The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells

Pink, Ryan C.; Samuel, Priya; Massa, Davide; Caley, Daniel P.; Brooks, Susan A.; Carter, David Raul Francisco

doi:10.1016/j.ygyno.2014.12.042

Cited by 179 publications

(130 citation statements)

References 45 publications

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“…Low expression of miR-718 in exosomes in HCC has been reported as a risk factor for tumor recurrence after liver transplantation [104]. Moreover, the downregulation of exosomal miR-92a in HCC is associated with cancer progression and a high risk of recurrence [105], and the overexpression of exosomal miR-21-3p indicates cisplatin resistance in ovarian cancer [106]. Additionally, higher expression of migration inhibitory factor (MIF) in exosomes in pancreatic ductal adenocarcinoma (PDAC) primes the liver for metastasis and may represent a prognostic marker for the development of PDAC liver metastasis [107].…”

Section: Diagnosis and Prognosis Assessmentmentioning

confidence: 99%

Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

Zhang¹,

Xia

et al. 2017

Cell Physiol Biochem

209

150

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Precision medicine and personalized medicine are based on the development of biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry information on tumor development and progression. Compared with traditional ‘solid biopsy’, which cannot always be performed to determine tumor dynamics, liquid biopsy has notable advantages in that it is a noninvasive modality that can provide diagnostic and prognostic information prior to treatment, during treatment and during progression. In this review, we describe the source, characteristics, technology for detection and current situation of circulating tumor cells, circulating free DNA and exosomes used for diagnosis, recurrence monitoring, prognosis assessment and medication planning.

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Section: Diagnosis and Prognosis Assessmentmentioning

confidence: 99%

Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

Zhang¹,

Xia

et al. 2017

Cell Physiol Biochem

209

150

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“…The MIR21 gene is located at17q23.2, a region frequently amplified in several tumors (84, 85). Its overexpression has been observed in most cancer types and modulates the resistance toward apoptosis-inducing drugs (86–91). Down-regulation of miR-21 sensitizes cancer cells in vitro to different chemotherapeutics, including cisplatin, etoposide and doxorubicin (92–94).…”

Section: A Network Analysis: the Most Central Ncrnas In Chemoresistancementioning

confidence: 99%

The Network of Non-coding RNAs in Cancer Drug Resistance

et al. 2018

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Non-coding RNAs (ncRNAs) have been implicated in most cellular functions. The disruption of their function through somatic mutations, genomic imprinting, transcriptional and post-transcriptional regulation, plays an ever-increasing role in cancer development. ncRNAs, including notorious microRNAs, have been thus proposed to function as tumor suppressors or oncogenes, often in a context-dependent fashion. In parallel, ncRNAs with altered expression in cancer have been reported to exert a key role in determining drug sensitivity or restoring drug responsiveness in resistant cells. Acquisition of resistance to anti-cancer drugs is a major hindrance to effective chemotherapy and is one of the most important causes of relapse and mortality in cancer patients. For these reasons, non-coding RNAs have become recent focuses as prognostic agents and modifiers of chemo-sensitivity. This review starts with a brief outline of the role of most studied non-coding RNAs in cancer and then highlights the modulation of cancer drug resistance via known ncRNAs based mechanisms. We identified from literature 388 ncRNA-drugs interactions and analyzed them using an unsupervised approach. Essentially, we performed a network analysis of the non-coding RNAs with direct relations with cancer drugs. Within such a machine-learning framework we detected the most representative ncRNAs-drug associations and groups. We finally discussed the higher integration of the drug-ncRNA clusters with the goal of disentangling effectors from downstream effects and further clarify the involvement of ncRNAs in the cellular mechanisms underlying resistance to cancer treatments.

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“…During miRNA biogenesis, the pre-miRNA hairpin generates a double-stranded miRNA (miRNA duplex), which is made up of a guide strand (also called miRNA or miRNA-5p) and a passenger strand (called miRNA-3p and known previously as miRNA*) that is often considered to be degraded, and therefore non-functional. However, several studies have shown that a passenger strand miRNA can act as a mature miRNA [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Differential regulation of miR-146a/FAS and miR-21/FASLG axes in autoimmune lymphoproliferative syndrome due to FAS mutation (ALPS-FAS)

Marega

Teocchi

Vilela

2016

Clinical and Experimental Immunology

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1These authors contributed equally to the study. SummaryMost cases of autoimmune lymphoproliferative syndrome (ALPS) have an inherited genetic defect involving apoptosis-related genes of the FAS pathway. MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs playing a role in the control of gene expression. This is the first report on miRNAs in ALPS patients. We studied a mother and son carrying the same FAS cell surface death receptor (FAS) mutation, but with only the son manifesting the signs and symptoms of ALPS-FAS. The aim was to analyse, by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), the peripheral blood mononuclear cells (PBMC) relative expression of miR-146a and miR-21, including their passenger strands and respective targets (FAS and FASLG). In comparison with healthy matched control individuals, miR-21-3p was over-expressed significantly (P 5 0Á0313) in the son, with no significant change in the expression of miR-146a, miR-146a-3p and miR-21. In contrast, the mother had a slight under-expression of the miR-146a pair and miR-21-3p (P 5 0Á0625). Regarding the miRNA targets, FAS was up-regulated markedly for the mother (P 5 0Á0078), but down-regulated for the son (P 5 0Á0625), while FASLG did not have any significant alteration. Taken together, our finding clearly suggests a role of the miR-146a/FAS axis in ALPS-FAS variable expressivity in which FAS haploinsufficiency seems to be compensated only in the mother who had the miR-146a pair down-regulated. As only the son had the major clinical manifestations of ALPS-FAS, miR-21-3p should be investigated as playing a critical role in ALPS physiopathology, including the development of lymphoma.

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The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells

Cited by 179 publications

References 45 publications

Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

The Network of Non-coding RNAs in Cancer Drug Resistance

Differential regulation of miR-146a/FAS and miR-21/FASLG axes in autoimmune lymphoproliferative syndrome due to FAS mutation (ALPS-FAS)

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