Intrauterine adhesions

Al-Inany, Hesham

doi:10.1034/j.1600-0412.2001.801103.x

Cited by 32 publications

(22 citation statements)

References 41 publications

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“…IUD has been reported as an adjunctive treatment in many studies [7–9, 11–13, 16, 18, 19, 27–43]. Many investigators support the use of IUDs (especially the Lippes loop) for prevention of recurrent IUAs [2, 17, 22–24]. Other studies reported that copper-bearing and Progestasert (Alza Corporation, Palo Alto, CA) IUDs may have a rather small surface area and may not be able to prevent adhesion reformation.…”

Section: Discussionmentioning

confidence: 99%

“…Hysteroscopy represents the gold standard method for the definitive diagnosis and treatment of the IUA. The aim of treatment of IUA is to restore a normal uterine cavity, resume normal menstruation, and improve pregnancy outcomes [17]. The ideal treatment of IUA consists not only of physically removing the adhesion but also of preventing the formation of new ones by the use of other adjunctive measures.…”

Section: Introductionmentioning

confidence: 99%

“…It was speculated that an IUD could help the physiological endometrial regeneration by separating the anterior and posterior uterine walls, although many authors have reported good results [20, 21]. Many investigators support the use of IUDs (especially the Lippes loop) for prevention of recurrent IUAs [2, 17, 22–24]. Other studies reported that copper-bearing and Progestasert (Alza Corporation, Palo Alto, CA) IUDs may have a rather small surface area and may not be able to prevent adhesion reformation.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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The primary purpose of this paper is to assess the efficacy of the use of the intrauterine device (IUD) as an adjunctive treatment modality, for intrauterine adhesions (IUAs). All eligible literatures were identified by electronic databases including PubMed, Scopus, and Web of Science. Additional relevant articles were identified from citations in these publications. There were 28 studies included for a systematic review. Of these, 5 studies were eligible for meta-analysis and 23 for qualitative assessment only. Twenty-eight studies related to the use of IUDs as ancillary treatment following adhesiolysis were identified. Of these studies, 25 studies at least one of the following methods were carried out as ancillary treatment: Foley catheter, hyaluronic acid gel, hormonal therapy, or amnion graft in addition to the IUD. There was one study that used IUD therapy as a single ancillary treatment. In 2 studies, no adjunctive therapy was used after adhesiolysis. There was a wide range of reported menstrual and fertility outcomes which were associated with the use of IUD combined with other ancillary treatments. At present, the IUD is beneficial in patients with IUA, regardless of stage of adhesions. However, IUD needs to be combined with other ancillary treatments to obtain maximal outcomes, in particular in patients with moderate to severe IUA.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Salma

Xue

Sheikh

et al. 2014

BioMed Research International

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“…Traumatic injury or infection of the endometrium (Al-Inany, 2001), pre-pubertal exposure to hormones such as progesterone (Filant et al., 2012), and dysregulation of the uterus (Dahm-Kahler et al., 2016) could cause absence of uterine glandular epithelia in adulthood and even infertility (Kobayashi and Behringer, 2003). Uterine epithelial adenogenesis begins postnatally, involving budding, tubulogenesis, coiling, and branching of luminal epithelia (Gray et al., 2001).…”

Section: Introductionmentioning

confidence: 99%

Reconstructing Lineage Hierarchies of Mouse Uterus Epithelial Development Using Single-Cell Analysis

Wu¹,

Chen²,

et al. 2017

Stem Cell Reports

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SummaryThe endometrial layer comprises luminal and glandular epithelia that both develop from the same simple layer of fetal uterine epithelium. Mechanisms of uterine epithelial progenitor self-renewal and differentiation are unclear. This study aims to systematically analyze the molecular and cellular mechanisms of uterine epithelial development by single-cell analysis. An integrated set of single-cell transcriptomic data of uterine epithelial progenitors and their differentiated progenies is provided. Additionally the unique molecular signatures of these cells, characterized by sequential upregulation of specific epigenetic and metabolic activities, and activation of unique signaling pathways and transcription factors, were also investigated. Finally a unique subpopulation of early progenitor, as well as differentiated luminal and glandular lineages, were identified. A complex cellular hierarchy of uterine epithelial development was thus delineated. Our study therefore systematically decoded molecular markers and a cellular program of uterine epithelial development that sheds light on uterine developmental biology.

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“…Histologically, Asherman’s syndrome is a condition in which the endometrium becomes fibrosed (2), with the endometrial stroma becoming largely replaced by fibrous tissue (3). Under hysteroscopy, patients with Asherman’s syndrome exhibit pale scar tissue distributed in islands among the normal endometrium, with severe IUAs forming thick bands (4). At present, the mechanism underlying intrauterine fibrosis is unclear and there is a lack of effective means for the diagnosis and prevention of the disease worldwide.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-(1–7) and angiotensin II induce the transdifferentiation of human endometrial epithelial cells in vitro

Shan¹,

Zhang²,

Zhao³

et al. 2014

Molecular Medicine Reports

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Intrauterine adhesions (IUA) may be caused by endometrial stromal cell proliferation, increases in myofibroblasts or increases in extracellular matrix secretion. However, the specific mechanisms underlying the development of IUA have yet to be elucidated. The present study identified that angiotensin (Ang) II is capable of promoting endometrial epithelium cell (EEC) proliferation and the transdifferentiation of EECs into myofibroblasts. Furthermore, the present study found that Ang II increased the expression of the myofibroblast specific protein α-smooth muscle actin (α-SMA), decreased the expression and secretion of E-cadherin, and increased the synthesis of collagen type I (Col I) and fibronectin (FN). However, Ang-(1–7) was observed to inhibit Ang II-induced proliferation and transdifferentiation of EECs, decrease the expression of α-SMA, increase the expression of E-cadherin and decrease the synthesis and secretion of Col I and FN. These findings suggest that Ang-(1–7) is capable of inhibiting the Ang II-induced proliferation and transdifferentiation of human EECs and decreases in Col I and FN secretion. The present study may provide insight into the mechanism underlying endometrial fibrosis.

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Intrauterine adhesions

Cited by 32 publications

References 41 publications

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions

Reconstructing Lineage Hierarchies of Mouse Uterus Epithelial Development Using Single-Cell Analysis

Angiotensin-(1–7) and angiotensin II induce the transdifferentiation of human endometrial epithelial cells in vitro

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