The pattern of serum triglyceride fatty acids in Laennec's cirrhosis

Sullivan, James F.; Kelly, Melani R.; Suchy, N.

doi:10.1007/bf02233207

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Differences between the fatty acid composition of the hospital and healthy controls' diets and a reduced intake of fat due to anorexia undoubtedly played a major role in both groups of patients. Furthermore, it has been shown that a reduced proportion of linoleate is found in the plasma in liver disease (Caren and Corbo, 1966;Sullivan, Kelly, and Suchy, 1969), and, since non-specific hepatic dysfunction is a common accompaniment of pyrexial illnesses (Neale, Caughey, Mollin, and Booth, 1966), this could also have been a contributory factor in the 'sick' controls. A comparison of the different categories of malabsorption showed that changes in plasma fatty acid composition were more marked in resection patients than in those with adult coeliac disease or steatorrhoea due to other causes, such as pancreatic dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Fatty acid composition of plasma lipoproteins in control subjects and in patients with malabsorption

Shimoyama¹,

Kikuchi²,

Press³

et al. 1973

Gut

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SUMMARY The fatty acid composition of cholesterol (cholesteryl) ester, triglyceride, and lecithin has been investigated in whole plasma and individual lipoproteins of healthy control subjects, of patients with malabsorption, and also of patients without malabsorption. The results show a decreased proportion of the essential fatty acid linoleic acid in all three lipid classes in both groups of patients as compared with the healthy controls. This abnormality was more marked in the malabsorbers, especially those with steatorrhoea secondary to intestinal resection. Unequivocal biochemical evidence of essential fatty acid deficiency, as indicated by the appearance of 5, 8, 11 eicosatrienoic acid in plasma lecithin, was observed in two patients, both of whom had undergone major intestinal resections. The results suggest that intestinal resection predisposes to the development of essential fatty acid deficiency.The literature on the biochemistry and physiology of essential fatty acids and the syndrome of essential fatty acid deficiency in experimental animals is extensive and has been reviewed relatively recently (Alfin-Slater and Aftergood, 1968). Yet little is known about the occurrence of essential fatty acid deficiency in man, apart from the investigation carried out by Hansen, Wiese, Boelsche, Haggard, Adam, and Davis (1963) who described dermal changes, retardation of growth, and increased caloric requirements in previously healthy infants fed diets low in linoleic acid. Although decreased plasma essential fatty acid levels were reported in children with steatorrhoea due to cystic fibrosis of the pancreas (Kuo and Huang, 1965;Caren and Corbo, 1966) and coeliac disease (Rey, Fr6zal, Polonovski, and Lamy, 1965)

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Section: Discussionmentioning

confidence: 99%

Fatty acid composition of plasma lipoproteins in control subjects and in patients with malabsorption

Shimoyama¹,

Kikuchi²,

Press³

et al. 1973

Gut

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“…However the exact cause of essential fatty acid defi ciency has not been clearly delineated. Since a reduced proportion of linoleate was found in patients with chronic liver disease [7][8][9][10], and multiple sclerosis [20. 21] as well as malnutritional states [22], the malabsorption of dietary linoleate was supposed not to be a considerable etiological factor [7], However, in our results the obvious differences in plasma fatty acid composition between PLE groups A and B suggested that malabsorption of fats due to reduced removal capacity of the lymphatics was an important contributable factor in these changes of fatty acid composi tion.…”

Section: Discussionmentioning

confidence: 99%

“…Abnormal fatty acid composition, espe cially essential fatty acid deficiency in plasma lipids, has been demonstrated in patients with malabsorption [5,6] as well as in pa tients with chronic liver diseases [7][8][9][10]. In this report, analysis of fatty acid composition of plasma lipids in PLE was done to clarify whether essential fatty acid deficiency was found in patients with certain PLE.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Fatty Acid Composition of Plasma Lipids in Patients with Protein-Losing Enteropathy

Miura¹,

Asakura²,

Morishita³

et al. 1982

Digestion

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This study was performed to clarify how disturbance of lipid metabolism occurred in patients with protein-losing enteropathy (PLE) as compared with that of control individuals and patients with malabsorption syndrome. Analysis of plasma lipids at fasting state showed a decreased proportion of essential fatty acid, especially linoleic and arachidonic acid fractions in patients with malabsorption syndrome as well as in patients with PLE group A, which was due to proven disorders of intestinal lymphatics. An increase in percentage of oleic acid fraction and a percentage increase in plasma triglyceride levels after an oral administration of olive oil was depressed in patients with malabsorption syndrome and PLE group A when compared with that of normal subjects. Patients with PLE group B, which was not due to major lymphatic disorders, were similar to normal in these parameters. These abnormalities were found to be marked when remarkable abnormalities of lymphatics were accompanied.

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Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis

1978

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The pattern of serum triglyceride fatty acids in Laennec's cirrhosis

Cited by 4 publications

References 9 publications

Fatty acid composition of plasma lipoproteins in control subjects and in patients with malabsorption

Fatty acid composition of plasma lipoproteins in control subjects and in patients with malabsorption

Abnormal Fatty Acid Composition of Plasma Lipids in Patients with Protein-Losing Enteropathy

Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis

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