The Pattern of Tpeak-Tend Interval and QTdis, and Pdis in Children with Brucellosis

Abstract

Objective To investigate the effect of inflammation on the conducting system of the heart in patients diagnosed with brucellosis. Methods A total of 42 patients diagnosed with brucellosis and 39 age and sex-matched healthy children were enrolled into the study. Pre- and post-treatment electrocardiographic parameters in brucellosis and control group were recorded from an electrocardiogram for each patient. Results The results indicated that the parameters including Pmax, Pdis, QTmax, QTdis, QTcdis, Tp-edis interval and Tp-emax/QTmax and Tp-emax/QTcmax ratios, which are known to be key indicators for the prediction of severe atrial or ventricular arrhythmia and sudden cardiac death and also important parameters used as the indicators for the non-invasive evaluation of the transmural heterogeneity were significantly longer in the study group compared with the control group (p < 0.05). Conclusion In this study, it was determined that the brucella disease had more cardiac involvement than thought, and this was more in the subclinical form of cardiac involvement.

Investigation of the Sensitivity and Specificity of Laboratory Tests Used in Differential Diagnosis of Childhood Brucellosis

“…Fever and monoarthritis, often involving the hip and/or knee joint are common clinical findings in brucellosis; however, no disease-specific pathognomonic signs and symptoms exist [5][6][7]. Although rarely, brucellosis can be associated with a variety of clinical findings; including acute renal failure, endocarditis, splenic abscess, spondylitis, and encephalitis [4,[8][9]. Laboratory tests can often yield normal inflammatory biomarker levels [5].…”

Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis

“…It has been reported that some microorganisms such as Chlamydia pneumoniae and Human cytomegalovirus can cause endothelial dysfunction by affecting the artery walls [ 21 ]. Cetin et al [ 22 ] in their study on pediatric patients with brucella infection reported that there was more heart involvement than expected and that this could be more like subclinical heart involvement. We hypothesized the study to evaluate the role of IMA, gal-3, PON-1, and MPO biomarkers, which are used in the evaluation of the etiopathogenesis of atherosclerosis in patients with acute brucellosis infection, in the pathophysiology of the disease.…”

Relative bradycardia presented as a clinical feature of Brucella melitensis infection: A case report

“…Brucella endocarditis has a predominance of aortic involvement and is prone to left ventricular failure ( 12 ). Cetin M et al demonstrated that the parameters of ECG including Pmax, Pdis, QTmax, QTdis, QTcdis, Tp-edis interval, Tp-emax/QTmax, and Tp-emax/QTcmax ratios were significantly longer among children with brucellosis compared with healthy children, which indicates that the cardiac conduction pathways are affected ( 13 ).…”

“…We have described and considered the potential mechanisms of a case of brucellosis with relative bradycardia. Relative bradycardia could be used as a clinical tool for the diagnosis of various disease etiologies, especially infectious diseases ( 4 , 13 ). Our case demonstrates that relative bradycardia could be associated with B. melitensis infection, an observation that has not been previously reported.…”