The past, present and future of ligament regenerative engineering

Mengsteab, Paulos Y.; Nair, Lakshmi S.; Laurencin, Cato T.

doi:10.2217/rme-2016-0125

Cited by 30 publications

(30 citation statements)

References 54 publications

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“…All relevant manuscripts were accessed and articles that combined tissue engineering approaches for both tendons and ligaments were included. Articles that discussed different tissue engineering approaches of the tendon/ligament to bone interface were also excluded due to the broadness of the topic and the important number of review articles on the subject [8,[22][23][24].…”

Section: Materials and Methodologymentioning

confidence: 99%

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Alshomer

Chaves

Kalaskar

2018

Journal of Materials

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Introduction. Tendons are specialised, heterogeneous connective tissues, which represent a significant healthcare challenge after injury. Primary surgical repair is the gold standard modality of care; however, it is highly dependent on the extent of injuries. Tissue engineering represents an alternative solution for good tissue integration and regeneration. In this review, we look at the advanced biomaterial composites employed to improve cellular growth while providing appropriate mechanical properties for tendon and ligament repair. Methodology. Comprehensive literature searches focused on advanced composite biomaterials for tendon and ligament tissue engineering. Studies were categorised depending on the application. Results. In the literature, a range of natural and/or synthetic materials have been combined to produce composite scaffolds tendon and ligament tissue engineering. In vitro and in vivo assessment demonstrate promising cellular integration with sufficient mechanical strength. The biological properties were improved with the addition of growth factors within the composite materials. Most in vivo studies were completed in smallscale animal models. Conclusions. Advanced composite materials represent a promising solution to the challenges associated with tendon and ligament tissue engineering. Nevertheless, these approaches still demonstrate limitations, including the necessity of larger-scale animal models to ease future clinical translation and comprehensive assessment of tissue response after implantation.

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Section: Materials and Methodologymentioning

confidence: 99%

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Alshomer

Chaves

Kalaskar

2018

Journal of Materials

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“…Silk fibers lose their tensile strength in 1 year and undergo complete proteolytic degradation within 2 years in vivo [7]. This allows a gradual transfer of mechanical load from the scaffold to the neoligament [57].…”

Section: Silkmentioning

confidence: 99%

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

et al. 2020

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Ligaments and tendons are fibrous tissues with poor vascularity and limited regeneration capacity. Currently, a ligament/tendon injury often require a surgical procedure using auto-or allografts that present some limitations. These inadequacies combined with the significant economic and health impact have prompted the development of tissue engineering approaches. Several natural and synthetic biodegradable polymers as well as composites, blends and hybrids based on such materials have been used to produce tendon and ligament scaffolds. Given the complex structure of native tissues, the production of fiber-based scaffolds has been the preferred option for tendon/ligament tissue engineering. Electrospinning and several textile methods such as twisting, braiding and knitting have been used to produce these scaffolds. This review focuses on the developments achieved in the preparation of tendon/ ligament scaffolds based on different biodegradable polymers. Several examples are overviewed and their processing methodologies, as well as their biological and mechanical performances, are discussed. Fig. 20 a 3D view of the theoretical designed PLA screw-like scaffold structure. b The prepared PLA screw-like scaffold. c The SEM image of the PLA scaffold surface with well-defined orthogonal structure (Reprinted with permission from [114])

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“…Scaffold can provide homing signals to MSC and help the attachment, proliferation process and cell differentiation. This reduced scaffold is associated with decreased levels of inflammatory cytokines needed for healing responses such as fibrinogen, PDGF, TGF-β and FGF [4,8,15].…”

Section: Effectiveness Of Mesenchymal Stem Cells Therapy In Acl Imentioning

confidence: 99%

Stem Cell Therapy in Anterior Cruciate Ligament (ACL) injury

Rustiasari¹,

Zein²

2018

Proceedings of the 2nd Yogyakarta International Seminar on Health, Physical Education, and Sport Science (YISHPESS 2018) and 1s

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The incidence of musculoskeletal injuries are the most common injuries that occur in exercise practice. These injuries can involve many different tissues such as muscles, tendons, ligaments, meniscus, bone or cartilage. Anterior cruciate ligament (ACL) tears are the most common athletic injury that occurs in the world, occupies up to 50% of the incidence of knee injury. Optimal healing process has become a consideration in choosing the most suitable management especially for professional athletes as well as their teams. Many recent studies in the management of musculoskeletal injuries is currently been developed from basic molecular level, experimental studies until clinical application in patients. The application of stem cells therapy becomes a great interest in ACL injury. The ability of stem cells to undergo multilineage differentiation into a variety of cell types is expected to have great potential in the process of repair and regeneration of musculoskeletal injury. The purpose of this review is to summarize the latest developments in the application of stem cell therapy and its safety and effectiveness in ACL injury.

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The past, present and future of ligament regenerative engineering

Cited by 30 publications

References 54 publications

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Advances in Tendon and Ligament Tissue Engineering: Materials Perspective

Biodegradable polymer nanocomposites for ligament/tendon tissue engineering

Stem Cell Therapy in Anterior Cruciate Ligament (ACL) injury

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