueous (Douvas et al 1951). In other studies, chlortetracycline as well as demethylchlortetracycline have, however, been detected in the rabbit aqueous humor after oral administration, and chlortetracycline also in other parts of the rabbit eye ( Bleeker & Maas 1955, Knothe 1959. Antibiotic concentrations in all these studies have been determined using microbiological methods, which cannot be applied to infected specimens.…”