The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery Disease

Margaglione, Maurizio; Cappucci, Giuseppe; Colaizzo, Donatella; Giuliani, Nicola; Vecchione, Gennaro; Pennelli, Orazio; Minno, Giovanni Di

doi:10.1161/01.atv.18.2.152

Cited by 123 publications

(80 citation statements)

References 36 publications

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“…6 -8 We have previously found that the 4G/4G gene variant of the plasminogen activator inhibitor-1 (PAI-1) gene is associated with a history of coronary artery disease in a first-degree relative. 9 Raised concentrations of C-reactive protein (CRP) have been found to predict recurrent ischemia, myocardial infarction, and sudden death among patients with multiple risk factors for coronary artery disease and angina pectoris. 10 -12 In the ECAT study, raised levels of CRP at baseline consistently predicted myocardial infarction or sudden death over the 3 years of follow-up.…”

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confidence: 99%

C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives

Margaglione

Cappucci

Colaizzo

et al. 2000

ATVB

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Abstract-The relevance of elevated levels of C-reactive protein (CRP) in cardiovascular disease is gaining increasing recognition. A family history of coronary artery disease is a major determinant of coronary artery disease in the offspring. In a cohort of 1048 individuals without clinical evidence of atherosclerosis, we investigated the relationships between CRP levels and a family history of myocardial infarction. We measured CRP, fibrinogen, plasminogen activator inhibitor-1, total cholesterol, triglycerides, and some genetic polymorphisms: plasminogen activator inhibitor-1 (4G/5G), fibrinogen (B␤-chain G3 A Ϫ455 ), and angiotensin-converting enzyme insertion/deletion (I/D). Clinical data were collected by a World Health Organization-modified questionnaire for cardiovascular disease. When compared with subjects without first-degree relatives who had suffered a myocardial infarction (nϭ867), subjects with such first-degree relatives (nϭ181) were older (Pϭ0.001), more often hypertensive (PϽ0.001), and homozygous for the 4G allele (4G/4G) of the plasminogen activator inhibitor-1 gene (Pϭ0.003). In addition, they had a higher body mass index (Pϭ0.036), raised plasma fibrinogen (PϽ0.007) and total cholesterol (PϽ0.001) concentrations, and CRP levels Ͼ0.33 mg/L (Pϭ0.005). In a multiple logistic regression analysis, age (odds ratio [OR] 1.03, 95% confidence interval [95% CI] 1.01 to 1.05), total cholesterol (OR 1.35, 95% CI 1.11 to 1.65), plasminogen activator inhibitor-1 4G/4G (OR 1.72, 95% CI 1.20 to 2.45), and CRP levels Ͼ0.33 mg/L (OR 1.75, 95% CI 1.05 to 2.91) were all independently associated with a positive family history of myocardial infarction. We therefore conclude that raised levels of CRP independently identify the offspring of patients with a myocardial infarction. (Arterioscler Thromb Vasc

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confidence: 99%

C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives

Margaglione

Cappucci

Colaizzo

et al. 2000

ATVB

Self Cite

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“…In relation to the rest of polymorphisms, Margaglione et al [28] in a cohort of 1,179 healthy employees found that the 4G/4G carriers exhibited a more frequent family history of CAD, supporting the hypothesis that the 4G variant was a transmissible coronary risk factor. However, Panahloo et al [29] found no evidence that subjects with the 4G/4G polymorphism had higher PAI-1 levels on admission or 6 months after MI.…”

Section: Gpiiia No-a1a1 (A1a2+a2a2) Gpiiia A1a1mentioning

confidence: 88%

Prognostic value of ACE I/D, AT1R A1166C, PAI-I 4G/5G and GPIIIa a1/a2 polymorphisms in myocardial infarction

et al. 2014

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“…U estalost PAI-1 4G/5G genske varijante varira zavisno od etni ke pripadnosti (17)(18)(19)(20)(21)(22). Frekvenca ove genske varijante odre ivana je za veliki broj populacija, ali do sada nema objavljenih podataka za srpsku populaciju.…”

Section: Uvodunclassified

“…The prevalence of PAI-1 4G/5G gene variant varies depending on ethnicity (17)(18)(19)(20)(21)(22). The frequency of this gene variant was determined for a number of populations, but there is no data observed for Serbian population.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of PAI-1 4G/5G gene variant in Serbian population

Đorđević¹,

Gvozdenov²,

Pruner³

et al. 2013

Med gl Ins stit Zlatibor

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SažetakUvod: Inhibitor aktivatora plazminogena 1 (PAI-1) ima zna ajnu ulogu u procesu inhibicije  brinolize i normalne hemostaze.Prisustvo PAI-1 4G/4G genotipa uzrokuje pove anje ekspresije PAI-1. Povišen nivo PAI-1 u krvi povezan je sa brojnim bolestima kao što su tromboza, moždani udar, infarkt miokarda, spontani poba aji, preeklampsija, insulinska rezistencija, dijabetes tipa 2, rak dojke i astma. U okviru ove studije odre ivana je u estalost PAI-1 4G/5G genske varijante kod zdravih ispitanika u srpskoj populaciji.Metode: Studija je obuhvatala grupu od 210 zdravih ispitanika (105 žena i 105 muškaraca). Prisustvo PAI-1 4G/5G genske varijante detektovano je PCR-RFLP metodom.Rezultati: U estalost PAI-1 4G/4G genotipa iznosila je 34,76% i bila je pove ana u odnosu na PAI-1 5G/5G genotip (19,05%), dok je najzastupljeniji genotip bio PAI-1 4G/5G (46,19%). U estalost 4G alela bila je viša (0,58) u odnosu na 5G alel (0,42).Zaklju ci: U estalost PAI-1 4G/5G genske varijante u srpskoj populaciji sli na je sa okolnim populacijama. Rezultati ove studije su zna ajni, jer predstavljaju prve podatke za srpsku populaciju što e omogu iti dalja istraživanja o ulozi PAI-1 4G/5G genske varijante u patogenezi brojnih bolesti. AbstractIntroduction: Plasminogen activator inhibitor 1 (PAI-1) has a major role in inhibition of  brinolysis and normal haemostasis.

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The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery Disease

Cited by 123 publications

References 36 publications

C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives

C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives

Prognostic value of ACE I/D, AT1R A1166C, PAI-I 4G/5G and GPIIIa a1/a2 polymorphisms in myocardial infarction

The prevalence of PAI-1 4G/5G gene variant in Serbian population

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