The part played by the renal nerves in the production of water diuresis in the hypophysectomized and decerebrate dog

Bayliss, L. E.; Brown, Andrea N.

doi:10.1113/jphysiol.1940.sp003844

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…These results show that though vasoconstriction occurred in the innervated kidney when ether or cyclopropane were inhaled, a sustained vasoconstriction was not observed after denervation. This is consonant with the finding of Bayliss & Brown (1940) that, in decerebrate dogs with denervated kidneys, inhaled ether did not affect the creatinine clearance. We conclude that the renal vasoconstriction brought about by inhalation of ether and cyclopropane is neurogemc.…”

Section: Resultssupporting

confidence: 88%

Renal vasoconstriction produced by ether and cyclopropane anaesthesia

Miles¹,

Wardener²

1952

The Journal of Physiology

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In man and animals, ether and cyclopropane anaesthesia bring about substantial renal vasoconstriction. Opinion differs as to whether its cause is nervous, humoral or the local action of the anaesthetic. The following investigation attempts to decide this point.The method used was identical in principle with that employed by Richards & Plant (1922). Single kidneys of anaesthetized dogs were perfused at a controlled rate and the changes in perfusion pressure induced by ether or cyclopropane were recorded. METHODSSixteen 5-16 kg mongrel dogs were anaesthetized with pentobarbitone sodium (23-38 mg/kg) and a constant level of anaesthesia maintained by continuous intravenous infusion (0.04 mg/kg/min).After intubation, 100% oxygen was given in closed circuit with a carbon dioxide absorber. One or other renal artery was cannulated through a flank incision, care being taken as far as was possible to avoid damage to the renal nerves which could be seen along the surface of the artery. The blood for perfusion was led into the flow-meter and pump from a cannula in the left carotid artery. Heparin (30-40 mg) was given before cannulation.When the kidney was denervated, all structures seen approaching the hilus, other than the artery, vein and ureter, were severed. Completeness of denervation was confirmed by the absence of prompt renal vasoconstriction during a rapid bleed of 100 ml. of blood from the carotid artery into the reservoir, the blood being immediately retransfused. In two dogs, so that denervation should be unequivocal, the perfused kidney was removed from the body and placed in saline at a thermostatically controlled temperature of 38.5°C. In these experiments on the isolated kidney a cannula was placed in the renal vein, and the blood returned from the kidney to the general circulation via another cannula in the left jugular vein. Plastic Portex tubing was used throughout and the circuit was charged with 140 ml. of a 6 % solution in normal saline of Dextran (Intradex, Crooke's Laboratories).The flow-meter has been described previously (de Wardener & Miles, 1952). The pump, however, was a new adaptation in which the motor, piston and platform of the standard Dale Schuster pump were used (Fig. 1). At each stroke its piston was made to compress a short length of rubber tubing, thus forcing a quantity of blood past an outlet valve in the direction of the kidney; an inlet valve prevented flow in the reverse direction. Rubber flap valves were used.

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Section: Resultssupporting

confidence: 88%

Renal vasoconstriction produced by ether and cyclopropane anaesthesia

Miles¹,

Wardener²

1952

The Journal of Physiology

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“…He found that inhibition of a water diuresis by various anaesthetics did not prevent the typical fall in chloride output normally accompanying the diuresis. Later, Bayliss & Brown (1940), working on hypophysectomized decerebrate dogs, were led to the tentative conclusion that some structure in the tuber cinereum was concerned with the excretion of chloride.…”

Section: Discussionmentioning

confidence: 99%

The effect of ethyl alcohol and some other diuretics on chloride excretion in man

Eggleton¹,

Smith²

1946

The Journal of Physiology

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Evidence as to the nature of the diuresis following ingestion of ethyl alcohol (ethanol) suggests that it is similar to the diuresis following ingestion of water. In view of the lack of absolute proof of their identity, however, a further comparison of the two has been made in respect of certain properties by which a water diuresis can be differentiated from other types of diuresis. One such property is the response of the kidney in respect of excretion of chloride; an increased rate of urine flow is in general associated with an increased output of chloride, but, in a water diuresis, the great increase in rate of flow is accompanied by a diminished chloride output (Eggleton, 1943). The results of a series of class experiments on the effect of exercise on renal function, when different diuretics were used to promote urine flow, suggested that alcohol and water had the same effect in diminishing excretion of chloride (Eggleton, 1945), whereas tea increased it. The matter has now been investigated more fully and under more standardized conditions, without the additional effects of exercise. METHODSThe general procedure was the same as that used in previous investigations. Each experiment was performed at least 5 hr. after the last meal, usually in the early afternoon; if in the morning, breakfast was omitted. Usually a glass of water was taken 2-3 hr. before the experiment began, to ensure a reasonable state of body hydration. In the experiments now reported, all substances under investigation were taken by mouth, and at least one urine sample was collected before their ingestion.In a few of the earlier experiments, urinary chloride was determined by the electrometric titration method (Eggleton, Eggleton & Hamilton, 1937); in the remainder, a direct titration method, using tartrazine as indicator, was used with complete satisfaction. This method is simple and was foun& to be unexpectedly accurate over a wide range of chloride concentration in urine. The urine was delivered slowly from a 10 c.c. micro-burette into a boiling tube containing 2 c.c. 29-2

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Physiology of the kidney

Wesson¹

1965

Handbuch Der Urologie / Encyclopedia of Urology / Encyclopédie D’urologie

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The part played by the renal nerves in the production of water diuresis in the hypophysectomized and decerebrate dog

Cited by 8 publications

References 9 publications

Renal vasoconstriction produced by ether and cyclopropane anaesthesia

Renal vasoconstriction produced by ether and cyclopropane anaesthesia

The effect of ethyl alcohol and some other diuretics on chloride excretion in man

Physiology of the kidney

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