The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session – A Preliminary Study

Paprocki, J; Pawłowska, Marta; Sutkowy, Paweł; Piechocki, Jacek; Woźniak, Alina

doi:10.1515/phr-2017-0018

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…Because it is known that the imbalance of free radical formation or intensive consumption of antioxidant molecules leads to relatively decreased of biological macromolecules such as serum PON1 levels [9]. A balance shifting towards increased oxidative stress in SSNHL has been recently reported [2]. The most important finding of this study is, of course, the decrease in the PON1 concentrations in the serum of patients receiving HBOT.…”

Section: Discussionmentioning

confidence: 54%

“…The use of HBOT has increased markedly in various diseases over the past decade [1]. The etiology for sudden sensorineural hearing loss (SSNHL) is defined in only 10 % of cases, whereas the rest are labeled as idiopathic [2][3][4]. So, how can be HBOT effective with a common molecular pathway in treatment of SSNHL?…”

Section: Introductionmentioning

confidence: 99%

“…In particular, the feeding of the cochlea from the posterior cerebral circulation with a single terminal branch may explain the sudden and rapid course in the SSNHL of vascular etiopathogenesis. In addition, many clinical studies have shown that SSNHL patients often present with systemic arterial hypertension, diabetes mellitus and dyslipidemias with atherosclerosis, and thromboembolic risk [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Eren

Yılmaz

Yıldırım³

et al. 2020

Polish Hyperbaric Research

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Objective: Paraoxonase1 (PON1) and Arylesterase (ARE) levels are associated with reduced risk of atherosclerosis. The functional status of high density lipoprotein (HDL) is closely related to the PON1/ARE enzyme activity. Functional changes in treatment of sudden sensorineural hearing loss (SSNHL) may be achieved by post-translational modification of lipid metabolism induced by hyperbaric oxygen therapy (HBOT).Methods: Men patients with SSNHL who met the research criteria were included in the study. HBOT was performed on average 30 sessions. Laboratory measurements were made at the beginning and end of HBOT for the same patients. Serum levels of PON1/ARE and routine lipid laboratory parameters were measured to determine possible changes in SSNHL after HBOT.Results: In this study, a reducing effect on PON1 enzyme amount of long-term HBOT was detected. The serum PON1 amount of patients with SSNHL was 19.7 ± 2.7 ng / mL (mean ± SD) before HBOT, and the serum PON1 decreased to 17.0 ± 2.1 ng / mL (mean ± SD) after 30 sessions of HBOT. This decrease in PON1 levels was statistically significant (p =0.035). There was also a statistically significant decrease in the enzyme activity of ARE in the SSNHL patients (p=0.024).Conclusion: This preliminary study showed a significant decrease in serum PON1/ARE enzyme content in SSNLH patients with HBOT. In fact, it can be assumed that HBOT has no adverse effect on HDL functionality. However, the decrease in PON1 level by HBOT with 30 or more sessions may be important for the antioxidant function of HDL.It may possibly cause post-translational changes in antioxidant defense mechanisms due to increased oxidative stress with HBOT. In conclusion, larger clinical studies are needed to determine the possible effects of HBOT on HDL-related PON1/ARE functionality in SSNHL.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Eren

Yılmaz

Yıldırım³

et al. 2020

Polish Hyperbaric Research

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“…Paprocki et al [31], in a preliminary study in patients with SSNHL, demonstrated a reduction of the CAT activity approximately 5 minutes after the completion of a single HBO session. The largest reduction of the CAT activity was observed in patients under 35 years of age.…”

Section: Discussionmentioning

confidence: 99%

Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy

Paprocki

Sutkowy

Piechocki³

et al. 2019

Oxidative Medicine and Cellular Longevity

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The concentration of thiobarbituric acid reactive substances (TBARSs) in plasma and erythrocytes, the activity of selected antioxidant enzymes in erythrocytes: catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), and the levels of hemoglobin (HGB) and haematocrit (HCT) were determined in 40 patients with sudden sensorineural hearing loss (SSNHL) subjected to 14 treatment sessions in a Haux Starmed 2200 hyperbaric chamber. Hyperbaric oxygen (HBO) therapy involved breathing 100% oxygen at 0.25 MPa. Blood for analysis was collected from the basilic vein at three time points: before the first HBO session, approximately 5 min after the first session, and after the 14th session. The control group included 20 healthy individuals never before treated with HBO therapy. Compared to the pre-HBO values, a 10% increase (P<0.05) in the TBARS concentration in erythrocytes, a 28% increase in the GPx activity (P<0.05), and a 7% decrease in the SOD activity (P<0.05) were observed after 14 HBO sessions. The CAT activity decreased by 6% (P<0.05) after the first session. The TBARS concentration in plasma was 13% higher (P<0.01), while that in erythrocytes was 24% lower (P<0.001) in the SSNHL patients before the first HBO session compared to the control group. The CAT activity in the SSNHL patients before HBO therapy was 26% higher (P<0.001) than that in the control group. A statistically significant reduction in HGB and HCT after 14 HBO sessions (P<0.01) compared to the pre-HBO values was demonstrated. SSNHL is accompanied by disturbance in the oxidant-antioxidant equilibrium. Repeated stimulation with hyperbaric oxygen modulates the activity of antioxidant enzymes. It seems that the increased generation of hydrogen peroxide is responsible for the changes in the activity of antioxidant barrier enzymes observed after HBO sessions.

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“…A pressure of approximately 0.25 MPa is used for the purposes of the treatment [10]. This pressure allows oxygenation of all organs and tissues of the body including the middle ear to resolve hearing loss symptoms besides breathing 100% oxygen with a special mask [11].…”

Section: Introductionmentioning

confidence: 99%

İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi

Solak

Arslan

Kutlu

et al. 2018

Family Practice and Palliative Care

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Introduction: Idiopathic sudden sensorineural hearing loss (ISSNHL) is an otologic emergency that can lead to loss of function in one of the most important human senses. Recently, hyperbaric oxygen therapy (HBOT) has gained popularity with pharmacotherapy in ISSNHL. This study aimed to determine changes induced in thiol/disulfide homeostasis (TDH, a new biomarker of systemic oxidative stress) by pharmacotherapy and HBOT in patients with ISSNHL. Methods: This prospective study analyzed the albumin, total thiol, native thiol, and disulfide levels and disulfide-native thiol, disulfide-total thiol, and native thioltotal thiol ratios before and after HBOT with standardizing pharmacotherapy using a new colorimetric method in patients with ISSNHL. Results: 41 patients with ISSNHL including 14 (34.1%) women and 27 (65.9%) men participated in the study. The mean age of the patients was 48.02 ± 13.10 years. Of them, 24 (58.5%) had hearing loss in the right ear and 17 (41.5%) had hearing loss in the left ear. There was a statistically significant decrease in the albumin (p<0.001), total thiol (p<0.001), native thiol (p<0.001), and disulfide (p<0.001) levels after treatment compared to baseline. There was no statistically significant difference in the disulfide-native thiol (p=0.148), disulfide-total thiol (p=0.172), and native thiol-total thiol (p=0.169) ratios after treatment compared to baseline. Conclusion: Consequently, this study demonstrated that the thiol-disulphide balance tended to shift towards the oxidative side after HBOT and pharmacotherapy compared to baseline in patients with ISSNHL and that patients with high oxidation level after treatment had better treatment response.

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The Oxidant–Antioxidant Equilibrium in the Blood of People with Sudden Sensorineural Hearing Loss After the First Hyperbaric Oxygen Therapy Session – A Preliminary Study

Cited by 5 publications

References 19 publications

Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Markers of Oxidant-Antioxidant Equilibrium in Patients with Sudden Sensorineural Hearing Loss Treated with Hyperbaric Oxygen Therapy

İdiopatik ani işitme kaybı olan hastaların tiyol/disülfit homeostazisi üzerine hiperbarik oksijen tedavisinin etkisi

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