The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis

Chang, Christopher; Greenspan, Adam; Gershwin, M. Eric

doi:10.1016/j.jaut.2020.102460

Cited by 143 publications

(122 citation statements)

References 64 publications

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“…SONFH is a progressive bone disorder caused by excessively administrating glucocorticoids and resulted in vascular damage, mechanism stress damage, intraosseous pressure increasing, adipocyte dysfunction, apoptosis, and coagulation dysfunction 5 . In our study, we rst identi ed the biological function of SONFH, which includes programmed necrotic cell death, intracellular lipid transport, necrotic cell death, lymph vessel morphogenesis, hydrogen peroxide catabolic process, and lymph vessel development.…”

Section: Discussionmentioning

confidence: 99%

“…Osteonecrosis usually occurs in the anterolateral femoral head, although it may also affect the femoral condyles, humeral heads, proximal tibia, vertebrae, and small bones of the hand and foot 3 . The previous studies have demonstrated that steroid is an established risk factor of osteonecrosis of the femoral head (ONFH) [4][5][6] . Moreover, numerous researches have proved that the mechanism of steroid-induced osteonecrosis of the femoral head (SONFH) including oxidative stress 7 , osteoclasts activation 8 , bone formation and resorption 9 , et al SONFH most have been diagnosed by magnetic resonance imaging (MRI) 5 .…”

Section: Introductionmentioning

confidence: 99%

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Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Cheng¹,

Nie²,

Peng³

2020

Preprint

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BACKGROUNDː Steroid-induced osteonecrosis of the femoral head (SONFH) is a progressive bone disorder and its characterized by femoral head collapse and hip joint dysfunction and the biomarkers of SONFH remain unclear. The purposes of this study are to identify the significant biological function and pathway involved in SONFH, and further to search the underlying mechanism of this pathway in SONFH. METHODSː The GSE123568 dataset obtained from the Gene Expression Omnibus (GEO) database and normalized using Robust Multiarray Averaging (RMA) methods. And the Gene set enrichment analysis (GSEA), Ingenuity pathway analysis (IPA), VarElect online tool, MalaCards database, miRWalk online tool, DIANA too, and Cytoscape were integrated for bioinformatics analyses.RESULTSː 6 biological processes and 4 KEGG pathways were enriched by GSEA, and 68 candidate genes were involved in these pathways. Besides, the canonical pathway and molecule function analysis by IPA, the results revealed that 10 canonical pathways and 12 candidate genes were identified, and 20 modules and 101 candidate genes were enriched by molecule function analysis. The above candidate genes were combined and filtered using the VarElect online tool. The filtered candidate genes were overlapped with another cluster of candidate genes from the MalaCards database to identify hub genes ACP5, TNF, MMP8. Based on the hub genes, the miRNAs were screened and overlapped to predict the lncRNAs. Total 7 miRNAs of ACP5, TNF, MMP8 were targeted 956 candidate lncRNAs.CONCLUSIONSː In summary, this study identified the hub candidate genes and pathways associated with SONFH progress, and constructed the ceRNA network based on the hub candidate genes. Our findings might provide the potential biomarkers of SONFH diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Cheng¹,

Nie²,

Peng³

2020

Preprint

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“…Xin-Yuan Wang 1,* Lin-Lin Zhang 2,* Chang Jiang 1 Bing-Xuan Hua 1 Zong-Fei Ji 3 Wen-Shuai Fan 1 Lin-Jing Gong 4 Liang Zhu 5 Xiang-Dong Wang 2 Zuo-Qin Yan 1…”

Section: E T H I C S a P P R O Va Lmentioning

confidence: 99%

Altered lipidomic profiles in patients with and without osteonecrosis of the femoral head after 1‐month glucocorticoid treatment

Wang

Zhang

Hua

et al. 2021

Clinical & Translational Med

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“…Glucocorticoids induce osteoporosis and osteonecrosis in humans [1][2][3][4][5][6][7]. In-depth study of glucocorticoid-induced osteoporosis has revealed that the reduction in bone mass incompletely explains the increased fracture risk [8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Bone Strength/Bone Mass Discrepancy in Glucocorticoid‐Treated Adult Mice

et al. 2020

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The pathogenesis, diagnosis and clinical manifestations of steroid-induced osteonecrosis

Cited by 143 publications

References 64 publications

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Identification of Candidate Genes Associated with Steroid-Induced Osteonecrosis of The Femoral Head by Bioinformatics Based on GEO Database

Altered lipidomic profiles in patients with and without osteonecrosis of the femoral head after 1‐month glucocorticoid treatment

Bone Strength/Bone Mass Discrepancy in Glucocorticoid‐Treated Adult Mice

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