The pathogenesis of bullous skin diseases

Yang, Miao; Wu, Haijing; Zhao, Ming; Chang, Christopher; Lu, Qianjin

doi:10.1016/j.jtauto.2019.100014

Cited by 25 publications

(23 citation statements)

References 170 publications

(171 reference statements)

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“…Subepidermal bullae were seen in 100% cases in the present study, which was similar to the study by Nishioka et al [24]. However, in retrospective cases, 50% cases of BP showed intraepidermal bullae.…”

Section: Discussionsupporting

confidence: 91%

Utility of Direct Immunofluorescence in Cutaneous Autoimmune Bullous Disorders

Brar¹,

Sharma²,

Nauhria³

et al. 2021

Cureus

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BackgroundAutoimmune bullous disorders (AIBD) are a heterogeneous group of disorders with substantial clinical overlap associated with blistering of skin or mucosa. AimsThe present study aimed to study the histopathological spectrum and evaluate the utility of direct immunofluorescence (DIF) on snap-frozen and paraffin-embedded sections in resolving the differential diagnosis of AIBD and connective tissue disorders of the skin. We also compared the efficacy of DIF on paraffin versus the snap-frozen sections in diagnosing AIBD. MethodsThe present study was conducted for three years (2017-2019) and included 27 biopsies. We also included a retrospective analysis that included 25 biopsies collected over three years (2014)(2015)(2016)(2017). Histopathological examination and DIF were conducted on all samples. ResultsPemphigus vulgaris was the most common autoimmune cutaneous disorder constituting 37% (n = 10) in prospective and 36% (n = 9) in the retrospective study. DIF showed a specificity of 81.25% in our prospective study. While on the paraffin-embedded sections, it showed a specificity of 66.6% in our retrospective study. In the prospective study, DIF on paraffin-embedded sections had a positivity rate of 43.75% as compared to 81.25% in DIF done on snap-frozen sections. ConclusionDIF is a sensitive tool for the diagnosis as well as distinguishing immune-mediated bullous disorders from other lesions primarily when performed on snap-frozen sections. The diagnostic yield is enhanced by DIF in cases that pose a diagnostic dilemma both clinically and histologically. The final diagnosis depends on all clinical, histopathological and immunofluorescence findings.

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Section: Discussionsupporting

confidence: 91%

Utility of Direct Immunofluorescence in Cutaneous Autoimmune Bullous Disorders

Brar¹,

Sharma²,

Nauhria³

et al. 2021

Cureus

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“…In the former, the removal of the offending drug leads to the resolution of BP but not in the later. The offending drugs can be topical or systemic in nature . There is also a known association between BP and neurological conditions such as stroke, dementia, and Parkinson's disease, although the pathophysiology for this relationship is still unknown.…”

Section: Discussionmentioning

confidence: 99%

Bullous pemphigoid‐like skin rash associated with Rivaroxaban use in a very elderly patient with multimorbidity and chronic kidney disease: A case report

Chohan

Balasubramanian

2020

Clinical Case Reports

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“…BP is a complex multifactorial disorder that is common in elderly patients (5). In the present review, the disease mechanisms and related triggers and comorbidities of BP have been explored, with the aim of highlighting conditions that are typically found in elderly patients.…”

Section: Introductionmentioning

confidence: 99%