The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors

Simani, Leila; Ramezani, Mahtab; Roozbeh, Mehrdad; Shadnia, Shahin; Pakdaman, Hossein

doi:10.1080/01480545.2020.1845192

Cited by 18 publications

(39 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another major concern, in the absence of licit alcohol, has been the consumption of methanol or of household products leading to methanol toxicity, as reported from Iran [ 14 ▪▪ ]. Serious complications, including blindness, putamen necrosis, subcortical white matter haemorrhage and even death have been reported.…”

Section: Text Reviewmentioning

confidence: 99%

Effects of the COVID-19 pandemic and lockdown on alcohol use disorders and complications

Murthy

Narasimha

2021

Current Opinion in Psychiatry

100

View full text Add to dashboard Cite

Purpose of review To understand the effect of COVID-19 pandemic and lockdown on persons with alcohol use disorders. Recent findings From a total of 455 titles on COVID-19 and alcohol, 227 abstracts were screened, and 95 articles were reviewed (on November 25 th , 2020). The immediate effect was an increase in alcohol related emergencies including alcohol withdrawal, related suicides, and methanol toxicity. Although there are mixed findings with respect to changes in the quantity of drinking, there are reports of binge/heavy drinking during the lockdown as well as relapse postlockdown. Psychological, social, biological, economic and policy-related factors appear to influence the changes in drinking. Although preliminary data suggest no change in alcohol use among persons with comorbid mental illness, findings in this population are presently limited. Among patients with alcohol related liver disease, outcomes appear worse and caution is warranted with the use of medications. Alcohol also appears to increases the risk of COVID-19 infection and complicates its course. Although some nations banned alcohol sales completely during lockdown, others declared it as an essential commodity, resulting in different problems across countries. Alcohol use has added to the burden of the problem particularly among vulnerable groups like the adolescents, elderly, patients with cancer, as well as health professionals. Services for patients with alcohol use disorders have been affected. Summary The COVID-19 pandemic has had considerable impact on alcohol use, with an increase in alcohol related emergencies, changes in alcohol use patterns, increased risk of contracting COVID-19, effect on alcohol policies and sales, and an effect on vulnerable groups. It is essential to understand and respond to the current situation, intervene early, and prevent further repercussions of the pandemic. Video abstract link: https://drive.google.com/file/d/1IJWtIs6e554PryKWhdma4VB--mjSZq1C/view?usp=sharing .

show abstract

Section: Text Reviewmentioning

confidence: 99%

Effects of the COVID-19 pandemic and lockdown on alcohol use disorders and complications

Murthy

Narasimha

2021

Current Opinion in Psychiatry

100

View full text Add to dashboard Cite

show abstract

“…Darüber hinaus häufen sich Berichte über Personen, die Methanol im Glauben an einen antiviralen Effekt bzw. aufgrund von Coronaphobie eingenommen haben [4,5]. Wir diskutieren das klinische Spektrum, die erforderliche Diagnostik und die bestmögliche klinische Versorgung dieser Kollateralschäden durch COVID 19.…”

Section: » Erste Vergiftungserscheinungen Können Bereits Nach Einer Stunde Auftretenunclassified

“…Die Methanolvergiftung kann inzwischen als Kollateralschaden der COVID-19-Pandemie angesehenwerden, wie eine Reihe von Berichten in der wissenschaftlichen Literatur aufzeigen [4][5][6]. Die Methanolkontamination von Händedesinfektionsmitteln scheint eine COVID-19bedingte Entwicklung zu sein, nachdem der Bedarf im Zuge der Pandemie exponentiell gestiegen ist und Qualitätssicherungsmaßnahmen unzureichend gewesen sein dürften.…”

Section: Diskussionunclassified

“…Als weitere Gefahr ist der Irrglaube einer protektiven Wirkung von Ethanol auf eine Infektion mit dem SARS-CoV-2 zu sehen. Vor allem in Ländern mit Konsumationsverbot von alkoholhaltigen Getränken dürfte die Menge an selbst gebranntem Alkohol und in der Folge die Kontamination mit Methanol gestiegen sein [4]. Dies lässt sich auch an den berichteten Zahlen aus dem Iran bestätigen, wo laut Associated Press zum 20.…”

Section: Diskussionunclassified

“…Intrakranielle Hämorrhagien (Prädilektion in den Basalganglien) und Nekrosen in verschiedenen Hirnregionen (Putamen, pontines Tegmentum und Zerebellum) zählen zu weiteren Komplikationen. Es können sich hiervon auch parkinsonoide Symptomatiken (Rigor, Tremor, Hypomimie und Hypophonie) entwickeln [1][2][3][4][5].…”

Section: Introductionunclassified

See 2 more Smart Citations

Methanolintoxikation: ein Kollateralschaden der COVID-19-Pandemie

Wuchty

Perneczky

Sellner

2021

psychopraxis. neuropraxis

View full text Add to dashboard Cite

Das vermehrte Auftreten von Methanolvergiftungen während der COVID-19-Pandemie durch mit Methanol verunreinigte Desinfektionsmittel wird durch mehrere Berichte in der Literatur belegt. Zum einen kann der Konsum von mit Methanol verunreinigten Desinfektionsmitteln oder alkoholischen Getränken zur akuten Intoxikation führen. Zum anderen wurde eine chronische Intoxikation durch Inhalation nach Reinigung der Gesichtsmaske mit einem mit Methanol versetzten Mittel berichtet. Bei unklaren neurologischen Ausfällen mit Nachweis einer metabolischen Azidose mit Anionenlücke muss an die Methanolintoxikation gedacht werden. Essenziell ist ein schneller Therapiebeginn bereits im Verdachtsfall, um das Auftreten toxischer Metabolite zu unterbinden. Die Therapieoptionen umfassen 4‑Methylpyrazol, Ethanol, Magenspülung, Folsäure und Natriumbikarbonat. In schweren Fällen wird eine Hämodialyse durchgeführt.

show abstract

Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes

Esmaeilian,

Teimouri,

Hooshmandi

et al. 2023

Health Science Reports

View full text Add to dashboard Cite

ObjectiveTo evaluate the frequency and significance of brain imaging findings in methanol poisoning patients and to propose a criterion for prioritizing brain imaging.MethodsWe retrospectively reviewed the data of 306 patients (286 men and 34 women, mean age 32.10 ± 9.9 years) with confirmed methanol poisoning who were admitted to two hospitals in Iran during the COVID‐19 pandemic. We analyzed their demographic, clinical, laboratory, and brain imaging data.ResultsThe main brain computed tomography (CT) scan findings were hypodensity in the putamen (11.1%), cerebellar nuclei (8.2%), diffuse cerebral edema (7.5%), and intracranial hemorrhage (ICH; 1.6%). These findings were associated with blood pH, Glasgow Coma Scale (GCS), renal failure, bicarbonate, oxygen, carbon dioxide, potassium, and glucose levels (p < 0.05). Poor prognosis was related to blindness, opium addiction, chronic alcohol use, hyperglycemia, and abnormal CT scans (p < 0.001 for all). The most predictive brain imaging findings for poor prognosis were hypodensity in the cerebellar nuclei, diffuse cerebral edema, and ICH.ConclusionBrain imaging can provide valuable information for the diagnosis and management of methanol poisoning patients. We suggest that patients with severe acidosis, low GCS, low pH, low oxygen saturation, and high glucose levels should undergo brain CT scan as a priority.

show abstract

The outbreak of methanol intoxication during COVID-19 pandemic: prevalence of brain lesions and its predisposing factors

Cited by 18 publications

References 20 publications

Effects of the COVID-19 pandemic and lockdown on alcohol use disorders and complications

Effects of the COVID-19 pandemic and lockdown on alcohol use disorders and complications

Methanolintoxikation: ein Kollateralschaden der COVID-19-Pandemie

Methanol poisoning during the COVID‐19 pandemic in Iran: A retrospective cross‐sectional study of clinical, laboratory, and brain imaging characteristics and outcomes

Contact Info

Product

Resources

About