Objective To assess the role of maternal demographic characteristics, uterine artery Doppler velocimetry, maternal serum pregnancy-associated plasma protein-A (PAPP-A (OR, 2.0; 95% CI, and low 0.43; 95% CI,. Increased uterine artery PI was the only independent factor in the prediction of placental abruption (OR, 8.49; 95% CI,

No abstract

Objective To assess the feasibility of examining cardiac and non-cardiac fetal anatomy in a low-risk population in the setting of the routine 11-14-week ultrasound scan. Methods

A late third trimester ultrasound was superior in the prediction of SGA and LGA, and this improvement was more pronounced for the prediction of SGA.

Prediction for birthweight deviations is feasible using data available at the routine 11-14 weeks' examination. Delta CRL and delta nuchal translucency were significant independent predictors for both SGA and LGA.

Objectives

Obliteration of the CM appears to be the most consistent early sign of open neural tube defects. Attention should focus on either measuring the cisterna magna or simply observing the presence of four lines in the midsagittal view of the posterior brain. However, these early signs of brain herniation are not present in all abnormal cases.

Objective To measure the intracranial translucency (IT) and the cisterna magna (CM), to produce reference ranges and to examine the interobserver and intraobserver variability of those measurements. To examine the possible association of IT with chromosomal abnormalities.Methods Prospective study on pregnancies assessed at 11 to 14 weeks. IT was measured retrospectively in 17 cases with aneuploidy.Results To produce reference ranges, 465 fetuses were used. IT and CM correlated linearly with crown-rump-length (CRL) and were independent of maternal demographic characteristics and biochemical indices. IT had a weak positive correlation with nuchal translucency. For IT the intraclass correlation coefficient was 0.88 for intraobserver variability and 0.83 for interobserver variability. For CM the intraclass correlation coefficient was 0.95 for intraobserver variability and 0.84 for interobserver variability. The IT multiple of the median was significantly increased in the chromosomally abnormal fetuses (1.02 for the normal and 1.28 for the chromosomally abnormal fetuses, Mann Whitney p < 0.001). IT multiple of the median was a significant predictor of chromosomal abnormality (Receiver Operator Characteristic curve analysis: Area under the curve = 0.86, CI=0.76-0.96, p<0.001).Conclusion Intracranial translucency and CM can be measured reliably at the 11 to 14 weeks examination and the measurements are highly reproducible. IT appears to be increased in fetuses with chromosomal abnormalities.