The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes.

Wands, Jack R.; Mann, Edward O.; Alpert, Elliot; Isselbacher, Kurt J.

doi:10.1172/jci108022

Cited by 173 publications

(52 citation statements)

References 24 publications

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“…7) ng/ml) and IgM (mean 23,319 ng/ml) were produced in these allogeneic cultures (Fig. 9) (24)(25)(26)(27)(28). However, the specificity of the tests for detecting anti-HBs in the presence of high levels of HBsAg has not been well documented.…”

Section: Co-culture Experimentsmentioning

confidence: 95%

See 1 more Smart Citation

Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.

Dusheiko¹,

Hoofnagle²,

Cooksley³

et al. 1983

J. Clin. Invest.

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A B S T R A C T It hasIn order to identify the mechanisms for the lack of detectable anti-HBs synthesis by chronic HBsAg carrier lymphocytes, co-culture experiments were performed using T and B lymphocyte fractions that had been purified by affinity chromatography. B lymphocytes from carriers co-cultured with allogeneic irradiated ("helper") T lymphocytes from controls synthesized normal amounts of IgG, IgM, and anti-HBc Dr. Dusheiko was the recipient of a South African Research Council Overseas Scholarship. His present address is

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Section: Co-culture Experimentsmentioning

confidence: 95%

“…Two other patients had minor, nonspecific changes in liver biopsy histology without evidence of hepatitis. 28 patients had symptoms, but they were usually mild; the most common symptom was fatigability. Most patients were otherwise healthy.…”

mentioning

confidence: 99%

Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.

Dusheiko¹,

Hoofnagle²,

Cooksley³

et al. 1983

J. Clin. Invest.

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“…Other reviews do not mention arthritis as a feature of echovirus illness (1)(2)(3)(4)(12)(13)(14). Viral synovitis is generally considered to occur from either direct synovial involvement' or circulating and local immune complexes (17), as proposed for hepatitis B (18). Mitigating against direct viral synovial involvement, but by no means conclusively refuting this possibility, virus was not isolated from the synovial biopsy or synovial fluid specimens in this case, The serum total hemolytic complement was elevated and the synovial fluid complement seemingly low; however, without knowledge of the synovial fluid total protein, the synovial fluid complement can not be interpreted as decreased (i.e., cannot be interpreted as suggesting an immune complex pathogenesis).…”

Section: Discussionmentioning

confidence: 99%

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

1978

Arthritis & Rheumatism

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A patient with fever, myalgias, and acute polyarthritis in whom echovirus 9 was isolated from throat and rectal swab specimens is described. All symptoms resolved spontaneously over a one week period except for the arthritis which required three months for complete recovery. A mildly inflammatory synovial fluid and histologic picture were observed. Attempts to isolate the virus from synovial fluid and synovium during acute illness were unsuccessful.Although echoviruses are recognized producers of a wide spectrum of human illness, arthritis is generally not considered part of this spectrum (1-3), or at most is an exceedingly rare occurrence in echovirus infections (43). Only one weakly documented case of acute arthritis attributed to echovirus is reported in the English language literature (4). A second case documented by viral isolation is reported here and presents the hitherto undescribed synovial fluid and synovial histologic findings. CASE REPORTA 35-year-old female bookkeeper was admitted to the Hospital of the University of Pennsylvania on July 18, 1970 with complaints of fever and myalgias. On July 15, the patient awoke with a painful right shoulder. By evening, chills, fever, and myalgias had developed coincident with marked neck stiffness and pain in both shoulders and the right arm. The shoulders, elbows, ankles, and right metatarsophalangeal (MTP) joints became painful with conspicuous swelling of the knees, ankles, and right MTP joints. The patient was prescribed phenylbutazone by her local physician but noted no symptomatic relief. She denied cough, coryza, sore throat, conjunctivitis, alopecia, mouth ulcers, jaundice, pruritis, Raynaud's phenomenon, nausea, vomiting, abdominal discomfort, or vaginal discharge. The day prior to admission, she noted three small evanescent erythematous skin lesions on her arms. There was no past or family history of rheumatic fever or joint disease. The patient denied recent immunizations or exposure to jaundiced or otherwise ill persons.On admission, she was alert but in obvious distress from painful joints and was unable to walk. Her oral temperature was 39°C (102°F). N o skin eruptions or adenopathy were noted. There was conspicious nuchal rigidity with painful limitation of neck motion. The mandible was tender with painful temporomandibular joint limitation of motion. Diminished right shoulder range of motion without effusion was present. Erythema and tenderness over the left ulnar styloid without wrist effusion were noted. Bilateral non-erythematous relatively non-tender knee effusions were evident, The medial aspect of the left ankle was erythematous, swollen, and tender. The right ankle was tender and swollen with limitation of motion, but was not erythematous. The right first, second, and third MTP joints were hot, erythematous, swollen, and exquisitely tender. No tenosynovitis was present.Laboratory studies revealed a hematocrit of 37 and a leukocyte count of 13,600/mmS with 81% neutrophils and 19%

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“…Conversion of the C3-proactivator (C3PA) to its activated form (C3A) was determined by immunoelectrophoresis as previously described (Wands et al, 1975). Fresh normal human serum (NHS) and zymozan-activated NHS served respectively as negative and positive controls.…”

Section: Methodsmentioning

confidence: 99%

Screening Tests in Chemical Carcinogenesis

Fox¹

1976

Br J Cancer

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Summary.-Serum complement levels were assayed in 26 patients with disseminated cancer, who received immunotherapy with infusion of C. parvum. Complement activation, indicated by the consumption of C3 or C4 or both, was found in 46°' of the patients.Serum samples showed direct correlation between decreased C3 and conversion of C3 proactivator, whereas such conversion did not occur when C4 alone was decreased. It is concluded that the bypass (properdin) pathway was activated in patients in whom C3 consumption was detected, while the classical (Cl) pathway was activated in the patients with C4 consumption unaccompanied by C3 decrease. Direct correlation was observed between delayed cutaneous hypersensitivity reactions to recall antigens and the incidence of C. parvum-associated complement activation.

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The pathogenesis of arthritis associated with acute hepatitis-B surface antigen-positive hepatitis. Complement activation and characterization of circulating immune complexes.

Abstract: A B S T R A C

Cited by 173 publications

References 24 publications

Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.

Synthesis of antibodies to hepatitis B virus by cultured lymphocytes from chronic hepatitis B surface antigen carriers.

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

Screening Tests in Chemical Carcinogenesis

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