C-Reactive Protein in Offspring Is Associated With the Occurrence of Myocardial Infarction in First-Degree Relatives

Abstract

Abstract-The relevance of elevated levels of C-reactive protein (CRP) in cardiovascular disease is gaining increasing recognition. A family history of coronary artery disease is a major determinant of coronary artery disease in the offspring. In a cohort of 1048 individuals without clinical evidence of atherosclerosis, we investigated the relationships between CRP levels and a family history of myocardial infarction. We measured CRP, fibrinogen, plasminogen activator inhibitor-1, total cholesterol, triglycerides, and some genetic polymorphisms: plasminogen activator inhibitor-1 (4G/5G), fibrinogen (B␤-chain G3 A Ϫ455 ), and angiotensin-converting enzyme insertion/deletion (I/D). Clinical data were collected by a World Health Organization-modified questionnaire for cardiovascular disease. When compared with subjects without first-degree relatives who had suffered a myocardial infarction (nϭ867), subjects with such first-degree relatives (nϭ181) were older (Pϭ0.001), more often hypertensive (PϽ0.001), and homozygous for the 4G allele (4G/4G) of the plasminogen activator inhibitor-1 gene (Pϭ0.003). In addition, they had a higher body mass index (Pϭ0.036), raised plasma fibrinogen (PϽ0.007) and total cholesterol (PϽ0.001) concentrations, and CRP levels Ͼ0.33 mg/L (Pϭ0.005). In a multiple logistic regression analysis, age (odds ratio [OR] 1.03, 95% confidence interval [95% CI] 1.01 to 1.05), total cholesterol (OR 1.35, 95% CI 1.11 to 1.65), plasminogen activator inhibitor-1 4G/4G (OR 1.72, 95% CI 1.20 to 2.45), and CRP levels Ͼ0.33 mg/L (OR 1.75, 95% CI 1.05 to 2.91) were all independently associated with a positive family history of myocardial infarction. We therefore conclude that raised levels of CRP independently identify the offspring of patients with a myocardial infarction. (Arterioscler Thromb Vasc

Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene

“…12,13 Perhaps our results might help understand the link between raised levels of CRP and a family history of myocardial infarction. 34 The exact mechanism by which the CRP polymorphism influences CRP gene expression is not yet known, but logical models can be entertained. The GT low alleles could of course be in linkage with an as yet unidentified element(s) in the proximal promoter region of the CRP gene, and we are currently investigating this possibility.…”

Inflammation, endothelial dysfunction, and the risk of high blood pressure: epidemiologic and biological evidence

“…A positive association between serum level of C-reactive protein (CRP) and blood pressure has been reported in several studies [12][13][14][15][16][17][18][19][20][21][22][23] (Table 1). This association is likely confounded by other risk factors, such as age, sex, and body mass index: Out of the six studies with no adjustment for potential confounders, [15][16][17][18][19]13 five [15][16][17][18][19] reported a statistically significant association between CRP and blood pressure (Table 1). Also, in a group of seven studies with adjustment for potential confounders, 12-24 four 24,22-24 reported a significant association between CRP and HBP.…”

“…Most of these studies [12][13][14][15][16][17][18][19][20][21][22] were not designed to test the CRP-HBP association. We tested this hypothesis in a random sample of free living subjects 23 and found a progressive increase in blood pressure associated to higher levels of high-sensitivity CRP.…”

Ebeveynleri erken koroner kalp hastalığı geçirmiş çocuklarda endotel işlevi ve trombotik sistem değerlendirmesi

“…These cytokines act locally or systemically. As a result of this complicated puzzle, the amount of TF in plasma increases via release from monocytes and neutrophils, circulatory platalets, endothelial cells or atherosclerotic plaque itself against the inflammatory response (28,29).…”

“…Increase in CRP is a marker of recurring ischemia, MI and sudden cardiac death in patients with CAD (29). Increase in highly sensitive CRP indicates increased inflammatory state in the vascular wall (28).…”