The Pellicle and Erosion

Hannig, Matthias; Hannig, Christian

doi:10.1159/000360376

Cited by 120 publications

(139 citation statements)

References 48 publications

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“…As previously established in the literature, saliva plays an important role in reducing erosive tooth wear before an erosive/abrasive attack [Amaechi and Higham, 2001] due to the formation of the salivary pellicle [Hannig, 2002;Hara et al, 2006]. The salivary pellicle has been described as a semipermeable membrane rich in proteins with acid-protective properties [Hannig and Hannig, 2014]. In the present study, after the formation of the salivary pellicle, the appliance was kept out of the mouth for 1 h, and this may have modified some of its proteins.…”

Section: Discussionsupporting

confidence: 51%

In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge

Jordão¹,

Alencar²,

Mesquita³

et al. 2016

Caries Res

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The erosion-protective effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is controversial. This study aimed to investigate the ability of CPP-ACP chewing gum to prevent a single event of erosive demineralization in situ. Bovine enamel blocks (n = 120) were randomly assigned to 3 phases according to the baseline surface hardness: phase I (PI) - chewing gum with CPP-ACP, phase II (PII) - chewing gum without CPP-ACP, and control phase (PIII) - salivary effect without stimulation (no gum). Nineteen volunteers participated in this study during 3 crossover phases of 2 h. In PI and PII, the volunteers wore intraoral palatal appliances for 120 min and chewed a unit of the corresponding chewing gum for the final 30 min. In the control phase the volunteers wore the appliance for 2 h, without chewing gum. Immediately after intraoral use, the appliances were extraorally immersed in a cola drink for 5 min to promote erosive demineralization. The percentage of surface hardness loss was calculated. The data were analyzed by ANOVA models and Tukey's test. Lower enamel hardness loss was found after the use of chewing gum with CPP-ACP (PI: 32.7%) and without CPP-ACP (PII: 33.5%) compared to the salivary effect without stimulation (PIII: 39.8%) (p < 0.05). There was no difference between PI and PII (p > 0.05). The results suggest that the use of chewing gum immediately before an erosive demineralization can diminish enamel hardness loss. However, the presence of CPP-ACP in the chewing gum cannot enhance this protective effect.

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Section: Discussionsupporting

confidence: 51%

In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge

Jordão¹,

Alencar²,

Mesquita³

et al. 2016

Caries Res

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“…The acquired pellicle has been shown to have properties that may protect the enamel against mild erosive challenges in situ [Hara et al, 2006]. However, a recent review concluded that only limited scientific data is available regarding the protective properties of the pellicle against dental erosion [Hannig and Hannig, 2014].…”

Section: Discussionmentioning

confidence: 99%

The Susceptibility to Dental Erosion Differs among Individuals

Uhlen¹,

Mulic²,

Holme³

et al. 2016

Caries Res

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Studies of wine tasters and patients with self-induced vomiting have revealed that 30-50% of individuals at high risk do not develop erosive lesions. The aim was to investigate this apparent individual susceptibility to enamel erosion. Two enamel specimens were made from each of 3 premolars from 8 persons (donors). Six acrylic mouth appliances were worn by 6 volunteers (carriers). One specimen from each donor was mounted on each appliance. The carriers wore the appliances for 9 days. The appliances were immersed in 0.01 M HCl for 3 min twice per day to imitate a vomiting/reflux situation. The enamel specimens were analysed by a white-light interferometer to measure enamel loss (in micrometres). The enamel loss varied significantly both between the donor teeth (p = 0.009) and the carriers (p = 0.004). The lesion in the specimen with the largest amount of enamel loss was 4 times as deep as in the specimen with the lowest. In 1 carrier, all specimens displayed enamel loss above the mean, including the specimen from the donor with the most resistant enamel. The variation in susceptibility to erosion among individuals appears to be influenced both by the sustainability of the enamel and by factors in the oral environment. This could explain the variation in prevalence and severity of dental erosions among patients exposed to similar acidic challenges. The results suggest that for certain individuals, only minimal acidic challenges may be sufficient to cause damage to the teeth, while others may never develop dental erosions despite extensive exposure to acid.

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“…Besides the buffering effects of saliva and the clearance of acids in the oral cavity, the interactions at the tooth surface have to be considered, especially the omnipresent pellicle [Hannig and Hannig, 2014]. This physiological coating is formed almost instantaneously on all solid substrata in the oral cavity.…”

mentioning

confidence: 99%

“…The pellicle layer contains many protective and antibacterial components and serves as a lubricant [Hannig and Joiner, 2006]. Furthermore, it acts as a barrier against erosive noxae, but is semipermeable and, therefore, its protective effect is limited [Hannig et al, 2007[Hannig et al, , 2009a[Hannig et al, , 2012Hannig and Hannig, 2014]. Pellicle formation is of high selectivity, and the sustainable immobilization of protective ions and molecules at the tooth surface is rather difficult [Hannig and Joiner, 2006].…”

mentioning

confidence: 99%

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

et al. 2015

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Objectives: Antiadherent and antibacterial effects of certain plant extracts have been proven to be beneficial in preventive dentistry. In the present in situ/in vitro crossover study, the impact of plant extracts rich in polyphenols on the erosion-protective properties of the in situ pellicle was evaluated. Methods: Individual splints were prepared for 12 subjects for intraoral exposure of bovine enamel specimens. Following formation of a 1-min pellicle, watery plant extracts (leaves of the wild form of Ribes nigrum, the wild form of Origanum as well as a combination of both) were administered for 10 min in situ. Alternatively, a mouth rinse with fluorides (Elmex Kariesschutz) was performed for 1 min. After further oral exposure for 19/28 min, respectively, slabs were removed and incubated with HCl in vitro over 120 s (pH 2, 2.3, 3). The resulting calcium and phosphate release was quantified photometrically. Slabs with and without a 30-min in situ pellicle served as controls. The modification of pellicle ultrastructure was evaluated by transmission electron microscopy (TEM). Results: Plant extracts modulated the erosion-protective properties of the native in situ pellicle in all test groups in a pH-dependent manner. The combination of R. nigrum leaves and Origanum enhanced the protective properties of the pellicle at all pH values; the administration of this preparation was comparable, yet superior, to the effect of the fluoridated mouth rinse. TEM images indicated that rinsing with R. nigrum leaves/Origanum yielded a distinctly thicker and more electron-dense pellicle. Conclusion: The combination of certain plant extracts offers a novel approach to the complementary prevention of dental erosion.

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The Pellicle and Erosion

Cited by 120 publications

References 48 publications

In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge

In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge

The Susceptibility to Dental Erosion Differs among Individuals

Application of Plant Extracts for the Prevention of Dental Erosion: An in situ/in vitro Study

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