The oxidative stress responses caused by phthalate acid esters increases mRNA abundance of base excision repair (BER) genes in vivo and in vitro

Lu, Chihua; Luo, Juanjuan; Liu, Yao; Yang, Xiaojun

doi:10.1016/j.ecoenv.2020.111525

Cited by 26 publications

(26 citation statements)

References 42 publications

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“…An independent study reported the LC50 value of DEHP for zebrafish embryos from 72 to 168 hpf as 54.02 mg/L [ 41 ]. Regarding MEHP exposures, a significant increase in the mortality rate was observed in MEHP-exposed embryos in a dose- and time-dependent manner [ 42 ]. Table 1 summarizes the lethal effects from acute exposures to DEHP or MEHP on zebrafish embryos.…”

Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%

“…Kamstra et al reported reduction in body length [ 50 ], while Sant et al found abnormalities in the swim bladder in MEHP-exposed larvae [ 51 ]. On the other hand, Lu et al revealed decreases in the hatching rate, heart rate and body length as well as increased deformity in MEHP-exposed embryos when compared to the controls [ 42 ]. Table 2 summarizes developmental and morphological defects from acute exposures to DEHP or MEHP in zebrafish embryos.…”

Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%

“…The heart rate in zebrafish embryos has been widely used as an endpoint for assessing heart toxicity. Pu et al and Lu et al demonstrated that DEHP doses in the mg/L range could reduce the heart rate in embryos at 3 days post-fertilization (dpf) [ 37 , 42 ]. In contrast, the heart rate was significantly increased in embryos at a later development stage (168 hpf) upon treatment with lower DEHP doses (25 and 50 µg/L) [ 38 ].…”

Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%

“…In contrast, the heart rate was significantly increased in embryos at a later development stage (168 hpf) upon treatment with lower DEHP doses (25 and 50 µg/L) [ 38 ]. For MEHP exposure, Lu et al reported reduction of heart rate in embryos upon treatment with MEHP in the mg/L range [ 42 ]. Table 3 summarizes the cardiovascular toxicity from acute exposures to DEHP or MEHP on zebrafish embryos.…”

Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%

“…Exposures to DEHP have exerted behavioral toxicities on zebrafish embryos [ 37 , 42 , 46 , 53 ]. Spontaneous movement inhibition has been reported in zebrafish embryos upon DEHP exposures [ 37 , 53 ].…”

Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%

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Review on Toxic Effects of Di(2-ethylhexyl) Phthalate on Zebrafish Embryos

Kwan

Roy

2021

Toxics

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Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in consumer products. People are continuously exposed to DEHP through ingestion, inhalation and dermal absorption. From epidemiological studies, DEHP has been shown to associate with various adverse health effects, such as reproductive abnormalities and metabolic diseases. Health concerns have been raised regarding DEHP exposures; therefore, relevant risk assessment has become necessary through toxicological testing of DEHP. In the past 10 years, an increasing number of DEHP toxicity studies have been using zebrafish embryos as an in vivo model due to their high fecundity, rapid embryonic development as well as optical transparency, which have now been established as an alternative of the more conventional rodent model. The aim of the present paper is to review the effects of acute (from embryo stage to ≤1 week) and chronic (from embryo stage to >1 week) DEHP exposures on zebrafish, which start from the embryonic stage, and to analyze acute and potential long-term effects induced by acute exposure and effects induced by chronic exposure of DEHP upon subjecting to exposures, starting from the embryonic stage to different developmental stages, with a view to facilitate risk assessments on DEHP exposures.

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Section: Acute Effects Induced By Acute Exposurementioning

confidence: 99%