The Pathogenesis and Pathology of Infection in Calves with a Strain of Bovine Adenovirus Type 3

Darbyshire, J.H.; Jennings, A.R.; Dawson, Patrick; Lamont, P. H.; Omar, Azizan

doi:10.1016/s0034-5288(18)34714-3

Cited by 54 publications

(24 citation statements)

References 12 publications

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“…These results showed that BAV-3 was able to replicate in guinea pigs and could cause consolidation in the lungs of infected guinea pigs that resembled the gross pneumonic lesions of calves experimentally infected with BAV-3. However, petechial hemorrhage, which was observed in the lungs of guinea pigs experimentally infected with HLJ0955 was not observed in calves experimentally infected with BAV-3 [7,10,13,18]. This suggests that the pathogenesis of BAV-3 is slightly different in guinea pigs and calves, but quite different in guinea pigs and cotton rats.…”

Section: Discussionmentioning

confidence: 90%

“…Similarly, calves experimentally infected with the Japanese BAV-3 by endobronchial inoculation also had elevated rectal temperatures and consolidation in the lungs [18]. Earlier reports also showed that intranasal inoculation with BAV-3 caused a few clinical signs of respiratory disease, and areas of consolidation or atelectasis were evident to varying degrees in the lungs of infected calves from the 4th to 7th day of infection at necropsy [6,7,10,13]. These results showed that BAV-3 was able to replicate in guinea pigs and could cause consolidation in the lungs of infected guinea pigs that resembled the gross pneumonic lesions of calves experimentally infected with BAV-3.…”

Section: Discussionmentioning

confidence: 92%

“…BAV-3 was first isolated in bovine kidney cultures from a swab taken from the eye of an apparently healthy cow in 1965 in Britain [5]. In further pathogenesis studies in newborn calves, the virus was shown to cause a few clinical signs, and apparent gross and histological lesions were observed in the lungs of infected calves [6,7]. Those results indicated that BAV-3 was pathogenic to newborn calves and could cause respiratory diseases.…”

Section: Introductionmentioning

confidence: 98%

“…To date, some studies on the pathogenesis of BAV-3 infection in calves have been conducted [7,10,13,18]. Only limited study on the pathogenesis of BAV-3 infection in cotton rats was conducted, and intranasal inoculation of cotton rats with BAV-3 caused histological lesions in the lungs [17].…”

Section: Introductionmentioning

confidence: 99%

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Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs

et al. 2014

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Bovine adenovirus type 3 (BAV-3) is considered one of the most important respiratory tract agents of cattle and is widespread among cattle around the world. A BAV-3 strain was isolated from a bovine nasal swab for the first time in China in 2009 and named HLJ0955. Subsequently, BAV-3 has frequently been isolated from calves with respiratory diseases in China. To date, only limited study on the pathogenesis of BAV-3 infection in cotton rats has been conducted, and the pathogenesis of BAV-3 infection in guinea pigs has not been reported. Therefore, sixteen albino guinea pigs were inoculated intranasally with HLJ0955. All of the infected guinea pigs had apparently elevated rectal temperatures (39.2 °C-39.9 °C) at 2-7 days post-inoculation (PI). Consolidation and petechial hemorrhage were also observed in guinea pigs experimentally infected with HLJ0955. Viral replication was detectable by virus isolation and titration and by immunohistochemistry in the lungs of guinea pigs as early as 24 h PI. Viral DNA was detectable in the lungs of infected guinea pigs during 11 days of observation by real-time PCR. Virus-neutralizing antibodies against BAV-3 were detectable from 11 days PI and reached a peak titer at 15 days PI. Histopathological changes mainly occurred in the lungs of infected guinea pigs and were characterized by thickening of alveolar septa, mononuclear cell infiltration, hemorrhage and alveolar epithelial necrosis. These results indicate that HLJ0955 can replicate in the lungs of guinea pigs and cause fever and gross and histological lesions. The guinea pig infection model of BAV-3 would serve as a useful system for monitoring the infection process and pathogenesis of the Chinese BAV-3 strain HLJ0955, as well as immune responses to BAV-3 vaccines.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs

et al. 2014

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“…Bovine adenoviruses have been isolated from cattle with a wide variety of diseases involving primarily respiratory and enteric tissues as well as from apparently healthy cattle (3,12,13,14). Calf inocu]ation studies with different isolates and serotypes have produced responses varying from no elinicM reactions to severe reactions (5,7,12,13,14). The path-ologieM changes observed were confined primarily to the respiratory system.…”

Section: Introductionmentioning

confidence: 99%