The Pathology of Postcurettage Intrauterine Adhesions

Foix, A; Bruno, Roque O.; Davison, Tomás A.; Lema, Baltasar

doi:10.1097/00006254-196706000-00041

Cited by 12 publications

(13 citation statements)

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“…The functional and basal layers are indistinguishable, with the functional layer replaced by an epithelial monolayer unresponsive to hormonal stimulation and fibrotic synechiae forming across the cavity [63]. …”

Section: Discussionmentioning

confidence: 99%

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies included for a systematic review. Of these, 5 studies were eligible for meta-analysis and 23 for qualitative assessment only. Twenty-eight studies related to the use of IUDs as ancillary treatment following adhesiolysis were identified. Of these studies, 25 studies at least one of the following methods were carried out as ancillary treatment: Foley catheter, hyaluronic acid gel, hormonal therapy, or amnion graft in addition to the IUD. There was one study that used IUD therapy as a single ancillary treatment. In 2 studies, no adjunctive therapy was used after adhesiolysis. There was a wide range of reported menstrual and fertility outcomes which were associated with the use of IUD combined with other ancillary treatments. At present, the IUD is beneficial in patients with IUA, regardless of stage of adhesions. However, IUD needs to be combined with other ancillary treatments to obtain maximal outcomes, in particular in patients with moderate to severe IUA.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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“…They postulate that adhesions limit uterine muscular activity thereby reducing perfusion of sex steroids to the endometrium with atrophy as the consequence (17). Endometrium obtained by curettage during separation of adhesions was found to be secretory in 80%, proliferative in 12%, atrophic in 5%, and hyperplastic in 3% of cases (18). Using full thickness muscle biopsy specimens, Yaffe et al, reported that the uterine wall was composed of 13-20% fibrous tissue in controls, compared with 50-80% in patients with uterine fibrosis, demonstrating a marked increase in the fibrous tissue within the uterine wall (19).…”

Section: Pathologymentioning

confidence: 99%

Intrauterine adhesions

Al-Inany

2001

Acta Obstet Gynecol Scand

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“…The functionalis is the superficial layer, and its growth, deterioration and shedding are hormonally regulated during the menstrual cycle. In severe cases of AS the functionalis becomes atrophic, with fewer glands, and unresponsive to estrogen and progesterone, while the basalis stroma and myometrium become fibrotic and poorly vascularized with the presence of calcification . Such pathological changes may result in hypomenorrhea, amenorrhea, repeated pregnancy loss or infertility.…”

Section: Introductionmentioning

confidence: 99%

“…In severe cases of AS the functionalis becomes atrophic, with fewer glands, and unresponsive to estrogen and progesterone, 1 while the basalis stroma and myometrium become fibrotic and poorly vascularized with the presence of calcification. 2 Such pathological changes may result in hypomenorrhea, amenorrhea, repeated pregnancy loss or infertility. Although adhesions can be removed through hysteroscopy, the predominant treatment option today, they frequently recur.…”

Section: Introductionmentioning

confidence: 99%

Cellular therapies for the endometrium: An update

Queckbörner

Davies

Grothusen

et al. 2019

Acta Obstet Gynecol Scand

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An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis‐promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long‐term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.

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The Pathology of Postcurettage Intrauterine Adhesions

Cited by 12 publications

References 0 publications

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Intrauterine adhesions

Cellular therapies for the endometrium: An update

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