A bovine adenovirus type 3: Isolation, characterization, and experimental infection in calves

Lehmkuhl, Howard D.; Smith, M. H.; Dierks, R. E.

doi:10.1007/bf01320564

Cited by 33 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, EB inoculation, which does not mimic the natural route of exposure of the agent, would seem to be an efficient method for studying the pathogenesis of BAV-3 and other respiratory infectious agents. 19,20 The lesions of adenoviral respiratory diseases in naturally and experimentally infected cattle 5,6,10,12,[14][15][16] and in dogs, goats, and other species 2,3,8,11,13,17 have included severe necrotizing bronchitis with necrosis of epithelial cells and intranuclear inclusion bodies. In the present study, the pneumonic lesions in calves infected with BAV-3 included moderate to severe necrotizing bronchitis, bronchiolitis, and alveolitis, characterized by the infiltration of inflammatory cells and proliferation of type 2 epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Immunohistopathology of Calf Pneumonia Induced by Endobronchial Inoculation with Bovine Adenovirus 3

et al. 2002

View full text Add to dashboard Cite

Abstract. Three 1-week-old and three 3-month-old Holstein calves that had received colostrum were inoculated endobronchially with bovine adenovirus 3 (BAV-3). The gross and histologic lesions in these six infected calves were localized mainly in the right caudal lobe of the lung and were closely associated with the site of the deposition of the inoculum. The pneumonic lesions were severe necrotizing bronchitis, bronchiolitis, and alveolitis, accompanied by infiltration of inflammatory cells and proliferation of type 2 pneumocytes. Intranuclear inclusion bodies, BAV-3 antigen, and virus particles were detected in the degenerated epithelial cells in the 1-week-old but not the 3-month-old calves. After infection, the total cell count in the bronchoalveolar lavage (BAL) fluid cells was increased. The results of BAV-3 isolation from BAL fluid were correlated with the detection of intranuclear inclusion bodies in the desquamated epithelial cells in the BAL fluid cells from the right caudal lobe but not in cells from the left caudal lobe. CD8ϩ T lymphocytes in the pneumonic lesion were found only in the 3-month-old infected calves. The difference in the immunopathologic reactions between the 1-week-old and the 3-month-old infected calves may be attributed to differences in immune system development.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunohistopathology of Calf Pneumonia Induced by Endobronchial Inoculation with Bovine Adenovirus 3

et al. 2002

View full text Add to dashboard Cite

show abstract

“…PAdV also has been isolated from pigs with encephalitis and pneumoenteritis (78,85). Some BAdV, such as BAdV-3, have been shown to replicate in cattle and produce mild or no clinical signs, but several other serotypes have been linked to keratoconjunctivitis, acute febrile disease, pneumonenteritis, and acute and fatal enteric diseases in calves (78,96,105).…”

Section: Adenovirusesmentioning

confidence: 99%

Enteric Viruses of Humans and Animals in Aquatic Environments: Health Risks, Detection, and Potential Water Quality Assessment Tools

Fong

Lipp

2005

Microbiol Mol Biol Rev

627

450

View full text Add to dashboard Cite

Waterborne enteric viruses threaten both human and animal health. These pathogens are host specific and cause a wide range of diseases and symptoms in humans or other animals. While considerable research has documented the risk of enteric viruses to human health from contact with contaminated water, the current bacterial indicator-based methods for evaluation of water quality are often ineffectual proxies for pathogenic viruses. Additionally, relatively little work has specifically investigated the risk of waterborne viruses to animal health, and this risk currently is not addressed by routine water quality assessments. Nonetheless, because of their host specificity, enteric viruses can fulfill a unique role both for assessing health risks and as measures of contamination source in a watershed, yet the use of animal, as well as human, host-specific viruses in determining sources of fecal pollution has received little attention. With improved molecular detection assays, viruses from key host groups can be targeted directly using PCR amplification or hybridization with a high level of sensitivity and specificity. A multispecies viral analysis would provide needed information for controlling pollution by source, determining human health risks based on assessments of human virus loading and exposure, and determining potential risks to production animal health and could indicate the potential for the presence of other zoonotic pathogens. While there is a need to better understand the prevalence and environmental distribution of nonhuman enteric viruses, the development of improved methods for specific and sensitive detection will facilitate the use of these microbes for library-independent source tracking and water quality assessment tools

show abstract

“…To date, some studies on the pathogenesis of BAV-3 infection in calves have been conducted [7,10,13,18]. Only limited study on the pathogenesis of BAV-3 infection in cotton rats was conducted, and intranasal inoculation of cotton rats with BAV-3 caused histological lesions in the lungs [17].…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs

et al. 2014

View full text Add to dashboard Cite

Bovine adenovirus type 3 (BAV-3) is considered one of the most important respiratory tract agents of cattle and is widespread among cattle around the world. A BAV-3 strain was isolated from a bovine nasal swab for the first time in China in 2009 and named HLJ0955. Subsequently, BAV-3 has frequently been isolated from calves with respiratory diseases in China. To date, only limited study on the pathogenesis of BAV-3 infection in cotton rats has been conducted, and the pathogenesis of BAV-3 infection in guinea pigs has not been reported. Therefore, sixteen albino guinea pigs were inoculated intranasally with HLJ0955. All of the infected guinea pigs had apparently elevated rectal temperatures (39.2 °C-39.9 °C) at 2-7 days post-inoculation (PI). Consolidation and petechial hemorrhage were also observed in guinea pigs experimentally infected with HLJ0955. Viral replication was detectable by virus isolation and titration and by immunohistochemistry in the lungs of guinea pigs as early as 24 h PI. Viral DNA was detectable in the lungs of infected guinea pigs during 11 days of observation by real-time PCR. Virus-neutralizing antibodies against BAV-3 were detectable from 11 days PI and reached a peak titer at 15 days PI. Histopathological changes mainly occurred in the lungs of infected guinea pigs and were characterized by thickening of alveolar septa, mononuclear cell infiltration, hemorrhage and alveolar epithelial necrosis. These results indicate that HLJ0955 can replicate in the lungs of guinea pigs and cause fever and gross and histological lesions. The guinea pig infection model of BAV-3 would serve as a useful system for monitoring the infection process and pathogenesis of the Chinese BAV-3 strain HLJ0955, as well as immune responses to BAV-3 vaccines.

show abstract

A bovine adenovirus type 3: Isolation, characterization, and experimental infection in calves

Cited by 33 publications

References 14 publications

Immunohistopathology of Calf Pneumonia Induced by Endobronchial Inoculation with Bovine Adenovirus 3

Immunohistopathology of Calf Pneumonia Induced by Endobronchial Inoculation with Bovine Adenovirus 3

Enteric Viruses of Humans and Animals in Aquatic Environments: Health Risks, Detection, and Potential Water Quality Assessment Tools

Pathogenesis of a Chinese strain of bovine adenovirus type 3 infection in albino guinea pigs

Contact Info

Product

Resources

About