The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic

Neel, Brian A.; Sargis, Robert M.

doi:10.2337/db11-0153

Cited by 221 publications

(139 citation statements)

References 64 publications

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“…3. Diabetes has been seen to be strongly correlated with glyphosate usage on core crops in the United States in previous work [41] (more generally, a strong correlation is seen between the emergence of the diabetes epidemic in the USA and the increased production of all synthetic chemicals [42]). …”

Section: Resultsmentioning

confidence: 99%

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

Seneff¹,

Causton²,

Nigh³

et al. 2017

JBPC

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Section: Resultsmentioning

confidence: 99%

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

Seneff¹,

Causton²,

Nigh³

et al. 2017

JBPC

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“…The understanding of Sirt1 regulation of PXR function [14] in xenobiotics metabolism is now required with important involvement of PXR in HDL cholesterol metabolism [124] [125]. Furthermore, the involvement of PXR in the diabetes has increased with the involvement of various PXR agonists in glucose and lipid dysregulation [126] [127]. In obesity, the brain disorders that involve the SCN regulation of the sleep-wake cycle have possible connections to Sirt1dysregulation and effects on PXR and its role on energy and xenobiotic metabolism.…”

Section: Endocrine Disruptors As Risk Factors For Obesity and Chronicmentioning

confidence: 99%

Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries

Martins¹

2014

OJEMD

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The susceptibility of individuals to obesity has been reported in many developed countries with predisposition of humans to obesity associated with high calorie diets and unhealthy lifestyles. Obesity may closely be involved in cell suicide in various organ diseases with the importance of accelerated aging that requires early intervention with drug therapy to prevent diseases such as non alcoholic fatty liver disease (NAFLD) that has increased in children and reached to approx. 40% of the global population. Obesity is induced by various diets and lifestyle factors such as stress, anxiety and depression which are important to consider with the global increase in obesity and are possibly linked to the rise in individuals with brain disorders that involve neurodegeneration. Xenobiotics such as the endocrine disruptor chemicals that have increased in the environment in various developed countries lead to various chronic endocrine diseases as populations divert towards unhealthy diets and lifestyles with induction of NAFLD and obesity. The amount and nature of food intake that improves and increases liver lipid and xenobiotic metabolism in obese individuals have become important to decrease the risk for increased adiposity in man. High fibre or protein diets that contain leucine may improve liver glucose, lipid and xenobiotic metabolism and require further investigation with xenobiotics such as endocrine disruptors involved in appetite dysregulation and metabolic disorders in developed countries. The use of anti-obese drugs that reduce food intake and improve hypercholesterolemia and cardiovascular disease has been assessed in obesity with drug therapy closely involved either in the prevention or induction of NAFLD and obesity in man.

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“…34 It has been suggested that together with other endocrine disrupting chemicals (EDCs), BPA constitutes a risk factor for type 2 diabetes and other metabolic disorders. [35][36][37] Recent work shows the association between increasing urinary BPA levels and diabetes mellitus. A 12.8% of diabetic patients show high BPA levels in urine samples (4.20 ng/ml or 18 nM).…”

Section: Bisphenol a As An Endocrine Disruptormentioning

confidence: 99%

“…34 Moreover an association between urinary levels of BPA, obesity and insulin resistance in middle-aged and elderly Chinese adults has been recently described. 37 The range of BPA levels found in humans is from 0.7 to 20 nM. 37,38 To support the evidence that BPA may be a risk for the development of diabetes it is critical to study its effect on human tissues involved in glucose and lipid metabolism, including the endocrine pancreas which is key in glucose homeostasis.…”

Section: Bisphenol a As An Endocrine Disruptormentioning

confidence: 99%

“…37 The range of BPA levels found in humans is from 0.7 to 20 nM. 37,38 To support the evidence that BPA may be a risk for the development of diabetes it is critical to study its effect on human tissues involved in glucose and lipid metabolism, including the endocrine pancreas which is key in glucose homeostasis. The islet of Langerhans is the physiological unit of the endocrine pancreas; it is a group of 1500-3000 cells of five different types and the most abundant are bcells.…”

Section: Bisphenol a As An Endocrine Disruptormentioning

confidence: 99%

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Use of polycarbonate plastic products and human health

Srivastava

Godara

2013

Int J Basic Clin Pharmacol

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As plastic and plastic products are being used in day to day at the cost of environment pollution, the human and wild life health and has become a global concern. Researchers found link between abnormal liver enzymes in the people and Bisphenol-A (BPA). Changes in insulin resistance, reproduction system, cardiovascular and brain function are also reported. BPA is used in the production of epoxy resins, polycarbonate resins, and polyester resins. BPA can leach out of certain plastic products including variety of modern goods, reusable food storage containers, eyeglass lenses, white dental fillings, sealants, medical equipments etc. In the body, BPA behaves as an estrogen receptor agonist and mimics estrogen hormone. Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. Children and unborn and new born babies are at high risk of unwanted effects of BPA. Children suffer from chronic exposure to bisphenol A with manifestation of gastrointestinal problems, adrenal stress, immune dysfunction, toxic over load and neurological disorders. Some study in Japan has observed that more BPA can leach from polycarbonate products that have been scratched or is more than 4 years old or used bottles that have been subjected to bottle brushing or dishwashing and sterilization. People exposed to higher levels of BPA due to use of plastic food and beverages containers are more likely to develop cardiovascular diseases, diabetes and metabolic disorder. Recent studies have suggested that BPA exposure may have a role in the development of weight gain, insulin resistance, pancreatic endocrine dysfunction, thyroid hormone disruption, and several other mechanisms involved in the development of diabetes. Urinary BPA levels are found to be associated with diabetes mellitus independent of traditional diabetes risk factors. There is a concern of exposure of BPA to pregnant women that can affect the development of offspring in the womb. It is considered that women may be placing their fetuses at the risk by having dental sealants applied during pregnancy. Public should be educated about the use of plastic and plastic products which can prove to be hazardous and risk factor to many health problems of human and wild life. [Int J Basic Clin Pharmacol 2013; 2(1.000): 12-17

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The Paradox of Progress: Environmental Disruption of Metabolism and the Diabetes Epidemic

Cited by 221 publications

References 64 publications

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

Can glyphosate’s disruption of the gut microbiome and induction of sulfate deficiency explain the epidemic in gout and associated diseases in the industrialized world?

Induction of NAFLD with Increased Risk of Obesity and Chronic Diseases in Developed Countries

Use of polycarbonate plastic products and human health

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