The Pathogenesis of Optic Nerve Drusen

Sacks, Joel G.

doi:10.1001/archopht.1977.04450030067005

Cited by 48 publications

(17 citation statements)

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“…ODD are often associated with vascular anomalies, such as vascular tortuosity, venous dilatation, increased number of vessels on the optic disc, abnormal branching patterns [23,29]. Most vascular anomalies do not lead to vision loss [29].…”

Section: Discussionsupporting

confidence: 43%

“…These vascular abnormalities were present in 81% of our ODD cases, which is a higher rate than those found by other authors: 49% by Mustonen [20], 20% by Rosenberg et al [23] and 21% (24/116) by Borruat and Sanders [30]. The pathogenesis of ODD has been attributed to a congenital abnormality of the optic disc system, which facilitates the transudation of plasma proteins into the extracellular space, thereby favouring its appearance [23,28,29]. In our study, this feature appeared significantly more frequently in the group with hidden ODD compared to papilloedema cases.…”

Section: Discussionsupporting

confidence: 43%

“…Most vascular anomalies do not lead to vision loss [29]. These vascular abnormalities were present in 81% of our ODD cases, which is a higher rate than those found by other authors: 49% by Mustonen [20], 20% by Rosenberg et al [23] and 21% (24/116) by Borruat and Sanders [30].…”

Section: Discussionsupporting

confidence: 42%

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Ophthalmic Features of Optic Disc Drusen

2012

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Purpose: To evaluate the ophthalmoscopic manifestations of patients with visible and hidden optic disc drusen (ODD). Method: We studied 55 patients (100 eyes) with ODD that were confirmed using B-scan ultrasonography and a control group of 60 patients (100 eyes) for differential diagnosis. We analysed the optic nerve features with stereoscopic photography and compared the characteristics between visible and hidden ODD and between hidden ODD and papilloedema. Results: The patients with ODD presented the following ophthalmoscopic features: visible drusen (52%), blurred edges (84%), raised optic disc (74%), absence of optic disc cupping (69%), absence of venous pulse (54%), abnormal vascular branching (81%), presence of cilioretinal vessels (42%), peripapillary atrophy (56%) and haemorrhages (2%). Comparison of the qualitative characteristics of the papillae of the eyes with visible and hidden ODD showed statistically significant differences in all parameters studied, except for morphological alterations (p = 0.851) and haemorrhage (p = 0.954). Comparison of hidden ODD with papilloedema showed statistically significant differences in blurred edges, disc elevation, absence of optic disc cupping, altered colour, anomalous vascular branching and optic disc haemorrhages (p < 0.005). Conclusions: Ophthalmologic features associated with ODD can help us to diagnose their presence and avoid confusing them with papilloedema.

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Section: Discussionsupporting

confidence: 43%

Section: Discussionsupporting

confidence: 43%

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Ophthalmic Features of Optic Disc Drusen

2012

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“…Peripapillary choroidal filling defects on fluorescein angiography have been described in patients with optic disc drusen. 1 Growth factors such as vascular endothelial growth factor (VEGF) may also play a role. Expression of VEGF has been found to be more prominent in the nerve fibre layer near the optic disc in rat retinas.…”

Section: Commentmentioning

confidence: 99%

“…Our case highlights the usefulness of PRP in the treatment of NVD even when the pathogenesis is unclear. 1 This effect is proportional to the amount of laser treatment.…”

Section: Commentmentioning

confidence: 99%