Abnormal Fatty Acid Composition of Plasma Lipids in Patients with Protein-Losing Enteropathy

Abstract

This study was performed to clarify how disturbance of lipid metabolism occurred in patients with protein-losing enteropathy (PLE) as compared with that of control individuals and patients with malabsorption syndrome. Analysis of plasma lipids at fasting state showed a decreased proportion of essential fatty acid, especially linoleic and arachidonic acid fractions in patients with malabsorption syndrome as well as in patients with PLE group A, which was due to proven disorders of intestinal lymphatics. An increase in percentage of oleic acid fraction and a percentage increase in plasma triglyceride levels after an oral administration of olive oil was depressed in patients with malabsorption syndrome and PLE group A when compared with that of normal subjects. Patients with PLE group B, which was not due to major lymphatic disorders, were similar to normal in these parameters. These abnormalities were found to be marked when remarkable abnormalities of lymphatics were accompanied.

Serum fatty acid proportions are altered during the year following acute Epstein‐Barr virus infection

“…Although clearly not specific for EBV infection (2)(3)(4)(5)(6)20), an abnormally low ratio of serum linoleic to oleic acid appears after clinical recovery in IM. Abnormal proportions of these major FA appear to be associated with increased clinical symptoms in some post-IM patients and other chronic diseases {2, 3,20).…”

Relationship between shape of peripheral initial lymphatics and efficiency of mechanical stimulation–induced lymph formation

“…Lymphatics are known to relate to several pathophysiological states and diseases, such as edema formation,10 cancer metastasis,39 immune deficiencies,40 collagen diseases,20 and malabsorption syndrome 41. In melanoma and mammary cancer, vital dyes were used to identify the sentinel lymph nodes 36,37.…”