The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis

Abstract

K E Y W O R D Scardiac dysfunction, liver failure, multi-organ syndrome, portal hypertension

Indocyanine green retention test in cirrhosis and portal hypertension: Accuracy and relation to severity of disease

“…For the estimation of the ICG‐r15, the intercept with the Y‐axis C 0 is defined as Q/PV where Q is the dose . A lower intercept in the patients than in the controls therefore suggests more expanded PV in accordance with the vasodilatation hypothesis …”

“…Patients with cirrhosis exhibit a hyperdynamic circulation with increased cardiac index and PV and low arterial blood pressure and SVR. 35 Interestingly, ICG-r15 and the related parameters correlated with the systemic hemodynamic changes. PV was expanded as compared with reference values.…”

“…To our knowledge the relation between ICG‐r15 and other clinical and hemodynamic variables have not in detail been published before. Patients with cirrhosis exhibit a hyperdynamic circulation with increased cardiac index and PV and low arterial blood pressure and SVR . Interestingly, ICG‐r15 and the related parameters correlated with the systemic hemodynamic changes.…”

“…11 A lower intercept in the patients than in the controls therefore suggests more expanded PV in accordance with the vasodilatation hypothesis. 35 Based on 16 healthy controls, we were able to compile a reference interval ranging from 0 to 13 (%). As it appears from Figure 1, ICG-r15 seems able to identify patients with abnormal excretory hepatic function.…”

Prolonged stay in intensive care unit: Retrospective analysis of predisposing factors and outcome

“…Siroz hastalarında bir diğer kardiyovasküler sorun HD'dir. Kalp hızı, kalp debisi ve sistemik vasküler dirençte (SVD) artış ve arteriyel kan basıncında azalma ile karakterizedir (18)(19)(20). Arteriyel splanknik vazodilatasyon pulmoner hipertansiyon (PH) ve HD oluşumundan sorumlu temel mekanizmalardan biridir.…”