The pathogenesis of liver injury in carbon tetrachloride and thioacetamide poisoning

Rees, K. R.; Sinha, K. P.; Spector, W. G.

doi:10.1002/path.1700810113

Cited by 103 publications

(24 citation statements)

References 15 publications

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“…In several tissues, compounds with local anaesthetic activity inhibit to approximately the same extent the net gain of sodium and calcium, and also the net loss of potassium, in response to a variety of excitatory or damaging agents (Gallagher et al, 1956;Rees, Sinha & Spector, 1961;Feinstein, 1963; Judah, Ahmed & McLean, 1964;Feinstein & Paimre, 1969;Chan & Quastel, 1970). The action of indomethacin on cation fluxes seems to differ from that of local anaesthetics in two respects.…”

Section: Discussionmentioning

confidence: 99%

The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea‐pig

Northover

1972

British J Pharmacology

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Summary Isolated tissues of the guinea‐pig were bathed with Krebs solution at 37° C and subjected to 100 ms pulses of electrical stimulation for 30 min at a frequency of 0·1 or 1·0 Hz. The tissues were then dried, ashed, and the ash analysed for calcium, sodium, potassium and magnesium. Gastric smooth muscle, cardiac and skeletal muscles and brain all showed a gain of sodium and calcium and a loss of potassium in response to electrical stimulation, but there was no significant change in the magnesium content of any of these tissues. Indomethacin (0·5 mm) reduced the calcium content of unstimulated gastric smooth muscle and reduced the gain of calcium and sodium in response to electrical stimulation, but slightly increased the net loss of potassium in response to electrical stimulation. Gastric smooth muscle which had gained calcium as a result of electrical stimulation, gradually lost it again when stimulation ceased. Indomethacin (0·5 mm) hastened the net loss of calcium from previously stimulated muscle. Indomethacin (0·5 mm) failed to alter the calcium, sodium, potassium and magnesium contents of unstimulated cardiac muscle, skeletal muscle and brain. In these tissues indomethacin (0·5 mm) also failed to prevent the changes in the content of these minerals which occurred in response to electrical stimulation.

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Section: Discussionmentioning

confidence: 99%

The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea‐pig

Northover

1972

British J Pharmacology

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“…It is well known that a variety of hepatic intracellular enzymes is released into the blood during acute CCI,-poisoning in rats (1)(2)(3)(4). Although the leakage of these enzymes, as suggested by some investigators (4), may be due to the change of permeability of liver cell membranes caused by administration of CC],, experiments which directly prove alter ations in the cell membrane have never been carried out.…”

mentioning

confidence: 99%

STUDIES ON THE FUNCTION OF CELL MEMBRANE 2ndREPORT: ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITE IN THE LIVER CELL MEMBRANE OF RATS FOLLOWING CCl4 ADMINISTRATION

Masuda¹,

Kuchii²,

Yano³

et al. 1973

Japanese Journal of Pharmacology

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Distinctfractional zones of cell membranes in sucrose gradients were ob tainable from homogenates of rat liver up to 6 hr (females) and 12 hr (males) following an i.p. injection of CCI, (0.2 ml/kg body wt.). CCl₄ administration to rats caused a marked elevation of NADH-cytochrome c reductase activity in the liver cell mem brane. There was a remarkable difference between sexes with respect to time-course of the changes of the enzyme activity, viz., a. peak was reached 6 hr after administra tion in female rats and 12 hr in male rats with normal activity at 6 hr. Neither mito chondrial fractions nor microsomal fractions of rat liver displayed any significant alterations in NADH-cytochrome c reductase activity 6 hr after CCl₄ administra tion.

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“…Rees et al (ref 8) have shown that Phenergan pretreatment followed by exposure to carbon tetrachloride reduces Ca -++ imbibition and the efflux of liver enzymes into the blood without reducing liver lipid.…”

Section: Phenergan Pretreatmentmentioning

confidence: 99%

Acute Hepatotoxicity and Enzymatic Response to Hydrazine and 1,1-Dimethylhydrazine in Rats

Reinhardt¹,

Pinkerton²

1965

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The pathogenesis of liver injury in carbon tetrachloride and thioacetamide poisoning

Cited by 103 publications

References 15 publications

The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea‐pig

The effects of indomethacin on calcium, sodium, potassium and magnesium fluxes in various tissues of the guinea‐pig

STUDIES ON THE FUNCTION OF CELL MEMBRANE 2ndREPORT: ELEVATION OF NADH-CYTOCHROME c REDUCTASE ACTIVITE IN THE LIVER CELL MEMBRANE OF RATS FOLLOWING CCl4 ADMINISTRATION

Acute Hepatotoxicity and Enzymatic Response to Hydrazine and 1,1-Dimethylhydrazine in Rats

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