Globoidal indexing cam mechanism is the spatial indexing mechanism of high speed, high precision and widely used in modern machine and automatic production line.But the working profile of the globoidal indexing cam mechanism is not fair for the space curved surface and it is difficult to model. The traditional design method requires a great deal of calculation, and the design process is complexed, we have to repeat the entire design process when changing any parameters, lead to low design efficiency and poor universality. To solve above disadvantages, this paper used the space meshing principle and space coordinate transformation method, based on 3 d modeling software Pro/ENGINEER, using vc + + and Pro/toolkit for secondary development, realize the parametric modelling of globoidal indexing cam mechanism, and the simulation and analysis of the generated cam mechanism.