Intrapapillary Refractile Bodies in Optic Nerve Sheath Meningioma

Sibony, Patrick A.; Kennerdell, John S.; Slamovits, Thomas L.; Lessell, Simmons; Krauss, H

doi:10.1001/archopht.1985.01050030079026

Cited by 17 publications

(8 citation statements)

References 19 publications

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“…23 It can be extremely difficult to differentiate ODD from the shiny particles seen in chronic papilledema. 24 The coincidence of ODD and glaucoma may make evaluation of the optic disc and visual field challenging. Although drusen may not block the development of glaucomatous cupping in such cases, the presence of a small, crowded disc may mask glaucomatous cupping.…”

Section: Introductionmentioning

confidence: 99%

Imaging Methods in the Diagnosis of Optic Disc Drusen

Tuğcu¹,

Özdemir²

2016

tjo

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Optic disc drusen (ODD) are benign congenital anomalies of the optic nerve characterized by calcified hyaline bodies. While superficial drusen can be diagnosed easily during fundus examination, detecting buried drusen requires the use of additional imaging methods such as B-scan ultrasonography (USG), fundus fluorescein angiography (FFA), computed tomography (CT) and fundus autofluorescence (FAF). ODD can be detected by USG with the presentation of highly reflective round structures. ODD appear as hyperautofluorescent areas on FAF and bright spots on CT scans. FFA can be helpful in differentiating ODD from true optic disc edema. Optic disc edema shows early hyperfluorescence due to diffuse leakage whereas ODD presents as well-defined hyperfluorescence in the late phase. In recent years, it has been reported that optical coherence tomography (OCT) examination has allowed more detailed evaluation of ODD and yielded useful findings for the differentiation of optic disc edema from ODD. In this review, the role of OCT in the diagnosis of ODD is discussed.

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Section: Introductionmentioning

confidence: 99%

Imaging Methods in the Diagnosis of Optic Disc Drusen

Tuğcu¹,

Özdemir²

2016

tjo

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“…Finally, the presence of nonspecific refractile bodies on the optic disc was noted and was associated with the chronic stage of disc swelling. 12 Computed tomography (CT) revolutionized the diagnosis of ONSM in the 1980s. It easily demonstrates eventual calcification of the ON and hyperostosis associated with ONSM.…”

Section: Pretreatment Aspectsmentioning

confidence: 40%

“…The most common pattern described was diffuse tubular enlargement and, less frequently, globular or fusiform. 2,3,12,19 Tram-tracking, a radiographic sign in which the denser and thickened ONS outlines a central lucency representing the residual ON, is a characteristic finding suggestive of ONSM. It may also, however, be seen in other diffuse sheath thickening such as those found in inflammatory perioptic pseudotumor, ON lymphomas, and optic neuritis.…”

Section: Pretreatment Aspectsmentioning

confidence: 42%

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Primary optic nerve sheath meningioma

Jeremić

Pitz

2007

Cancer

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Biotechnological production of weak organic acids such as succinic acid is most economically advantageous when carried out at low pH. Among naturally occurring microorganisms, several bacterial strains are known to produce considerable amounts of succinic acid under anaerobic conditions but they are inefficient in performing the low‐pH fermentation due to their physiological properties. We have proposed therefore a new strategy for construction of an aerobic eukaryotic producer on the basis of the yeast Yarrowia lipolytica with a deletion in the gene coding one of succinate dehydrogenase subunits. Firstly, an original in vitro mutagenesis‐based approach was proposed to construct strains with Ts mutations in the Y. lipolytica SDH1 gene. These mutants were used to optimize the composition of the media for selection of transformants with the deletion in the Y. lipolytica SDH2 gene. Surprisingly, the defects of each succinate dehydrogenase subunit prevented the growth on glucose but the mutant strains grew on glycerol and produced succinate in the presence of the buffering agent CaCO3. Subsequent selection of the strain with deleted SDH2 gene for increased viability allowed us to obtain a strain capable of accumulating succinate at the level of more than 45 g L−1 in shaking flasks with buffering and more than 17 g L−1 without buffering. The possible effect of the mutations on the utilization of different substrates and perspectives of constructing an industrial producer is discussed. Biotechnol. Bioeng. 2010;107:673–682. © 2010 Wiley Periodicals, Inc.

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“…The observation of refractile bodies preceded or coincided with decline in vision and disappeared as optic atrophy supervened [18].…”

Section: Funduscopic Examinationmentioning

confidence: 43%

Detection and treatment of optic nerve sheath meningioma

Moster

2005

Curr Neurol Neurosci Rep

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Optic nerve sheath meningioma is an uncommon tumor of middle age. Patients most often present with progressive visual loss, mild proptosis, and, occasionally, ocular motility defect. With modern neuroimaging, these tumors are relatively easy to diagnose. However, the computed tomography scan or magnetic resonance imaging scan obtained must be a high-resolution study focused on the optic nerve. Clinical observation may be appropriate for patients with relatively preserved vision. However, when vision deteriorates, fractionated stereotactic radiotherapy is indicated and can often restore or preserve visual function.

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Intrapapillary Refractile Bodies in Optic Nerve Sheath Meningioma

Cited by 17 publications

References 19 publications

Imaging Methods in the Diagnosis of Optic Disc Drusen

Imaging Methods in the Diagnosis of Optic Disc Drusen

Primary optic nerve sheath meningioma

Detection and treatment of optic nerve sheath meningioma

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