The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment

Baran, Maşallah; Appak, Yeliz Çağan; Karakoyun, Miray; Yalcinkaya, Sevda; Eliaçık, Kayı; Dündar, Bumin Nuri

doi:10.1097/meg.0000000000000979

Cited by 19 publications

(23 citation statements)

References 27 publications

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“…5 In another study by Baran and colleagues, significant improvement in the acid reflux index and symptoms of GERD was achieved after treatment of constipation. 6 We found no significant correlation between Rome III criteria and GERD. In the study by Baran and others, a significant relationship between GERD and constipation was found.…”

Section: Discussioncontrasting

confidence: 55%

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Clinical Manifestation of Gastroesophageal Reflux among Children with Chronic Constipation

Dehghani

Poorghaiomi

Javaherizadeh

2020

Middle East J Dig Dis

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BACKGROUND Functional gastrointestinal system diseases (FGIDs) are a group of childhood disorders, our knowledge of which is relatively limited. More importantly, the different subgroups among such a disease group are closely interrelated, and their natural courses and interrelations have yet to be fully clarified. Functional constipation and gastroesophageal reflux disease (GERD) are most frequently seen among this group. However, evidence as to whether any relationship exists between them is limited. In this study, we tried to examine the existence or absence of this relationship. METHODS First, patients with functional constipation were identified based on ROME III criteria, which included 205 patients. All patients were classified into two groups of 185 and 20 patients based on their ability to respond to the questions. Then age, sex, duration of constipation, treatment, and symptoms associated with reflux were examined based on the GERD questionnaire (in case group 185) and I-GERD (in case group 20). Score > 11 in the GERD questionnaire and score > 15 in the I-GERD questionnaire were considered as reflux disease. The variables that were evaluated using Chi-square and Fisher exact tests using SPSS software version 19 included age, sex, the onset of constipation, constipation duration, duration of treatment of constipation, ROME III criteria, and symptoms associated with reflux. RESULTS In the current study 205 subjects were included (girls = 49.8%, boys = 50.2%). The mean age of the children was 5.51 ± 3.15 years. Among the Rome III criteria, the most frequent were retentive posturing, painful defecation, history of large stool defecation, defecation less than 2 times per week, stool accumulation in the rectum, and fecal incontinency more than once a week, respectively. The lowest symptom among people with chronic constipation was fecal incontinency. Also, 46.8% of all patients in the study had a positive familial history. In general, there were 29 patients (14.1%) with reflux out of the 205 patients with functional constipation. In the present study, no significant relationship was found between Rome III criteria and reflux. CONCLUSION The frequency of GERD among cases with constipation was 14.1%. There was no significant relationship between Rome III criteria and reflux.

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Section: Discussioncontrasting

confidence: 55%

“…In another study by Baran and colleagues, significant improvement in the acid reflux index and symptoms of GERD was achieved after treatment of constipation. 6 …”

Section: Discussionmentioning

confidence: 99%

Clinical Manifestation of Gastroesophageal Reflux among Children with Chronic Constipation

Dehghani

Poorghaiomi

Javaherizadeh

2020

Middle East J Dig Dis

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“…It was seen that in children suffered from both GERD and FC, treatment of constipation led to a significant improvement in GERD symptoms. 43 Another study in Korean patients reported that the overlap of GERD or functional dyspepsia was common in patients with constipation. 44 …”

Section: Discussionmentioning

confidence: 99%

Prevalence of Chronic Constipation and Its Associated Factors in Pars Cohort Study: A Study of 9000 Adults in Southern Iran

Moezi¹,

Salehi²,

Molavi³

et al. 2018

Middle East J Dig Dis

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BACKGROUND Chronic constipation is one of the most common gastrointestinal disorders. It has negative effects on the patients’ quality of life, and their productivity, and results in a high economic burden on the healthcare services. The aim of the present study was to estimate the prevalence of chronic constipation and its associated factors in pars cohort study (PCS). METHODS A cross-sectional study was conducted on the baseline data of the PCS. Data gathering was done by structured questionnaire and physical examination. A total of 9264 subjects aged between 40 and 75 years were enrolled in the PCS. Diagnosis of chronic constipation was done using Rome IV criteria. Multivariable binary logistic regression was applied for data analysis. RESULTS A total of 752 (8.1%) participants were diagnosed as having chronic constipation (9.3% of female and 6.7% of male participants). Older age (OR: 1.55, 95% CI: 1.31-1.83), physical activity (OR: 0.56, 95% CI: 0.46-0.68), opium consumption (OR: 2.06, 95% CI: 1.63-2.60) , anxiety (OR: 1.38, 95% CI: 1.15-1.65), depression (OR: 1.22, 95% CI: 1.01-1.48), back pain or arthralgia (OR: 1.38, 95% CI: 1.14-1.67), insomnia (OR: 1.62, 95% CI: 1.36-1.93) and gastroesophageal reflux disease (OR: 1.51, 95% CI: 1.28-1.78) were associated with the prevalence of constipation in the multivariable analysis. CONCLUSION Chronic constipation was a common problem in the PCS population. Decreasing modifiable risk factors associated with constipation such as opium consumption and physical inactivity can reduce its prevalence and decrease burden of the disease.

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“…Treatment of constipation has been associated with improved reflux symptom in children. 37 Many of our patients already had a history of constipation or they developed it during the IFP. We observed that initiation of a stool softener led to improvement in their feeding progress.…”

Section: Discussionmentioning

confidence: 92%

Gastrointestinal Conditions in Children With Severe Feeding Difficulties

Rivera-Nieves

Conley

Nagib

et al. 2019

Global Pediatric Health

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Feeding aversion in children may progress to severe feeding difficulties. While oral-motor and sensory issues are usually the leading causes, organic etiologies should be considered. This study aimed to assess the prevalence of gastrointestinal conditions in children with severe feeding difficulties. We conducted a retrospective study of 93 children requiring an intensive feeding program. The medical records, radiologic and diagnostic tests, use of gastric tube feedings, preexisting medical conditions, and medications were reviewed. Fifty-two percent (52%) had esophagitis, 26.2% gastritis, and 40.7% lactase deficiency in upper endoscopy. In those who underwent an upper endoscopy, 26% of patients that were also tested for small intestinal bacterial overgrowth were found to be positive. Allergy testing was abnormal in 56.6% of those tested, while 27.5% and 75% had abnormal gastric emptying times and pH impedance results, respectively. Constipation was present in 76.3%. Thirteen of 32 were weaned off tube feedings. We conclude that gastrointestinal conditions are common in children with feeding disorders and should be investigated prior to feeding therapy.

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The overlap of gastroesophageal reflux disease and functional constipation in children: the efficacy of constipation treatment

Abstract: GERD is a frequent problem in children with FC. Treatment of the constipation can improve the reflux symptoms and abnormal acid reflux in these cases. Physicians should bear in mind the co-occurrence of these two prevalent problems for better disease management.

Cited by 19 publications

References 27 publications

Clinical Manifestation of Gastroesophageal Reflux among Children with Chronic Constipation

Clinical Manifestation of Gastroesophageal Reflux among Children with Chronic Constipation

Prevalence of Chronic Constipation and Its Associated Factors in Pars Cohort Study: A Study of 9000 Adults in Southern Iran

Gastrointestinal Conditions in Children With Severe Feeding Difficulties

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