The Pattern of Bacterial Pathogens and Their Antibiotic Susceptibility Profile From Lower Respiratory Tract Specimens in a Rural Tertiary Care Centre

Thomas, Anna; Jayaprakash, Chithra; Amma, Gopala Menon Radhakutty

doi:10.14260/jemds/2016/576

Cited by 7 publications

(15 citation statements)

References 16 publications

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“…This is similar to the findings of Mishra et al (4) and Ramana et al (5) in which the isolation rates were 44% and 39.4% respectively. Similar higher prevalence rates of about 57.4% was shown in a study done by Thomas et al (7) tract infections than female sex. This is similar to the findings of various similar studies done by which were done by Shah, et al (1) ,V.O Lugbue et al (8) , and Akingbade OA (9) .…”

Section: Resultssupporting

confidence: 84%

Study of Gram Negative Bacterial Isolates From Lower Respiratory Tract Infections (LRTI) and Their Antibiogram Pattern in A Tertiary Care Hospital in South India

Elumalai¹

2016

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Section: Resultssupporting

confidence: 84%

Study of Gram Negative Bacterial Isolates From Lower Respiratory Tract Infections (LRTI) and Their Antibiogram Pattern in A Tertiary Care Hospital in South India

Elumalai¹

2016

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“…The most common organism isolated in our study was Pseudomonas aeruginosa followed by Acinetobacter baumanii, E.coli and Klebsiella pneumoniae. This is in concordance with the studies of Thomas et al and Salman et al 18,19 But in some other studies the predominant pathogen was Klebsiella pneumonia. [20][21][22] Against Gram negative bacilli, the most active antibiotic was Colistin (100%) followed by Amikacin, Gentamicin and Piperacillin-tazobactam.…”

Section: Resultssupporting

confidence: 93%

Aerobic bacteriological analysis of bronchoalveolar lavage fluid in patients with pulmonary infection: a tertiary care hospital study

2021

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Background: Respiratory tract infection are an important cause of mortality and morbidity worldwide. The prevalent bacterial agents and their antimicrobial resistance patterns differs, both geographically and over time. Bronchoalveolar lavage has improved sensitivity and specificity of diagnostic techniques in diagnosis of pulmonary infections. The present study aimed to determine the current aerobic bacterial isolates and their sensitivity pattern obtained from the bronchoalveolar lavage (BAL) fluid of patients with pulmonary infection.Methods: BAL samples received from the patients of suspected respiratory tract infections over a period of one year, from June 2018 to May 2019 were processed by standard methods for isolation and identification. The antimicrobial susceptibility was done by the Kirby-Bauer disc diffusion method as per the CLSI guidelines.Results: Out of 322 BAL samples, 84 (26.08%) were found to be culture positive for bacterial isolates. Of those, 44 samples (52.38%) from among males and 40 samples (47.61%) from among females were culture positive .The predominant organism isolated was Pseudomonas aeruginosa 46 (54.76%) followed by Acinetobacter baumanii 13 (15.47%), Escherichia coli 10 (11.90%), Klebsiella pnuemoniae 6 (7.14%) Enterobacter sp 3 (3.57%), Staphylococcus aureus 3 (3.57%), Enterococcus sp 2 (2.38%) and Sphingomonas sp 1 (1.19%). The Gram-negative organisms showed maximum sensitivity to colistin (100%) while as vancomycin and linezolid were the most effective drugs against Gram positive organisms.Conclusions: Bronchoalveolar lavage has improved sensitivity and specificity in diagnosis of pulmonary infections. It is important to have an updated local antibiogram for each hospital and regular surveillance and monitoring of antibiotic resistance and the changing patterns of the bacterial pathogens is a must for better patient management.

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“…1 It includes bronchitis, bronchiectasis, bronchiolitis, emphysema, lung abscess, pleural effusion and pneumonia. 2 Acute lower respiratory tract (ALRI) infections are among the most common infectious diseases affecting humans worldwide causing significant morbidity and mortality for all age groups. 1,3 It is responsible for 4.4% of all hospital admissions and 6% of general practitioner consultations.…”

Section: Introductionmentioning

confidence: 99%

“…5 Each type of LRTI vary in the epidemiology, pathogenesis, clinical presentation, and outcome. 2,5 The major respiratory pathogens are Gram negative bacilli (GNB) like Klebsiella pneumonia (K.pneumoniae), Escherichia coli (Esch.coli), Pseudomonas aeruginosa (P.aeruginosa), Acinetobacter species, other Non-Fermentative Gram-Negative Bacilli (NFGNB) and gram positive organisms like Streptococcus pneumonia (Str.pneumoniae), Staphylococcus aureus (S.aureus) etc. 2 However, results from various surveillance studies show wide variations in the prevalent etiological agents and their antimicrobial resistance patterns, both geographically and over time.…”

Section: Introductionmentioning

confidence: 99%

“…2,5 The major respiratory pathogens are Gram negative bacilli (GNB) like Klebsiella pneumonia (K.pneumoniae), Escherichia coli (Esch.coli), Pseudomonas aeruginosa (P.aeruginosa), Acinetobacter species, other Non-Fermentative Gram-Negative Bacilli (NFGNB) and gram positive organisms like Streptococcus pneumonia (Str.pneumoniae), Staphylococcus aureus (S.aureus) etc. 2 However, results from various surveillance studies show wide variations in the prevalent etiological agents and their antimicrobial resistance patterns, both geographically and over time. The dramatic rise in the antimicrobial resistance among the respiratory pathogens, presumably due to the prophylactic administration of antibacterial therapy even before the availability of the culture reports, is a matter of potential concern worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Bacteriological profile and antibiotic susceptibility patterns of lower respiratory tract infections in a tertiary care hospital, Central Kerala

Ir¹,

Sulekha²

2020

IJMMTD

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Background and Objective: Lower respiratory tract infections (LRTIs) is one of the leading human diseases causing high morbidity and mortality worldwide. The prevalent etiological agents and their antimicrobial resistance patterns differs, both geographically and over time. With emerging resistance of respiratory bacterial pathogens to commonly used antibiotics, it is imperative to study their recent trends for effective management of these cases. Materials and Methods: A retrospective, record based study was conducted on culture and sensitivity reports of lower respiratory samples obtained in the microbiology lab during 1 st January 2015-31st December 2017. The samples were processed by standard methods for isolation and identification followed by antimicrobial sensitivity testing using Kirby Bauer disc diffusion method. Results: 288 (26.34%) of total 1093 samples were positive for bacterial culture. 244 (84.7%) were gram negative bacilli (GNB) and 44 (15.3%) were gram positive cocci. The predominant pathogen isolated was K.pneumoniae (31.1%) followed by P.aeruginosa (30.2%).The overall susceptibility of GNB was highest towards Imipenem followed by Amikacin and Piperacillin tazobactam with resistance rates of 11.5%, 26.2% and 31.6% respectively. Gram positive organisms exhibited highest susceptibility towards Vancomycin and Linezolid. 15.4 % of Staphylococcus aureus were Methicillin resistant (MRSA). Conclusion: Imipenem is the most sensitive antibiotic followed by Amikacin and Piperacillin tazobactam which can be used for empirical therapy for LRTI. The antibiotic therapy should be modified as per the culture and sensitivity report. Regular determinations of the type of bacterial pathogens and updation of antibiogram must be followed in every institution to aid in better patient management by helping the clinician in the judicious use of antibiotics.

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The Pattern of Bacterial Pathogens and Their Antibiotic Susceptibility Profile From Lower Respiratory Tract Specimens in a Rural Tertiary Care Centre

Cited by 7 publications

References 16 publications

Study of Gram Negative Bacterial Isolates From Lower Respiratory Tract Infections (LRTI) and Their Antibiogram Pattern in A Tertiary Care Hospital in South India

Study of Gram Negative Bacterial Isolates From Lower Respiratory Tract Infections (LRTI) and Their Antibiogram Pattern in A Tertiary Care Hospital in South India

Aerobic bacteriological analysis of bronchoalveolar lavage fluid in patients with pulmonary infection: a tertiary care hospital study

Bacteriological profile and antibiotic susceptibility patterns of lower respiratory tract infections in a tertiary care hospital, Central Kerala

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