Bullous pemphigoid: An immune disorder related to aging (Review)

Deotto, Maria Ludovica; Spiller, Alice; Sernicola, Alvise; Alaibac, Mauro

doi:10.3892/etm.2021.10972

Cited by 25 publications

(29 citation statements)

References 97 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Skin aging is a slow and complex process subjected to intrinsic alterations at the cellular, molecular and genetic levels and by exposure to extrinsic factors (43). Aging affects all layers of the skin; in particular, the underlying epidermis and dermis undergo numerous cellular and molecular changes due to aging (44).…”

Section: Discussionmentioning

confidence: 99%

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

Feng

Jiang

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

The skin is the largest outermost organ of the human body. It is vulnerable to various damages, such as ionizing radiation. Exploration of proliferation, senescence and radiosensitivity of skin cells contributes to the development of medical and cosmetic countermeasures against skin aging and toward injury protection. Human antigen R (HuR) is one of the most widely studied RNA-binding proteins and serves an important role in stabilization of mRNA and regulation of the expression of the target genes. To investigate the role of HuR in modulating proliferation, senescence and radiosensitivity of skin cells, the present study performed an in vitro study using lentivirus-mediated overexpression or silencing of HuR in human keratinocyte HaCaT cells and human skin fibroblast WS1 cells. The results indicated that overexpression of HuR promoted proliferation, whereas downregulation of HuR inhibited proliferation of HaCaT and WS1 cells. Overexpression of HuR reduced apoptosis and senescence in skin cells. RNA-Seq of skin cells with HuR overexpression or knockdown identified 77 mRNAs positively or negatively correlated with HuR expression levels. In addition, silencing of HuR induced a significant increase in radiogenic reactive oxygen species after irradiation. Overexpression of HuR increased radiotolerance of HaCaT and WS1 cells. RNA immunoprecipitation coupled with RNA-Seq identified 14 mRNAs interacting with HuR upon radiation exposure. Overall, the findings of the present study illustrated the key role of HuR in modulating proliferation, senescence and radiosensitivity of skin cells providing a new therapeutic strategy for cosmetic treatments and to combat skin injury.

show abstract

Section: Discussionmentioning

confidence: 99%

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

Feng

Jiang

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Moreover, the possible release of self-antigens by damaged keratinocytes that contribute to the production of antibodies against neo-antigens might be enhanced by skin barrier impairment [ 297 ]. Accordingly, Bullous Pemphigoid, a subepidermal autoimmune blistering disease, is common in elderly patients [ 300 , 301 ]. Low antioxidant capacity/redox disequilibrium has been proven in Bullous Pemphigoid as well as in other non-age-related autoimmune skin blistering diseases [ 302 ].…”

Section: Contribution Of Ros In Common Age-related Skin Diseasesmentioning

confidence: 99%

Focus on the Contribution of Oxidative Stress in Skin Aging

et al. 2022

View full text Add to dashboard Cite

Skin aging is one of the most evident signs of human aging. Modification of the skin during the life span is characterized by fine lines and wrinkling, loss of elasticity and volume, laxity, rough-textured appearance, and pallor. In contrast, photoaged skin is associated with uneven pigmentation (age spot) and is markedly wrinkled. At the cellular and molecular level, it consists of multiple interconnected processes based on biochemical reactions, genetic programs, and occurrence of external stimulation. The principal cellular perturbation in the skin driving senescence is the alteration of oxidative balance. In chronological aging, reactive oxygen species (ROS) are produced mainly through cellular oxidative metabolism during adenosine triphosphate (ATP) generation from glucose and mitochondrial dysfunction, whereas in extrinsic aging, loss of redox equilibrium is caused by environmental factors, such as ultraviolet radiation, pollution, cigarette smoking, and inadequate nutrition. During the aging process, oxidative stress is attributed to both augmented ROS production and reduced levels of enzymatic and non-enzymatic protectors. Apart from the evident appearance of structural change, throughout aging, the skin gradually loses its natural functional characteristics and regenerative potential. With aging, the skin immune system also undergoes functional senescence manifested as a reduced ability to counteract infections and augmented frequency of autoimmune and neoplastic diseases. This review proposes an update on the role of oxidative stress in the appearance of the clinical manifestation of skin aging, as well as of the molecular mechanisms that underline this natural phenomenon sometimes accelerated by external factors.

show abstract

“…IgE antibodies against BP230, and to a lesser extent BP180, have also been found in pruritic elderly patients [ 83 ]. It is important to also note that age-related senescence of the skin, which includes impairments in physical and immunological barrier function, is thought to be a significant factor in the susceptibility of elderly patients to the development of BP in general [ 84 ].…”

Section: Bp230 Autoantibodies In Pruritus Of the Elderlymentioning

confidence: 99%

Deciphering the Contribution of BP230 Autoantibodies in Bullous Pemphigoid

2022

View full text Add to dashboard Cite

Bullous pemphigoid (BP) is a subepidermal autoimmune blistering disease predominantly affecting elderly patients and carries significant morbidity and mortality. Patients typically suffer from severe itch with eczematous lesions, urticarial plaques, and/or tense blisters. BP is characterized by the presence of circulating autoantibodies against two components of the hemidesmosome, BP180 and BP230. The transmembrane BP180, also known as type XVII collagen or BPAG2, represents the primary pathogenic autoantigen in BP, whereas the intracellular BP230 autoantigen is thought to play a minor role in disease pathogenesis. Although experimental data exist suggesting that anti-BP230 antibodies are secondarily formed following initial tissue damage mediated by antibodies targeting extracellular antigenic regions of BP180, there is emerging evidence that anti-BP230 IgG autoantibodies alone directly contribute to tissue damage. It has been further claimed that a subset of patients has a milder variant of BP driven solely by anti-BP230 autoantibodies. Furthermore, the presence of anti-BP230 autoantibodies might correlate with distinct clinical features. This review summarizes the current understanding of the role of BP230 and anti-BP230 antibodies in BP pathogenesis.

show abstract

Bullous pemphigoid: An immune disorder related to aging (Review)

Cited by 25 publications

References 97 publications

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

The role of human antigen R (HuR) in modulating proliferation, senescence and radiosensitivity of skin cells

Focus on the Contribution of Oxidative Stress in Skin Aging

Deciphering the Contribution of BP230 Autoantibodies in Bullous Pemphigoid

Contact Info

Product

Resources

About