The Pathologic Anatomy of Primary Hepatic Tumors

Higgins, George K.

doi:10.1007/978-3-642-48730-9_3

Cited by 8 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Involvement of both liver lobes, an increased weight of the liver, a low grade of differentiation and the multinodular form were all features found to be associated with presence of metastases. We have not, however, been able to confirm the suggestion that HCC patients without liver cirrhosis have higher frequency of metastases ( 12,27) and that the cases with clear cells hardly ever metastasize (12).…”

Section: Discussionmentioning

confidence: 58%

See 1 more Smart Citation

Metastases in Cases with Hepatocellular Carcinoma in Relation to Clinicopathologic Features of the Tumour An autopsy study from a low endemic area

Kaczynski¹,

Hansson

Wallerstedt³

1995

Acta Oncologica

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 58%

“…In one study the multinodular form of HCC was present in approximately two-thirds of all cases (27) but in another one the massive type was the commonest (20). In our study, the massive form was about as common as the multinodular one but was as in other reports (24, 26) the most common type in non-cirrhotic livers.…”

Section: Discussionmentioning

confidence: 99%

Metastases in Cases with Hepatocellular Carcinoma in Relation to Clinicopathologic Features of the Tumour An autopsy study from a low endemic area

Kaczynski¹,

Hansson

Wallerstedt³

1995

Acta Oncologica

View full text Add to dashboard Cite

“…The most common type of HCC is reported to be massive (4) or multinodular (45). In our study, the massive form was about as common as multinodular, but was as in other reports the most common type in noncirrhotic livers (29,46).…”

Section: Pathologic Aspectssupporting

confidence: 38%

Diabetes: One of Few Remarkable Differences in Clinicopathologic Features Between Cirrhotic and Noncirrhotic Swedes With Hepatocellular Carcinoma

2006

View full text Add to dashboard Cite

The prognosis of hepatocellular carcinoma (HCC) is usually very poor, so increased knowledge of clinicopathologic characteristics and etiologic factors may improve the clinical handling. Because HCC in many patients is unrecognized before death, it is of particular interest to study cases from a period with a high autopsy frequency. The records and liver biopsies from all patients with a diagnosis of primary liver cancer in Göteborg, Sweden, during a 22-year period were scrutinized. Only patients with evaluable non-neoplastic liver tissue were included in the final analysis. The majority (95%) of 478 HCC cases were autopsied and cirrhosis of the liver could be established in 71%. At presentation, general paramalignant symptoms such as malaise, weight loss, anorexia, and hepatomegaly (84%) were common irrespective of cirrhosis. Alcoholism and diabetes mellitus were each significantly more common among cirrhotics (29% and 20%, respectively; P < .001), than among noncirrhotics, in which cholelithiasis was more common (54%; P < .001). The correlation between diabetes and cirrhosis was independent of reported alcoholism. In an unselected population in a low HCC incidence area, there are few differences in clinicopathologic features between cirrhotic and noncirrhotic patients. Diabetes mellitus seems to play an etiologic role in HCC in cirrhotics, and cholelithiasis in noncirrhotics.

show abstract

“…Most pathologists agree that 5% of all hepatocellular carcinomas contain cholangiocellular structures (Popper and Schaffner, 1957;Mogena and Ruiz-Funes, 1963;Ohlsson and Norden, 1965;Doll et al, 1966). More than 75% of all primary liver tumors are hepatocellular carcinomas growing macroscopically in the nodular form in two-thirds of all hepatocellular cancers, about 30% consist of the so-called massive form and about 5% of the diffuse type (Higgins, 1970). Unilocular growth with or without intrahepatic metastases is more often observed than multilocular growth.…”

Section: Introductionmentioning

confidence: 99%

Etiology of human liver cancer: Controlled prospective study in liver cirrhosis

Lėhmann

Wegener

1979

Journal of Toxicology and Environmental Health

View full text Add to dashboard Cite

The incidence of primary liver cell carcinoma was investigated in a prospective study over 6 yr and 5 mo in 403 clinically unselected patients derived from a homogeneous population by means of serial determination of alpha 1-fetoprotein (AFP) by radioimmunoassay. The diagnosis of liver cirrhosis was proved in 90% by laparoscopy and/or histology and/or autopsy. The incidence of primary liver cell carcinoma in liver cirrhosis in the clinically studied patients was 4.47%, significantly lower than in the autopsy material (11.03%; p less than or equal to 0.025). In the follow-up study, all patients with increasing AFP concentrations exhibited a primary liver cell carcinoma. A transitory rise of AFP (higher than 50 ng/ml) was observed in 15.1% of patients with liver cirrhosis without primary liver cell cancer. In contrast to the results of animal experiments, this transitory rise of AFP was not followed by malignant transformation of the cirrhotic tissue. Posthepatitic liver cirrhosis was observed in 21.57%, postalcoholic liver cirrhosis in 42.93%, and cryptogenic liver cirrhosis in 27.30%. Liver cirrhosis of other etiology occurred in 8.19%. The incidences of primary liver cell cancer in these 4 groups were 4.94, 4.62, 5.45, and 0%, respectively. These differences are not statistically significant, although in absolute figures postalcoholic liver cirrhosis is the main cause of primary liver cell carcinoma in this sample from West Germany. HBs antigen-positive liver cirrhosis was more often associated with primary liver cell cancer than HBs antigen-negative liver cirrhosis (6.58 versus 3.96%); this difference also is not statistically significant. Observations of larger groups of patients may show a higher risk of developing primary liver cell carcinoma in those with a combination of alcohol abuse and HBs antigenemia and/or acute hepatitis in the history. Patients without these 2 risk factors had an incidence of primary liver cell carcinoma of 2.61%; those with 1 risk factor, 5.77%; and those with both risk factors, 10.71%.

show abstract

The Pathologic Anatomy of Primary Hepatic Tumors

Cited by 8 publications

References 17 publications

Metastases in Cases with Hepatocellular Carcinoma in Relation to Clinicopathologic Features of the Tumour An autopsy study from a low endemic area

Metastases in Cases with Hepatocellular Carcinoma in Relation to Clinicopathologic Features of the Tumour An autopsy study from a low endemic area

Diabetes: One of Few Remarkable Differences in Clinicopathologic Features Between Cirrhotic and Noncirrhotic Swedes With Hepatocellular Carcinoma

Etiology of human liver cancer: Controlled prospective study in liver cirrhosis

Contact Info

Product

Resources

About