The Ovarian Tumor Index predicts risk for malignancy

Twickler, Diane M.; Forte, Thalia B.; Santos‐Ramos, Rigoberto; McIntire, Donald; Harris, Patsy; Miller, David S.

doi:10.1002/(sici)1097-0142(19991201)86:11<2280::aid-cncr16>3.0.co;2-h

Cited by 35 publications

(11 citation statements)

References 17 publications

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“…The combined use of morphologic scoring and Doppler US may help overcome problems of color and duplex Doppler imaging and improve the assessment of adnexal masses [19,20]. Twickler et al have shown that the ovarian tumor index, which combines the patient's age with specific ultrasonographic markers, is an accurate method for predicting ovarian malignancy in cases with suspected adnexal masses [20].…”

Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

“…Twickler et al have shown that the ovarian tumor index, which combines the patient's age with specific ultrasonographic markers, is an accurate method for predicting ovarian malignancy in cases with suspected adnexal masses [20]. The morphological characteristics were evaluated employing the Sassone morphologic scale shows a low signal intensity on a T1-weighted image and a high signal intensity on a T2-weighted image.…”

Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

“…It completely lacks enhancement on the d contrast-enhanced image, indicating that these are clots adhered to the wall [13]. An ovarian tumor index of higher than 90 has a 78% probability of malignancy (sensitivity of 11%, specificity of 99%, PPV 75%, NPV 89%), compared with an ovarian tumor index higher than 45 that has an estimated 12% probability of malignancy (sensitivity 85%, specificity 83%, PPV 41%, NPV, 98%) [20]. This probability assignment may be an alternative to absolute cut-off index.…”

Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

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Ovarian cancer: the clinical role of US, CT, and MRI

Togashi

2003

Eur Radiol

116

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This article presents an overview of ovarian cancer, which addresses the clinical roles of imaging studies, including US, CT, and MR imaging in the course of diagnosis and treatment of this important disease. US is the modality of choice in the evaluation of patients with suspected adnexal masses. Although its accuracy is not sufficient to avert surgery, morphological analysis of adnexal masses with US helps narrow the differential diagnosis, determining the degree of suspicion for malignancy, usually in concert with a serum CA-125 level. Combined morphological and vascular imaging obtained by US appear to further improve the preoperative assessment of adnexal masses. For uncertain or problematic cases, MR imaging helps to distinguish benign from malignant, with an overall accuracy for the diagnosis of malignancy of 93%. The accuracy of MR imaging in the confident diagnosis of mature cystic teratoma, endometrial cysts, and leiomayomas is very high. CT is not indicated for differential diagnosis of adnexal masses because of poor soft tissue discrimination, except for fatty tissue and for calcification, and the disadvantages of irradiation. In the staging of ovarian cancer, CT, US, and MR imaging all have a similarly high accuracy. Although it is difficult to suggest a simple algorithm for evaluating the state of women with adnexal masses, the correct preoperative diagnosis and staging of ovarian cancer with the use of any of these imaging studies will lead to an appropriate referral to a specialist in gynecologic oncology and offer a significant survival advantage for patients with ovarian cancer.

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Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

Section: Analysis Of Ovarian Masses: Benign Vs Malignantmentioning

confidence: 99%

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Ovarian cancer: the clinical role of US, CT, and MRI

Togashi

2003

Eur Radiol

116

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“…Our study focused on simple cysts with no papillary projections, a clearly defined smooth cyst wall, and a clear cyst content; endometriotic cysts had diffuse low-level echoes within, but the other characteristics of simple cysts usually applied. Thus, we thought the chance of malignancy was relatively low in all cases, even when ovarian volume, morphology, and Doppler indexes were considered in addition to patient age (37,38). Cytologic examination of the cyst content is not considered reliable in excluding malignancy, however, mainly because of the inadequate number of cells in the specimen (3).…”

Section: Discussionmentioning

confidence: 99%

Management of Ovarian Cysts with Aspiration and Methotrexate Injection

Mesogitis¹,

Pilalis²,

Papantoniou³

et al. 2005

Radiology

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“…Afin d'améliorer ces performances des index de risque de malignité ont été proposés [28][29][30][31][32][33][34][35][36]. Le calcul de ces index associe dans des algorithmes l'état ménopausique, les caractéristiques échographiques et la valeur du CA 125.…”

Section: Ca 125 En Situation Diagnostiqueunclassified