The pathogens and curative effects analysis of perianal abscess of infants under 3 months

Abstract

Zhu Y, Xu F. The pathogens and curative effects analysis of perianal abscess of infants under 3 months. Turk J Pediatr 2019; 61: 40-43.In order to guide clinical treatment for perianal abscess of young infants, the characteristics of pathogens and curative effects analysis were conducted. Bacterial culture results, antibiotics susceptibility tests and curative effects of abscess incision were retrospectively analyzed in 66 cases of perianal abscess of infants under 3 months. There were 48 cases of Klebsiella pneumoniae, 7 cases of Staphylococcus, 6 cases of Escherichia coli, 5 cases of Proteus in the pathogen culture results. Klebsiella pneumoniae, the predominant pathogen, was susceptible to most antibiotics, especially to imipenem, cefoperazonesulbactam and amikacin with low drug resistance rates. However, high drug resistance rates were found to ampicillin and nitrofurantion. After abscess incision, the complication rate of anal fistula was 6.6％ in infants under 3 months and 60.3％ in the adult group. There was significant difference P＜0.01. In conclusion, Klebsiella pneumoniae was the most common pathogen in perianal abscess of infants under 3 months and was commonly resistant to ampicillin and nitrofurantion. Since perianal abscess of infants under 3 months is a self-limited disorder, simple surgical intervention and synchronous sensitive antibiotic administration are suggested as the optimal management.

Treatment of Perianal Abscess and Fistula in Infants and Young Children: From Basic Etiology to Clinical Features

“…More than 90% of the patients were men, 5,7,8,[16][17][18][19][20][21][22][23] and most of them were less than 1-year old. 5,6,8,9,20,23 The scope of abscess was generally less than 2 cm, 16 and the lesions were mainly located at 3 and 9 o'clock of lithotomy position 6,7,9,16,20,23 that were obviously laterally distributed.…”

“…4,7,24 The results of pus culture show that the infectious bacteria of perianal abscess and anal fistula include intestinal flora, 4,5,9 skin flora, 4,9 and some mixed flora. 4,16,18 Common bacteria include Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus. Gender differences are also noted.…”

“…Some studies have emphasized the importance of antibiotic use, arguing that antibiotics can shorten the course of disease and reduce the incidence of anal fistula. 8,9,18,22 However, other studies believe that antibiotics have minimal effects on the formation of anal fistula 6,17 and may even aggravate the disease. 23 There are no uniform guidelines for the use of antibiotics in clinical practice.…”

Experimental and theoretical evaluation of two indol-steroid-cyclobuta-imidazole derivatives as antibacterial drugs

“…Some studies indicate that infectious diseases are a serious health problem in the worldwide [1,2]; it is noteworthy that some studies suggest that several bacteria such as Escherichia colli Staphylococcus aureus [3], Streptococcus pneumoniae [4] are causal agents for the development of several infectious diseases. Here it is important to mention that there are some pharmacological tools for the treatment of bacterial diseases [5,6]; unfortunately, since several years ago, bacterial resistance has increased, this phenomenon may be due to some factors, such as; 1) a prolonged antibiotic therapy; 2) uncontrolled antibacterial therapy; or 3) some bacteria have developed several molecular mechanisms as a defense against antibiotics [7]. In the search of new pharmacological tools for treatment of bacterial resistance, have been synthesized some antibacterial drugs to penicillinases inhibition; for example, the preparation of the CP-45,899-drug as an inhibitor of both penicillinases and cephalosporinases bacteria [8].…”

Untitled

“…In relation to different populations of patients, the microorganisms are differentiated in enteric flora, non-enteric flora and skin flora bacteria. The most common pathogen in childhood is Klebsiella Pneumonia, while Escherichia Coli is predominant in adulthood [11]. In our patient, the cultural exam (during all the episodes) was negative, so that we could not take specific treatment.…”